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The laboratory investigates how the environment modifies epigenetic mechanisms, and how epigenetics is related to disease outcomes. Epigenetics, a currently hot topic, is the study of heritable changes in gene expression that occur without a change in the DNA sequence. The laboratory has undertaken pioneering DNA methylation work, examining the effects of a wide range of environmental agents, including air pollution, heavy metals, and organic chemicals. More recently, we have started an investigation on plasmatic extracellular vesicles and microRNAs, aimed at evaluating their role in mediating cardiovascular and respiratory effects of air pollution.
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