2017

 

Functionalized 2,1-benzothiazine 2,2-dioxides as new inhibitors of Dengue NS5 RNA-dependent RNA polymerase. Cannalire R, Tarantino D, Astolfi A, Barreca ML, Sabatini S, Massari S, Tabarrini O, Milani M, Querat G, Mastrangelo E, Manfroni G, Cecchetti V. Eur J Med Chem. 2017 Nov 11. pii: S0223-5234(17)30866-8.

 

Concurrent structural and biophysical traits link with immunoglobulin light chains amyloid propensity. Oberti L, Rognoni P, Barbiroli A, Lavatelli F, Russo R, Maritan M, Palladini G, Bolognesi M, Merlini G, Ricagno S. Sci Rep. 2017 Dec 1;7(1):16809.

 

Identification of a small molecule that compromises the structural integrity of viroplasms and rotavirus double-layered particles. Eichwald C, De Lorenzo G, Schraner EM, Papa G, Bollati M, Swuec P, de Rosa M, Milani M, Mastrangelo E, Ackermann M, Burrone OR, Arnoldi F. J Virol. 2017 Nov 15. pii: JVI.01943-17.

 

Stabilization and structural analysis of a membrane-associated hIAPP aggregation intermediate. Rodriguez Camargo DC, Korshavn KJ, Jussupow A, Raltchev K, Goricanec D, Fleisch M, Sarkar R, Xue K, Aichler M, Mettenleiter G, Walch AK, Camilloni C, Hagn F, Reif B, Ramamoorthy A. Elife. 2017 Nov 17;6. pii: e31226.

 

MobiDB 3.0: more annotations for intrinsic disorder, conformational diversity and interactions in proteins. Piovesan D, Tabaro F, Paladin L, Necci M, Micetic I, Camilloni C, Davey N, Dosztányi Z, Mészáros B, Monzon AM, Parisi G, Schad E, Sormanni P, Tompa P, Vendruscolo M, Vranken WF, Tosatto SCE. Nucleic Acids Res. 2017 Nov 10.

 

Gelsolin pathogenic Gly167Arg mutation promotes domain-swap dimerization of the protein. Bonì F, Milani M, Barbiroli A, Diomede L, Mastrangelo E, de Rosa M. Hum Mol Genet. 2017 Oct 23.

 

Infection with Burkholderia pseudomallei - immune correlates of survival in acute melioidosis. Dunachie SJ, Jenjaroen K, Reynolds CJ, Quigley KJ, Sergeant R, Sumonwiriya M, Chaichana P, Chumseng S, Ariyaprasert P, Lassaux P, Gourlay L, Promwong C, Teparrukkul P, Limmathurotsakul D, Day NPJ, Altmann DM, Boyton RJ. Sci Rep. 2017 Sep 22;7(1):12143.

 

Cellulose production is coupled to sensing of the pyrimidine biosynthetic pathway via c-di-GMP production by the DgcQ protein of Escherichia coli. Rossi E, Motta S, Aliverti A, Cossu F, Gourlay L, Mauri P, Landini P. Environ Microbiol. 2017 Sep 11.

 

Fusicoccin Activates KAT1 Channels by Stabilizing their Interaction with 14-3-3- Proteins.  Saponaro A, Porro A, Chaves-Sanjuan A, Nardini M, Rauh O, Thiel G, Moroni A. Plant Cell. 2017 Sep 29.

 

Target highlights from the first post-PSI CASP experiment (CASP12, May-August 2016). Kryshtafovych A, Albrecht R, Baslé A, Bule P, Caputo AT, Carvalho AL, Chao KL, Diskin R, Fidelis K, Fontes CMGA, Fredslund F, Gilbert HJ, Goulding CW, Hartmann MD, Hayes CS, Herzberg O, Hill JC, Joachimiak A, Kohring GW, Koning RI, Lo Leggio L, Mangiagalli M, Michalska K, Moult J, Najmudin S, Nardini M, Nardone V, Ndeh D, Nguyen TH, Pintacuda G, Postel S, van Raaij MJ, Roversi P, Shimon A, Singh AK, Sundberg EJ, Tars K, Zitzmann N, Schwede T. Proteins. 2017 Sep 28.

 

Structure and Computation in Immunoreagent Design: From Diagnostics to Vaccines. Gourlay L, Peri C, Bolognesi M, Colombo G. Trends Biotechnol. 2017 Jul 21.

 

Designing Probes for Immunodiagnostics: Structural Insights into an Epitope Targeting Burkholderia Infections. Capelli R, Matterazzo E, Amabili M, Peri C, Gori A, Gagni P, Chiari M, Lertmemongkolchai G, Cretich M, Bolognesi M, Colombo G, Gourlay LJ. ACS Infect Dis. 2017 Oct 13;3(10):736-743.

 

Integrative structural and dynamical biology with PLUMED-ISDB. Bonomi M, Camilloni C. Bioinformatics. 2017 Aug 21.

 

Sequence Specificity in the Entropy-Driven Binding of a Small Molecule and a Disordered Peptide. Heller GT, Aprile FA, Bonomi M, Camilloni C, De Simone A, Vendruscolo M. J Mol Biol. 2017 Sep 1;429(18):2772-2779.

 

Structural bases of the altered catalytic properties of a pathogenic variant of apoptosis inducing factor. Sorrentino L, Cossu F, Milani M, Aliverti A, Mastrangelo E. Biochem Biophys Res Commun. 2017 Jun 27. pii: S0006-291X(17)31287-1. doi: 10.1016/j.bbrc.2017.06.156.

 

FRET studies of various conformational states adopted by transthyretin. Ghadami SA, Bemporad F, Sala BM, Tiana G, Ricagno S, Chiti F. Cell Mol Life Sci. 2017 May 6. doi: 10.1007/s00018-017-2533-x.

 

Structural Characterization of the Early Events in the Nucleation-Condensation Mechanism in a Protein Folding Process. Kukic P, Pustovalova Y, Camilloni C, Gianni S, Korzhnev DM, Vendruscolo M. J Am Chem Soc. 2017 May 24;139(20):6899-6910. doi: 10.1021/jacs.7b01540.

 

Boosting of post-exposure human T-cell and B-cell recall responses in vivo by Burkholderia pseudomallei-related proteins. Nithichanon A, Gourlay LJ, Bancroft GJ, Ato M, Takahashi Y, Lertmemongkolchai G. Immunology. 2017 May;151(1):98-109. doi: 10.1111/imm.12709. Epub 2017 Feb 9.

 

Crystal Structure of the Arabidopsis thaliana L1L/NF-YC3 Histone-fold Dimer Reveals Specificities of the LEC1 Family of NF-Y Subunits in Plants. Gnesutta N, Saad D, Chaves-Sanjuan A, Mantovani R, Nardini M. Mol Plant. 2017 Apr 3;10(4):645-648. doi: 10.1016/j.molp.2016.11.006.

 

Metadynamic metainference: Convergence towards force field independent structural ensembles of a disordered peptide. Löhr T, Jussupow A, Camilloni C. J Chem Phys. 2017 Apr 28;146(16):165102. doi: 10.1063/1.4981211.

 

Emergence and evolution of an interaction between intrinsically disordered proteins. Hultqvist G, Åberg E, Camilloni C, Sundell GN, Andersson E, Dogan J, Chi CN, Vendruscolo M, Jemth P. Elife. 2017 Apr 11;6. pii: e16059. doi: 10.7554/eLife.16059.

 

Simultaneous quantification of protein order and disorder. Sormanni P, Piovesan D, Heller GT, Bonomi M, Kukic P, Camilloni C, Fuxreiter M, Dosztanyi Z, Pappu RV, Babu MM, Longhi S, Tompa P, Dunker AK, Uversky VN, Tosatto SC, Vendruscolo M. Nat Chem Biol. 2017 Mar 22;13(4):339-342. doi: 10.1038/nchembio.2331.

 

An Asp to Asn mutation is a toxic trigger in beta-2 microglobulin: structure and biophysics. de Rosa M, Halabelian L, Barbiroli A, Bolognesi M, Bellotti V, Ricagno S. Amyloid. 2017 Mar;24(sup1):15-16. doi: 10.1080/13506129.2016.1272450.

 

Networks of Dynamic Allostery Regulate Enzyme Function. Holliday MJ, Camilloni C, Armstrong GS, Vendruscolo M, Eisenmesser EZ. Structure. 2017 Feb 7;25(2):276-286. doi: 10.1016/j.str.2016.12.003.

 

Principles of protein structural ensemble determination. Bonomi M, Heller GT, Camilloni C, Vendruscolo M. Curr Opin Struct Biol. 2017 Feb;42:106-116. doi: 10.1016/j.sbi.2016.12.004.

 

Simultaneous NMR characterisation of multiple minima in the free energy landscape of an RNA UUCG tetraloop. Borkar AN, Vallurupalli P, Camilloni C, Kay LE, Vendruscolo M. Phys Chem Chem Phys. 2017 Jan 25;19(4):2797-2804. doi: 10.1039/c6cp08313g.

 

 

 

 

 

 

Publications

Last update 31/01/19

The Structural Biology Group comprises members from both the DBS-UNIMI and the IBF-CNR. The content herein is not regulated by the University of Milan.