The Structural Biology Group targets diverse proteins involved in a variety of biochemical pathways, ranging from bacterial antigens, viral enzymes and transcription factors, to proteins involved in apoptosis and amyloidosis-related diseases. Our efforts focus on the development of synthetic inhibitors, immunodiagnostic tools and vaccine components to target their related human pathologies.
As no single technique can provide a complete description of the structure-function relationships of protein complexes, combining data from a variety of biophysical methods is crucial to our understanding of molecular function. The expertise and knowledge within the Structural Biology Group, which spans from X-ray crystallography and Small-angle X-ray Scattering (SAXS) to computational biophysics, has been recently enriched by the newly established Cryo-Electron Microscopy Lab.
Senior group coordinator
Computational Modelling, protein dynamics and molecular recognition
Structural Vaccinology studies of protein antigens
Transcription factors and enzymes complexes
Aggregation-prone proteins and amyloidosis
Proteins involved in human pathologies such as viral infections and tumours