Publications

2019

 

Structure-Activity Relationship of NF023 Derivatives Binding to XIAP-BIR1. Sorrentino L, Cossu F, Milani M, Malkoc B, Huang WC, Tsay SC, Ru Hwu J, Mastrangelo E. ChemistryOpen. 2019 Apr 12;8(4):476-482. doi: 10.1002/open.201900059. eCollection 2019 Apr. PMID: 31011505

 

Structural and functional characterization of TgpA, a critical protein for the viability of Pseudomonas aeruginosa. Uruburu M, Mastrangelo E, Bolognesi M, Ferrara S, Bertoni G, Milani M. J Struct Biol. 2019 Mar 1;205(3):18-25. doi: 10.1016/j.jsb.2018.12.004. Epub 2018 Dec 30. PMID: 30599211

 

Broad spectrum anti-flavivirus pyridobenzothiazolones leading to less infective virions. Cannalire R, Tarantino D, Piorkowski G, Carletti T, Massari S, Felicetti T, Barreca ML, Sabatini S, Tabarrini O, Marcello A, Milani M, Cecchetti V, Mastrangelo E, Manfroni G, Querat G. Antiviral Res. 2019 Mar 5. pii: S0166-3542(18)30738-1. doi: 10.1016/j.antiviral.2019.03.004. [Epub ahead of print] PMID: 30849420

 

Investigating the Molecular Basis of the Aggregation Propensity of the Pathological D76N Mutant of Beta-2 Microglobulin: Role of the Denatured State. Visconti L, Malagrino F, Broggini L, De Luca CMG, Moda F, Gianni S, Ricagno S, Toto A. Int J Mol Sci. 2019 Jan 18;20(2). pii: E396. doi: 10.3390/ijms20020396. PMID: 30669253

 

Targeting the BIR Domains of Inhibitor of Apoptosis (IAP) Proteins in Cancer Treatment. Cossu F, Milani M, Mastrangelo E, Lecis D. Comput Struct Biotechnol J. 2019 Jan 25;17:142-150. doi: 10.1016/j.csbj.2019.01.009. eCollection 2019. Review. PMID: 30766663

 

Nanobody interaction unveils structure, dynamics and proteotoxicity of the Finnish-type amyloidogenic gelsolin variant. Giorgino T, Mattioni D, Hassan A, Milani M, Mastrangelo E, Barbiroli A, Verhelle A, Gettemans J, Barzago MM, Diomede L, de Rosa M. Biochim Biophys Acta Mol Basis Dis. 2019 Jan 6. pii: S0925-4439(19)30010-9. doi: 10.1016/j.bbadis.2019.01.010. [Epub ahead of print]

 

A superposition free method for protein conformational ensemble analyses and local clustering based on a differential geometry representation of backbone. Marinho da Silva Neto A, Silva SR, Vendruscolo M, Camilloni C, Montalvao RW. Proteins. 2019 Apr;87(4):302-312. doi: 10.1002/prot.25652. Epub 2019 Feb 5. PMID: 30582223

 

A structurally heterogeneous transition state underlies coupled binding and folding of disordered proteins. Karlsson E, Andersson E, Dogan J, Gianni S, Jemth P, Camilloni C. J Biol Chem. 2019 Jan 25;294(4):1230-1239. doi: 10.1074/jbc.RA118.005854. Epub 2018 Dec 4. PMID: 30514761

 

 

2018

 

Strategic single point mutation yields a solvent- and salt-stable transaminase from Virgibacillus sp. in soluble form. Guidi B, Planchestainer M, Contente ML, Laurenzi T, Eberini I, Gourlay LJ, Romano D, Paradisi F, Molinari F. Sci Rep. 2018 Nov 6;8(1):16441. doi: 10.1038/s41598-018-34434-3. PMID: 30401905

 

The phosphorylatable Ser320 of NF-YA is involved in DNA binding of the NF-Y trimer. Bernardini A, Lorenzo M, Nardini M, Mantovani R, Gnesutta N. FASEB J. 2018 Dec 27:fj201801989R. doi: 10.1096/fj.201801989R. [Epub ahead of print]

 

The Antibody Light-Chain Linker Regulates Domain Orientation and Amyloidogenicity. Weber B, Hora M, Kazman P, Gobl C, Camilloni C, Reif B, Buchner J. J Mol Biol. 2018 Dec 7;430(24):4925-4940. doi: 10.1016/j.jmb.2018.10.024. Epub 2018 Nov 8.

 

Identification of Plasmodium berghei Oocyst Rupture Protein 2 (ORP2) domains involved in sporozoite egress from the oocyst. Siden-Kiamos I, Pace T, Klonizakis A, Nardini M, Garcia CRS, Curra C. Int J Parasitol. 2018 Nov 2. pii: S0020-7519(18)30247-9. doi: 10.1016/j.ijpara.2018.09.004. [Epub ahead of print]

 

A stereospecific carboxyl esterase from Bacillus coagulans hosting nonlipase activity within a lipase-like fold. De Vitis V, Nakhnoukh C, Pinto A, Contente ML, Barbiroli A, Milani M, Bolognesi M, Molinari F, Gourlay LJ, Romano D. FEBS J. 2018 Mar;285(5):903-914. doi: 10.1111/febs.14368. Epub 2018 Jan 11.

 

Systematic mapping of free energy landscapes of a growing filamin domain during biosynthesis. Waudby CA, Wlodarski T, Karyadi ME, Cassaignau AME, Chan SHS, Wentink AS, Schmidt-Engler JM, Camilloni C, Vendruscolo M, Cabrita LD, Christodoulou J. Proc Natl Acad Sci U S A. 2018 Sep 25;115(39):9744-9749. doi: 10.1073/pnas.1716252115. Epub 2018 Sep 10.

 

Saturn-Shaped Ice Burst Pattern and Fast Basal Binding of an Ice-Binding Protein from an Antarctic Bacterial Consortium. Kaleda A, Haleva L, Sarusi G, Pinsky T, Mangiagalli M, Bar Dolev M, Lotti M, Nardini M, Braslavsky I. Langmuir. 2018 Sep 26. doi: 10.1021/acs.langmuir.8b01914. [Epub ahead of print]

 

A Single Nucleoside Viral Polymerase Inhibitor Against Norovirus, Rotavirus, and Sapovirus-Induced Diarrhea. Van Dycke J, Arnoldi F, Papa G, Vandepoele J, Burrone OR, Mastrangelo E, Tarantino D, Heylen E, Neyts J, Rocha-Pereira J. J Infect Dis. 2018 Jul 31. doi: 10.1093/infdis/jiy398. [Epub ahead of print]

 

Structure-based design and molecular profiling of Smac-mimetics selective for cellular IAPs. Corti A, Milani M, Lecis D, Seneci P, de Rosa M, Mastrangelo E, Cossu F. FEBS J. 2018 Sep;285(17):3286-3298. doi: 10.1111/febs.14616. Epub 2018 Aug 16.

 

Role and inhibition of GLI1 protein in cancer. Mastrangelo E, Milani M. Lung Cancer (Auckl). 2018 Mar 27;9:35-43. doi: 10.2147/LCTT.S124483. eCollection 2018. Review.

 

Structure of a bacterial ice binding protein with two faces of interaction with ice. Mangiagalli M, Sarusi G, Kaleda A, Bar Dolev M, Nardone V, Vena VF, Braslavsky I, Lotti M, Nardini M. FEBS J. 2018 May;285(9):1653-1666. doi: 10.1111/febs.14434. Epub 2018 Apr 10.

 

Conformational dynamics in crystals reveal the molecular bases for D76N beta-2 microglobulin aggregation propensity. Le Marchand T, de Rosa M, Salvi N, Sala BM, Andreas LB, Barbet-Massin E, Sormanni P, Barbiroli A, Porcari R, Sousa Mota C, de Sanctis D, Bolognesi M, Emsley L, Bellotti V, Blackledge M, Camilloni C, Pintacuda G, Ricagno S. Nat Commun. 2018 Apr 25;9(1):1658. doi: 10.1038/s41467-018-04078-y.

 

Target highlights from the first post-PSI CASP experiment (CASP12, May-August 2016). Kryshtafovych A, Albrecht R, Baslé A, Bule P, Caputo AT, Carvalho AL, Chao KL, Diskin R, Fidelis K, Fontes CMGA, Fredslund F, Gilbert HJ, Goulding CW, Hartmann MD, Hayes CS, Herzberg O, Hill JC, Joachimiak A, Kohring GW, Koning RI, Lo Leggio L, Mangiagalli M, Michalska K, Moult J, Najmudin S, Nardini M, Nardone V, Ndeh D, Nguyen TH, Pintacuda G, Postel S, van Raaij MJ, Roversi P, Shimon A, Singh AK, Sundberg EJ, Tars K, Zitzmann N, Schwede T. Proteins. 2018 Mar;86 Suppl 1:27-50. doi: 10.1002/prot.25392. Epub 2017 Oct 16.

 

Functionalized 2,1-benzothiazine 2,2-dioxides as new inhibitors of Dengue NS5 RNA-dependent RNA polymerase. Cannalire R, Tarantino D, Astolfi A, Barreca ML, Sabatini S, Massari S, Tabarrini O, Milani M, Querat G, Mastrangelo E, Manfroni G, Cecchetti V. Eur J Med Chem. 2018 Jan 1;143:1667-1676. doi: 10.1016/j.ejmech.2017.10.064. Epub 2017 Nov 11.

 

Gelsolin pathogenic Gly167Arg mutation promotes domain-swap dimerization of the protein. Boni F, Milani M, Barbiroli A, Diomede L, Mastrangelo E, de Rosa M. Hum Mol Genet. 2018 Jan 1;27(1):53-65. doi: 10.1093/hmg/ddx383.

 

MobiDB 3.0: more annotations for intrinsic disorder, conformational diversity and interactions in proteins. Piovesan D, Tabaro F, Paladin L, Necci M, Micetic I, Camilloni C, Davey N, Dosztányi Z, Mészáros B, Monzon AM, Parisi G, Schad E, Sormanni P, Tompa P, Vendruscolo M, Vranken WF, Tosatto SCE. Nucleic Acids Res. 2018 Jan 4;46(D1):D471-D476. doi: 10.1093/nar/gkx1071.

 

Folding Mechanism of the SH3 Domain from Grb2. Troilo F, Bonetti D, Camilloni C, Toto A, Longhi S, Brunori M, Gianni S. J Phys Chem B. 2018 Aug 23. doi: 10.1021/acs.jpcb.8b06320. [Epub ahead of print]

 

Determination of the conformational states of strychnine in solution using NMR residual dipolar couplings in a tensor-free approach. Tomba G, Camilloni C, Vendruscolo M. Methods. 2018 Sep 15;148:4-8. doi: 10.1016/j.ymeth.2018.07.005. Epub 2018 Jul 21.

 

Molecular dynamics ensemble refinement of the heterogeneous native state of NCBD using chemical shifts and NOEs. Papaleo E, Camilloni C, Teilum K, Vendruscolo M, Lindorff-Larsen K. PeerJ. 2018 Jul 4;6:e5125. doi: 10.7717/peerj.5125. eCollection 2018.

 

Structural basis for terminal loop recognition and stimulation of pri-miRNA-18a processing by hnRNP A1. Kooshapur H, Choudhury NR, Simon B, Mühlbauer M, Jussupow A, Fernandez N, Jones AN, Dallmann A, Gabel F, Camilloni C, Michlewski G, Caceres JF, Sattler M. Nat Commun. 2018 Jun 26;9(1):2479. doi: 10.1038/s41467-018-04871-9.

 

A method for partitioning the information contained in a protein sequence between its structure and function. Possenti A, Vendruscolo M, Camilloni C, Tiana G. Proteins. 2018 May 23. doi: 10.1002/prot.25527. [Epub ahead of print]

 

An implementation of the maximum-caliber principle by replica-averaged time-resolved restrained simulations. Capelli R, Tiana G, Camilloni C. J Chem Phys. 2018 May 14;148(18):184114. doi: 10.1063/1.5030339.

 

The PHR Family: The Role of Extracellular Transglycosylases in Shaping Candida albicans Cells. Popolo L, Degani G, Camilloni C, Fonzi WA. J Fungi (Basel). 2017 Oct 29;3(4). pii: E59. doi: 10.3390/jof3040059. Review.

 

Last update 29/06/19

The Structural Biology Group comprises members from both the DBS-UNIMI and the IBF-CNR. The content herein is not regulated by the University of Milan.