The structure of N184K amyloidogenic variant of gelsolin highlights the role of the H-bond network for protein stability and aggregation properties. de Rosa M, Barbiroli A, Boni F, Scalone E, Mattioni D, Vanoni MA, Patrone M, Bollati M, Mastrangelo E, Giorgino T, Milani M. Eur Biophys J. 2019 Nov 13. doi: 10.1007/s00249-019-01409-9. PMID: 31724080


Cas9 Allosteric Inhibition by the Anti-CRISPR Protein AcrIIA6. Fuchsbauer O, Swuec P, Zimberger C, Amigues B, Levesque S, Agudelo D, Duringer A, Chaves-Sanjuan A, Spinelli S, Rousseau GM, Velimirovic M, Bolognesi M, Roussel A, Cambillau C, Moineau S, Doyon Y, Goulet A. Mol Cell. 2019 Sep 26. pii: S1097-2765(19)30697-5. doi: 10.1016/j.molcel.2019.09.012. PMID: 31604602


Structural and functional characterization of the globin-coupled sensors of Azotobacter vinelandii and Bordetella pertussis.Germani F, Nardini M, De Schutter A, Cuypers B, Berghmans H, Van Hauwaert ML, Stefano B, Mozzarelli A, Moens L, Van Doorslaer S, Bolognesi M, Pesce A, Dewilde S. Antioxid Redox Signal. 2019 Sep 27. doi: 10.1089/ars.2018.7690. PMID:31559835


Martini bead form factors for nucleic-acids and their application in the refinement of protein/nucleic-acid complexes against SAXS data. Paissoni C., Jussupow A., and Camilloni C. (2019). J. APPL. CRYST. 52: 394-402


Cryo-EM Structures of Azospirillum brasilense Glutamate Synthase in its Oligomeric Assemblies. Swuec P, Chaves-Sanjuan A, Camilloni C, Vanoni MA, Bolognesi M. J Mol Biol. 2019 Aug 29. pii: S0022-2836(19)30520-0. doi: 10.1016/j.jmb.2019.08.011. [Epub ahead of print] PMID:31473159


Modulating the cardiotoxic behaviour of immunoglobulin light chain dimers through point mutations. Maritan M, Ambrosetti A, Oberti L, Barbiroli A, Diomede L, Romeo M, Lavatelli F, Sormanni P, Palladini G, Bolognesi M, Merlini G, Ricagno S. Amyloid. 2019;26(sup1):105-106. doi: 10.1080/13506129.2019.1583185. PMID: 31343361


High-resolution crystal structure of gelsolin domain 2 in complex with the physiological calcium ion. Bollati M, Scalone E, Boni F, Mastrangelo E, Giorgino T, Milani M, de Rosa M. Biochem Biophys Res Commun. 2019 Oct 8;518(1):94-99. doi: 10.1016/j.bbrc.2019.08.013. Epub 2019 Aug 12. PMID:    31416615


The concurrency of several biophysical traits links immunoglobulin light chains with toxicity in AL amyloidosis. Oberti L, Maritan M, Rognoni P, Barbiroli A, Lavatelli F, Russo R, Palladini G, Bolognesi M, Merlini G, Ricagno S. Amyloid. 2019;26(sup1):107-108. doi: 10.1080/13506129.2019.1583187. PMID:31343357


Cryo-EM structure of cardiac amyloid fibrils from an immunoglobulin light chain AL amyloidosis patient. Swuec P, Lavatelli F, Tasaki M, Paissoni C, Rognoni P, Maritan M, Brambilla F, Milani P, Mauri P, Camilloni C, Palladini G, Merlini G, Ricagno S, Bolognesi M. Nat Commun. 2019 Mar 20;10(1):1269. doi: 10.1038/s41467-019-09133-w. PMID: 30894521


Biochemical and biophysical comparison of human and mouse beta-2 microglobulin reveals the molecular determinants of low amyloid propensity. Achour A, Broggini L, Han X, Sun R, Santambrogio C, Buratto J, Visentin C, Barbiroli A, De Luca CMG, Sormanni P, Moda F, De Simone A, Sandalova T, Grandori R, Camilloni C, Ricagno S. FEBS J. 2019 Aug 17. doi: 10.1111/febs.15046. [Epub ahead of print] PMID:  31420997


An alternative non-proteolytic mechanism may underlie AGel amyloidosis. Boni F, Milani M, Mastrangelo E, Babiroli A, Diomede L, de Rosa M. Amyloid. 2019;26(sup1):150-151. doi: 10.1080/13506129.2019.1582510. PMID:   31343311


A Practical Guide to the Simultaneous Determination of Protein Structure and Dynamics Using Metainference. Löhr T, Camilloni C, Bonomi M, Vendruscolo M. Methods Mol Biol. 2019;2022:313-340. doi: 10.1007/978-1-4939-9608-7_13. PMID:   31396909


Promoting transparency and reproducibility in enhanced molecular simulations. PLUMED consortium. Nat Methods. 2019 Aug;16(8):670-673. doi: 10.1038/s41592-019-0506-8. PMID:   31363226


A superposition free method for protein conformational ensemble analyses and local clustering based on a differential geometry representation of backbone. da Silva Neto AM, Silva SR, Vendruscolo M, Camilloni C, Montalvão RW. Proteins. 2019 Apr;87(4):302-312. doi: 10.1002/prot.25652. Epub 2019 Feb 5. PMID:    30582223


Widely applicable background depletion step enables transaminase evolution through solid-phase screening. Planchestainer M, Hegarty E, Heckmann CM, Gourlay LJ, Paradisi F. Chem Sci. 2019 May 9;10(23):5952-5958. doi: 10.1039/c8sc05712e. eCollection 2019 Jun 21. PMID:   31360401


Structure-Activity Relationship of NF023 Derivatives Binding to XIAP-BIR1. Sorrentino L, Cossu F, Milani M, Malkoc B, Huang WC, Tsay SC, Ru Hwu J, Mastrangelo E. ChemistryOpen. 2019 Apr 12;8(4):476-482. doi: 10.1002/open.201900059. eCollection 2019 Apr. PMID: 31011505


Structural and functional characterization of TgpA, a critical protein for the viability of Pseudomonas aeruginosa. Uruburu M, Mastrangelo E, Bolognesi M, Ferrara S, Bertoni G, Milani M. J Struct Biol. 2019 Mar 1;205(3):18-25. doi: 10.1016/j.jsb.2018.12.004. Epub 2018 Dec 30. PMID: 30599211


Broad spectrum anti-flavivirus pyridobenzothiazolones leading to less infective virions. Cannalire R, Tarantino D, Piorkowski G, Carletti T, Massari S, Felicetti T, Barreca ML, Sabatini S, Tabarrini O, Marcello A, Milani M, Cecchetti V, Mastrangelo E, Manfroni G, Querat G. Antiviral Res. 2019 Mar 5. pii: S0166-3542(18)30738-1. doi: 10.1016/j.antiviral.2019.03.004. [Epub ahead of print] PMID: 30849420


Investigating the Molecular Basis of the Aggregation Propensity of the Pathological D76N Mutant of Beta-2 Microglobulin: Role of the Denatured State. Visconti L, Malagrino F, Broggini L, De Luca CMG, Moda F, Gianni S, Ricagno S, Toto A. Int J Mol Sci. 2019 Jan 18;20(2). pii: E396. doi: 10.3390/ijms20020396. PMID: 30669253


Targeting the BIR Domains of Inhibitor of Apoptosis (IAP) Proteins in Cancer Treatment. Cossu F, Milani M, Mastrangelo E, Lecis D. Comput Struct Biotechnol J. 2019 Jan 25;17:142-150. doi: 10.1016/j.csbj.2019.01.009. eCollection 2019. Review. PMID: 30766663


Nanobody interaction unveils structure, dynamics and proteotoxicity of the Finnish-type amyloidogenic gelsolin variant. Giorgino T, Mattioni D, Hassan A, Milani M, Mastrangelo E, Barbiroli A, Verhelle A, Gettemans J, Barzago MM, Diomede L, de Rosa M. Biochim Biophys Acta Mol Basis Dis. 2019 Jan 6. pii: S0925-4439(19)30010-9. doi: 10.1016/j.bbadis.2019.01.010. [Epub ahead of print]


A structurally heterogeneous transition state underlies coupled binding and folding of disordered proteins. Karlsson E, Andersson E, Dogan J, Gianni S, Jemth P, Camilloni C. J Biol Chem. 2019 Jan 25;294(4):1230-1239. doi: 10.1074/jbc.RA118.005854. Epub 2018 Dec 4. PMID: 30514761





Last update 07/12/19

The Structural Biology Group comprises members from both the DBS-UNIMI and the IBF-CNR. The content herein is not regulated by the University of Milan.