Work Experience and Education



09/2013 - 08/2015 Postdoctoral fellow

                              Structural Biology Lab, Department of Biosciences, University of Milano, Italy.


07/2009 - 08/2013 Postdoctoral fellow

                              Protein-Nucleic Acids Interactions group, Instituto Gulbenkian da Cienca (IGC), Oeiras, Portugal


02/2008 - 06/2009 Postdoctoral fellow

                              Macromolecular Crystallography Unit, ITQB, Universidade Nova de Lisboa, Oeiras, Portugal


06/2004 - 12/2007 PhD Student in Molecular Biology

                               Enzymology Lab, Department of Biomolecular Sciences and Biotechnology, University of Milan, Italy


05/2004 Master (pre-Bologna, five-year degree) in Biological Sciences

              Final grade: 110/110 cum laude; Majors:  Molecular Biology, Biochemistry, Enzymology



Grants and Fellowships



2017 Research Grant awarded by Amyloidosis Foundation as main proponent


2015 Telethon exploratory grant awarded by Fondazione Telethon (GEP15070) as main proponent


2010-2013 Postdoctoral fellowship awarded by FCT (Portuguese federation for Science and technology)


2009 Research grant in memory of Professor Bruno Curti awarded by SIB (Italian society of   Biochemistry)


2008 FEBS short-term fellowship (by Federation of European Biochemical Societies)




Selected Publications


Bonì F, Milani M, Barbiroli A, Diomede L, Mastrangelo E, de Rosa M. Gelsolin pathogenic Gly167Arg mutation promotes domain-swap dimerization of the protein. Hum Mol Genet. 2017 Oct 23. doi: 10.1093/hmg/ddx383. [Epub ahead of print] PMID: 29069428


Boni F., Milani M., Porcari R., Barbiroli A., Ricagno S. and de Rosa M. Molecular basis of a novel renal amyloidosis due to N184K gelsolin variant.  Sci Rep. 2016 Sep 16;6:33463. doi: 10.1038/srep33463.


de Rosa M, Barbiroli A, Giorgetti S, Mangione PP, Bolognesi M, Ricagno S. Decoding the Structural Bases of D76N b2-Microglobulin High Amyloidogenicity through Crystallography and Asn-Scan Mutagenesis. PLoS One. 2015;10(12):e0144061.


de Rosa M, Zacarias S, Athanasiadis A. Structural basis for Z-DNA binding and stabilization by the zebrafish Z-DNA dependent protein kinase PKZ. Nucleic Acids Res. 2013;41(21):9924-33.


de Rosa M, de Sanctis D, Rosario AL, Archer M, Rich A, Athanasiadis A, Carrondo MA. Crystal structure of a junction between two Z-DNA helices. Proc Natl Acad Sci U S A. 2010;107(20):9088-92




Matteo De Rosa, PhD


CNR Researcher


Researchgate, Orcid, IBF-CNR


Last update 01/12/20

The Structural Biology Group comprises members from both the DBS-UNIMI and the IBF-CNR. The content herein is not regulated by the University of Milan.