19F MR imaging

Easily Available, Low Cost 19F-MRI Agents: Poly(ethylene-glycol)-functionalized Fluorinated Ethers.
C. Biaggi, M. Benaglia, M. Ortenzi, E. Micotti, C. Perego,M. G. De Simoni Journal of Fluorine Chemistry, 2013, 153,172-177 [Link]
Abstract: Poly(ethylene-glycol) derivatives of different fluorine content were easily synthesized. In all cases a single 19F signal at NMR in deuterated chloroform and D2O was registered; in a few cases a good solubility in water was observed and a clear imaging was obtained in experiments of in vitro MR imaging. In one case a novel fluorinated polymer was tolerated in low doses when in vivo experiments on animals (mice) were conducted.



Poly(ethylene-glycol)-based Fluorinated Esters: a Readily Available Entry for Novel 19F-MRI agents
S. Rossi, M. Benaglia, M. Ortenzi, E. Micotti, C. Perego, M. G. De Simoni, Tetrahedron Lett., 2011, 52, 6581-6583. [Link]
Abstract: Readily available, low cost, hydrosoluble poly(ethylene-glycol) derivatives of 2-(trifluoromethyl)-3,3,3-trifluoro-propanoic acid were easily synthesized and their properties as MRI agents are preliminarily investigated. Two novel polymers, of 2356 Da and 756 Da, respectively, both showing a single 19F signal at NMR in deuterated chloroform and D2O were fully characterized; both compounds were shown to be soluble in water. However when experiments of in vitro MR imaging were conducted a clear imaging was obtained only with the sample of 756 MW, pointing at the importance of the fluorine content of the carrier..



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