APIS group Blog

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beta-Hairpin mimics containing a piperidine– pyrrolidine scaffold modulate the beta-amyloid aggregation process preserving the monomer species

Chem. Sci., 2017, 8, 1295–1302 DOI: 10.1039/C6SC03176E Alzheimer’s disease is a neurodegenerative disorder linked to oligomerization and fibrillization of amyloid b peptides, with Ab1–42 being the most aggregative and neurotoxic one. We report herein...

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Aqueous self-assembly of short hydrophobic peptides containing norbornene amino acid into supramolecular structures with spherical shape

RSC Adv., 2016,6, 90754-90759 DOI: 10.1039/C6RA17116H formation of supramolecular assembly is reported. The two diastereoisomeric pentapeptides AcAla- NRB-Ala-Aib-AlaNH2 1 and 2 containing the two enantiomers of non-proteinogenic norbornene amino acid (NRB) were synthesized in...

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Ctr-1 Mets7 motif inspiring new peptide ligands for Cu(I)-catalyzed asymmetric Henry reactions under green conditions

RSC Adv., 2016,6, 71529-71533 DOI: 10.1039/C6RA16255J Taking inspiration from the Ctr-1 Mets7 Cu(I) binding motif, effective hybrid catalysts have been developed for asymmetric Henry condensations under green conditions. The introduction of an unnatural dipeptide...

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Structural insight into the interaction of O‐acetylserine sulfhydrylase with competitive, peptidic inhibitors by saturation transfer difference‐NMR

  FEBS Letters 590 (2016) 943–953 ª 2016 Federation of European Biochemical Societies doi:10.1002/1873-3468.12126 O-acetylserine sulfhydrylase (OASS), the enzyme catalysing the last step of cysteine biosynthesis in bacteria, is involved in antibiotic resistance and...

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MoGlyNet

The Horizon 2020 MSCA joint doctoral project MoGlyNet (“Modulation of glycolytic flux as a new approach for treatment of atherosclerosis and plaque stabilization: a multidisciplinary study”) is run by a Consortium of Universities in...

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Dipeptide Nanotubes Containing Unnatural Fluorine-Substituted β2,3-Diarylamino Acid and L‑Alanine as Candidates for Biomedical Applications

 The synthesis and the structural characterization of dipeptides composed of unnatural fluorine-substituted β2,3-diarylamino acid and L-alanine are reported. Depending on the stereochemistry of the β amino acid, these dipeptides are able to self-assemble into proteolytic stable nanotubes....