Research

 

The Structural Biology Group targets diverse proteins involved in a variety of biochemical pathways, ranging from bacterial antigens, viral enzymes and transcription factors, to proteins involved in apoptosis and amyloidosis-related diseases. Our efforts focus on the development of synthetic inhibitors, immunodiagnostic tools and vaccine components to target their related human pathologies.

As no single technique can provide a complete description of the structure-function relationships of protein complexes, combining data from a variety of biophysical methods is crucial to our understanding of molecular function. The expertise and knowledge within the Structural Biology Group, which spans from X-ray crystallography and Small-angle X-ray Scattering (SAXS) to computational biophysics, has been recently enriched by the newly established Cryo-Electron Microscopy Lab.

 

 

Funding sources

Bolognesi Lab

 

Senior group coordinator

Camilloni Lab

 

Computational Modelling, protein dynamics and molecular recognition

Gourlay Lab

 

Structural Vaccinology studies of protein antigens

Nardini Lab

 

Transcription factors and enzymes complexes

Ricagno Lab

 

Aggregation-prone proteins and amyloidosis

Structural Biology Unit @IBF-CNR

 

Proteins involved in human pathologies such as viral infections and tumours

 

 

Last update 10/04/19

The Structural Biology Group comprises members from both the DBS-UNIMI and the IBF-CNR. The content herein is not regulated by the University of Milan.