|
REFERENCES:
Alcazar J, Diels G, Schoentjes, B. Applications of the
combination of microwave and parallel synthesis in medicinal chemistry. Combi.
Chem & HTS 2007;10(10):918-32.
Bertrand
MJM, Milutinovic S, Dickson KM, et al. cIAP1 and cIAP2 facilitate cancer cell
survival by functioning as E3 ligases that promote RIP1 ubiquitination.
Molecular Cell 2008;30(6):689-700.
Boldin
MP, Goncharov TM, Goltseve YV, Wallach D. Involvement of MACH, a novel
MORT1/FADD-interacting protease, in Fas/APO-1- and TNF Receptor–Induced cell
death. Cell 1996;85(6):803-15.
Cassinelli
G, Supino R, Perego P, Polizzi D, Lanzi C, Pratesi G, Zunino F. A role for loss
of p53 function in sensitivity of ovarian carcinoma cells to taxanes. Int J
Cancer. 2001; 92:738-47.
Cheung
HH, Plenchette S, Kern CJ, Mahoney DJ, Korneluk RG. The RING domain of cIAP1
mediates the degradation of RING-bearing inhibitor of apoptosis proteins by
distinct pathways. Mol Biol Cell 2008;19(7):2729-40.
Cossu F,
Mastrangelo E, Milani M, et al. Designing smac-mimetics as
antagonists of XIAP, cIAP1, and cIAP2. Biochemical and Biophysical Research
Communications 2009;378(2):162-7.
Cossu
F, Milani M, Mastrangelo E, et al. Structural basis
for bivalent smac-mimetics recognition in the IAP protein family. J Mol Biol 2009; in press.
Daniotti
M, Oggionni M, Ranzani T, et al. BRAF alterations are associated with complex
mutational profiles in malignant melanoma. Oncogene 2004;23(35):5968-77.
Datta R,
Oki E, Endo K, Biedermann V, Ren J, Kufe D. XIAP regulates DNA damage-induced
apoptosis downstream of caspase-9 cleavage. J Biol Chem
2000;275(41):31733-8.
De Cesare
M, Perego P, Righetti SC, et al. Enhanced antitumour efficacy of
gimatecan in combination with bcl-2 antisense oligonucleotide in human melanoma
xenografts. European Journal of Cancer 2005;41(8):1213-22.
Deveraux
QL, Takahashi R, Salvesen GS, Reed JC. X-linked IAP is a direct inhibitor of
cell-death proteases. Nature 1997;388(6639):300-4.
Du C,
Fang M, Li Y, Li L, Wang X. Smac, a mitochondrial protein that promotes
cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell.
2000 Jul 7;102(1):33-42.
Dubrez-Daloz L, Dupoux A, Cartier J. IAPs: More than
just inhibitors of apoptosis proteins. Cell Cycle 2008;7(8):1036-46.
Evan GI,
Vousden KH. Proliferation, cell cycle and apoptosis in cancer. Nature. 2001
411(6835):342-8.
Fong WG,
Liston P, Rajcan-Separovic E, St Jean M, Craig C, Korneluk RG. Expression and
genetic analysis of XIAP-associated factor 1 (XAF1) in cancer cell lines.
Genomics. 2000; 70(1):113-22.
Gaither
A, Porter D, Yao Y, et al. A smac mimetic rescue screen reveals roles for
inhibitor of apoptosis proteins in tumor necrosis factor-{alpha}
signaling. Cancer Res 2007;67(24):11493-8.
Galbán
S, Hwang C, Rumble JM, Oetjen KA, Wright CW, Boudreault A, Durkin J, Gillard
JW, Jaquith JB, Morris SJ, Duckett CS. Cytoprotective effects of IAPs revealed by a small molecule antagonist. Biochem
J. 2009; 417(3):765-71.
Hunter AM, LaCasse EC, Korneluk RG. The inhibitors of apoptosis (IAPs) as
cancer targets. Apoptosis. 2007;12(9):1543-68.
Jiang CC, Chen LH, Gillespie S, et al. Tunicamycin
sensitizes human melanoma cells to tumor necrosis factor-related
apoptosis-inducing ligand-induced apoptosis by up-regulation of TRAIL-R2 via
the unfolded protein response. Cancer Res 2007;67(12):5880-8.
Johnstone
RW, Ruefli AA, Lowe SW. Apoptosis: a link between cancer genetics and
chemotherapy. Cell. 2002; 108(2):153-64.
Leslie
BJ, Hergenrother PJ. Identification of the cellular targets of bioactive small
organic molecules using affinity reagents. Chem. Soc. Rev. 2008;37(7):1347-60.
Li L,
Thomas RM, Suzuki H, De Brabander JK, Wang X, Harran PG. A small molecule smac
mimic potentiates TRAIL- and TNF{alpha}-mediated
cell death. Science 2004;305(5689):1471-4.
Lu J, Bai L, Sun H, et al. SM-164: A novel, bivalent smac
mimetic that induces apoptosis and tumor regression by concurrent removal of
the blockade of cIAP-1/2 and XIAP. Cancer Res
2008;68(22):9384-93.
Manzoni L, Arosio D, Belvisi L,
Bracci A, Colombo M, Invernizzi D, Scolastico C. Functionalized azabicycloalkane amino acids by nitrone 1,3-dipolar
intramolecular cycloaddition. J. Org. Chem.
2005;70(10):4124-32.
Mastrangelo
E, Cossu F, Milani M, et al. Targeting the X-linked inhibitor
of apoptosis protein through 4-substituted azabicyclo[5.3.0]alkane smac
mimetics. structure, activity, and recognition principles. Journal of Molecular
Biology 2008;384(3):673-89.
Nikolovska-Coleska
Z, Wang R, Fang X, et al. Development and optimization of
a binding assay for the XIAP BIR3 domain using fluorescence polarization.
Analytical Biochemistry 2004;332(2):261-73.
Nikolovska-Coleska
Z, Meagher JL, Jiang S, et al. Design and characterization of
bivalent smac-based peptides as antagonists of XIAP and development and
validation of a fluorescence polarization assay for XIAP containing both BIR2
and BIR3 domains. Analytical Biochemistry
2008;374(1):87-98.
Petersen
SL, Wang L, Yalcin-Chin A, et al. Autocrine TNFα signaling
renders human cancer cells susceptible to smac-mimetic-induced apoptosis.
Cancer Cell 2007;12(5):445-56.
Reed JC.
Drug insight: cancer therapy strategies based on restoration of endogenous cell
death mechanisms. Nat Clin Pract Oncol. 2006; 3(7):388-98.
Srivanasula
SM, Ashwell JD. IAPs: What’s in a name? Molecular
Cell 2008;30:123-32.
Sun
H, Nikolovska-Coleska Z, Yang C, et al. Structure-based
design, synthesis, and evaluation of conformationally constrained mimetics of
the second mitochondria-derived activator of caspase that target the X-linked
inhibitor of apoptosis Protein/Caspase-9 interaction site. J Med Chem 2004;47(17):4147-50.
Sun
H, Nikolovska-Coleska Z, Yang C, et al. Structure-based
design of potent, conformationally constrained smac mimetics. J Am Chem Soc
2004;126(51):16686-7. (b)
Sun H,
Nikolovska-Coleska Z, Lu J, Qiu S, Yang C-Y, Gao W, Meagher J, Stuckey J, Wang
S. Design, synthesis and evaluation of a potent, cell-permeable,
conformationally constrained Second Mitochondria Derived Activator of Caspase
(Smac) mimetic. J. Med. Chem. 2006;49(26):7916-20.
Vaculova A, Zhivotovsky B. Caspases: Determination of their activities in
apoptotic cells. Methods Enzymol. 2008;442:157-81.
Varfolomeev
E, Blankenship JW, Wayson SM, et al. IAP antagonists induce autoubiquitination
of c-IAPs, NF-κB activation, and TNFα-dependent apoptosis. Cell
2007;131(4):669-81.
Vaux DL,
Silke J. IAPs, RINGs and ubiquitylation. Nature Rev. Mol. Cell. Biol.
2005;6:287-97.
Vince
JE, Wong WW, Khan N, et al. IAP antagonists target cIAP1 to induce
TNFα-dependent apoptosis. Cell 2007;131(4):682-93.
Wang L,
Du F, Wang X. TNF-α induces two distinct caspase-8 activation pathways. Cell
2008;133(4):693-703.
Wilkinson
JC, Wilkinson AS, Galban S, Csomos RA, Duckett CS. Apoptosis-inducing factor is
a target for ubiquitination through interaction with XIAP. Mol Cell Biol
2008;28(1):237-47.
Wu G,
Chai J, Suber TL, Wu JW, Du C, Wang X, Shi Y. Structural basis of IAP
recognition by Smac/DIABLO. Nature. 2000; 408(6815):1008-12.
Wu H,
Tschopp J, Lin SC. Smac mimetics and TNFalpha: a dangerous liaison? Cell. 2007;
131(4):655-8.
Yang Y,
Fang S, Jensen JP, Weissman AM, Ashwell JD. Ubiquitin protein ligase activity
of IAPs and their degradation in proteasomes in response to apoptotic stimuli.
Science. 2000; 288(5467):874-7.
Zhang
XD, Franco AV, Nguyen T, Gray CP, Hersey P. Differential localization and
regulation of death and decoy receptors for TNF-related apoptosis-inducing
ligand (TRAIL) in human melanoma cells. J Immunol 2000;164(8):3961-70.
Zhang
XD, Zhang XY, Gray CP, Nguyen T, Hersey P. Tumor necrosis factor-related
apoptosis-inducing ligand-induced apoptosis of human melanoma is regulated by
Smac/DIABLO release from mitochondria. Cancer Res 2001;61(19):7339-48.
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