Action CM1001: Chemistry of non-enzymatic protein modification – modulation of protein structure and function

 Report of activities for 2013 achieved with support of ACTION CM1001

Special issues

• Special issue on “AGEs and ALEs: chemistry, physiopathology and molecular strategies for their inhibition”

Editors: G. Aldini, T. Grune, G. Bartosz

Papers can be downloaded free of charge at the following url: http://informahealthcare.com/toc/fra/47/S1

 

• Special Issue: Posttranslational Protein Modifications in Biology and Medicine.

Edited by Tilman Grune and Marek Sebela

http://www.sciencedirect.com/science/journal/18743919/92

 

Report of activiteis (MC members in alphabetic order)

 

Name and Surname of the MC member : ALDINI Giancarlo

•    joint publications

1: Aldini G, Vistoli G, Stefek M, Chondrogianni N, Grune T, Sereikaite J,Sadowska-Bartosz I, Bartosz G. Molecular strategies to prevent, inhibit, and degrade advanced glycoxidation and advanced lipoxidation end products. Free Radic Res. 2013 Aug;47 Suppl 1:93-137. doi: 10.3109/10715762.2013.792926. Epub 2013 May 7. Review. PubMed PMID: 23560617.

2: Aldini G, Grune T, Bartosz G. Special issue on “AGEs and ALEs: chemistry,physiopathology and molecular strategies for their inhibition”. Free Radic Res. 2013 Aug;47 Suppl 1:1-2. doi: 10.3109/10715762.2013.819427. PubMed PMID:23841712.

3: Vistoli G, De Maddis D, Cipak A, Zarkovic N, Carini M, Aldini G. Advanced glycoxidation and lipoxidation end products (AGEs and ALEs): an overview of their mechanisms of formation. Free Radic Res. 2013 Aug;47 Suppl 1:3-27. doi: 10.3109/10715762.2013.815348. Review. PubMed PMID: 23767955.

•    publications, talks, posters done/given with support of COST money

Publications

Colzani M, Aldini G, Carini M. Mass spectrometric approaches for the identification and quantification of reactive carbonyl species protein adducts. J Proteomics. 2013 Oct 30;92:28-50. doi: 10.1016/j.jprot.2013.03.030. Epub 2013 Apr 15. PubMed PMID: 23597925.

Talks

Aldini G. High resolution mass spectrometric strategies for studying AGEs inhibitors and RAGE antagonists. SFRR-Europe 2013 conference: The New Era of -omics in Free Radicals in Biology and Medicine. September 23-25, 2-13, Athens, Greece.

• Lectures on the summer school

Lecture: Intact protein analysis

Lecture: Contribution of intact protein analysis for studying oxPTMs

COST CM1001 Aston MS Workshop

Birmingham, UK, 1-5^th July 2013

 

Name and Surname of the MC member : ALMEIDA Henrique

• Joint Publications:

Castro JP, Jung T, Grune T, Almeida H. Actin carbonylation: From cell dysfunction to organism disorder. J Proteomics. 2013, 92: 171 180.

[Direct mention to COST].

• Other Publications:

Guedes-Martins L, Matos L, Soares A, Silva E, Almeida H. AGEs, contributors to placental bed vascular changes leading to preeclampsia. Free Radic Res. 2013 Aug; 47 Suppl 1: 70 80.

[Direct mention to COST].

Neves D (2013) Advanced glycation end-products: a common pathway in diabetes and age-related erectile dysfunction. Free Radic Res. 2013 Aug;47 Suppl 1: 49-69.

[Non direct mention COST in this paper; is part of a special Free Rad Res. issue with COST involvement; Dr. Neves is a member of my research group actually]. I leave to your consideration its inclusion or not.

•  International presentations:

Castro, JP, Jung, T, Grune, T., Almeida, H. Heat Shock Protein 90 role in oxidized protein aggregates. upcoming SFFR Europe Meeting “The new era of -omics in Free Radicals in Biology and Medicine” Athens 23-26^th September 2013

[Direct support from COST].

 

• Presentations in Portugal:

Castro, JP, Jung, T, Grune, T., Almeida, H. Heat Shock Protein 90 role in oxidized protein aggregates. 3^rd Faculty of Medicine of Porto PhD Students Meeting, December 11^th 2013, Porto.

[Mention to COST support].

 

• Prizes and Awards

José Pedro Castro presentation «Heat Shock Protein 90 role in oxidized protein aggregates» at the 3^rd Faculty of Medicine of Porto PhD Students Meeting was selected as the best and awarded the presence at the International Medical Postgraduate Conference, annually held at the Charles University, Prague, Czech Republic.

[Will mention COST support to his work].

 

• Abstract:

Castro, JP, Jung, T, Grune, T., Almeida, H. Heat Shock Protein 90 role in oxidized protein aggregates. SFFR Europe Meeting “The new era of -omics in Free Radicals in Biology and Medicine” Athens 23-26^th September 2013

[Direct support from COST].

 

• STSM:

Dalila Fernandes at Andreas Simm lab (Germany) in May/June 2013.

[Direct support from COST].

 

Name and Surname of the MC member : ATALAY Mustafa

•    publications, talks, posters done/given with support of COST money

1. Venojärvi M, Korkmaz A., Aunola S, Hällsten K, Virtanen K, Marniemi J, Halonen J-P, Hänninen O, Nuutila P, Atalay M. Decreased thioredoxin-1 and increased HSP90 expression in skeletal muscle in type 2 diabetes compared with impaired glucose tolerance, BioMed Research International, in press 2013.
2. Venojärvi M, Korkmaz A, Wasenius N, Manderoos S, Heinonen O, Lindholm H, Aunola S, Eriksson JG, Atalay M. 12 weeks aerobic and resistance training did not decrease  lipid and protein oxidation but aerobic training decreases atherogenic index in middle-aged men with impaired glucose regulation, Food and Chemical Toxicology, 2013 2013 Nov;61:127-35.

 

Name and Surname of the MC member : BARTOSZ G.

• Papers

Molecular strategies to prevent, inhibit, and degrade advanced glycoxidation and advanced lipoxidation end products.

Aldini G, Vistoli G, Stefek M, Chondrogianni N, Grune T, Sereikaite J, Sadowska-Bartosz I, Bartosz G.

Free Radic Res. 2013 Aug;47 Suppl 1:93-137.

 

Special issue on “AGEs and ALEs: chemistry, physiopathology and molecular strategies for their inhibition”.

Aldini G, Grune T, Bartosz G.

Free Radic Res. 2013 Aug;47 Suppl 1:1-2.

• Edition of a book

Food Oxidants and Antioxidants. Chemical, Biological and Functional Properties. Edited by Grzegorz Bartosz, CRC Press, Boca Raton, London, New York 2013. 550 s.

• Communication at conferences:

Strategic Interest Group Meeting, COST Action CM1001, Jerusalem, 2013.01.12-14 Lecture: G. Bartosz, Izabela Sadowska-Bartosz: “Prevention of protein damage by lipoxidation”

8th Forum on Oxidative Stress and Aging, Bologna,  2013.06.12-13 Lecture: Izabela Sadowska-Bartosz, G. Bartosz: Lecture: „Prevention of posttranslational protein modifications”

SFRR-Europe 2013 Conference, Athens, 2013.9.23-25. Lecture: G. Aldini, N. Chondrogianni, T. Grune, Izabela Sadowska-Bartosz,  J. Sereikaite, M. Stefek, G. Vistoli, G. Bartosz: “Strategies to prevent posttranslational protein modifications”

IX International Workshop on EPR (ESR) in Biology and Medicine, Kraków, 2013.10.7-10 Lecture: Izabela Sadowska-Bartosz, G. Bartosz: „Oxidative modifications of proteins”

5^th International Symposium: Nutrition, Oxygen Biology and Medicine, Paris, June 5-7. Poster: Sadowska-Bartosz, R. Adamczyk, M. Soszyński, G. Bartosz: Protection against peroxynitrite reactions by flavonoids.

 

Name and Surname of the MC member : FEDOROVA Maria

• Presentations

Protein carbonylation and lipid peroxidation – new analytical techniques

Maria Fedorova

COST Action CM 1001 Strategic Group Meeting “Lipid peroxidation by-products in metabolic diseases”

Jerusalem, Israel, 13^th of January,  2013

 

Integrating lipidomics and proteomics in oxidative stress research

Maria Fedorova

Stress and Ageing: from Molecular Biology to Clinical Perspectives

Halle (Saale), Germany, 7^th of September,  2013

 

Multi-omics  techniques  in  oxidative  stress research: Connecting protein and lipid oxidation

Maria Fedorova

SFRR-Europe 2013

Athens, Greece, September 23rd– 24th,  2013

 

• Lectures on the summer school

Lecture 1: Sample preparation and proteomics workflow

Lecture 2: Basic principles of mass spectrometry and protein analysis

Lecture 3: Strength and limitations of statistical search software

Lecture 4: Tagging and affinity strategies for enrichment or analysis

Seminar: MASCOT for protein identification

Maria Fedorova

COST CM1001 Aston MS Workshop

Birmingham, UK, 1-5^th July 2013

 

• COST Visiting students and Professors

 

Tania Melo

Department of Chemistry, Aveiro University, Portugal

2-29 June 2013

 

Prof. Dr. Rosário Domingues

Department of Chemistry, Aveiro University, Portugal

2-7 June 2013

 

Sarit Anavi

The Robert H. Smith Faculty of Agriculture, Food and Environment, Institute of Biochemistry, Food Science and Nutrition, The Hebrew University of Jerusalem, Rehovot, Israel

21 July – 16 October 2013

 

Alessandra Altomare

Pharmaceuticl chemistry, Department of Pharmaceutical Sciences, University of Milan

1 October – 7 December 2013

 

Name and Surname of the MC member : FRIGUET Bertrand

•    joint publications

Chondrogianni N, Petropoulos I, Grimm S, Georgila K, Catalgol B, Friguet B, Grune T and Gonos ES.

Protein damage, repair and proteolysis. Mol Asp Med 2013 (in press).

 

•    publications, talks, posters done/given with support of COST money

publications

Baraibar MA. Ladouce R, Friguet B. Proteomic quantification and identification of carbonylated proteins upon oxidative stress and during cellular aging. J. Proteomics 2013. 92 : 63-70.

 

Baraibar MA, Friguet B. Oxidative proteome modifications target specific cellular pathways during oxidative stress, cellular senescence and aging. Exp Gerontol. 2013. 48 : 620-625

 

talks

Impairment of energy metabolism is associated with oxidative modifications of specific enzymes in senescent cells.

B. Friguet. COST action CM 1001 Strategic Group Meeting, Jerusalem (Israel), January 12-14, 2013.

 

posters

Compromised cellular metabolism during senescence is associated with the oxidative modification of a restricted set of enzymes.

M.A. Baraibar, J. Hyzewicz ,  A. Rogowska-Wrzesinska , A.L. Bulteau, C. Prip-Buus, G. Butler-Browne, B. Friguet. Stress and Ageing Meeting, Halle (Germany), September 6-8, 2013.

 

Oxidative proteome alterations during skeletal muscle ageing.

S. Santos, M. Baraibar, M. Le Boulch, L. Larsson, B. Friguet. Stress and Ageing Meeting, Halle (Germany), September 6-8, 2013.

 

 

Name and Surname of the MC member : GONOS ES.

• Posters

a) Enhanced proteasome degradation extends Caenorhabditis elegans’ lifespan and ameliorates neurodegeneration

Georgila K.Chondrogianni  N., Kourtis N., Tavernarakis N. and Gonos ES

SFRR-Europe 2013 Conference, Athens, Greece September 23-25 2013.

 

b) Study of the effects of natural compounds in the lifespan of the nematode Caenorhabditis elegans

Nikoletta PAPAEVGENIOU, Marianthi SAKELLARI, Efstathios S. GONOS and Niki CHONDROGIANNI

SFRR-Europe 2013 Conference, Athens, Greece September 23-25 2013.

• Talks

a) Efstathios Gonos

Cost action CM1001 Strategic Group Meeting, Jerusalem (Israel) January 13-14, 2013

 

b) Efstathios Gonos

SFRR-Europe 2013 Conference, Athens, Greece September 23-25 2013.

• Joint publications

1. N. Chondrogianni, I. Petropoulos, S. Grimm, K. Georgila, B. Catalgol, B. Friguet, T. Grune and E.S. Gonos (2013) Protein damage, repair and proteolysis. Mol. Aspects Med., in press

 

• Conference

COST sessions at the SFRR-Europe 2013 Conference, Athens, Greece, September 23-25 2013.

(S3) Prevention of post-translational protein modification and removal of products

Chairs: Niki Chondrogianni & Tilman Grune

Kelvin Davies, “Regulatory Mechanisms for Proteolytic systems in Oxidative Stress”, L.A., U.S.A.

Stathis Gonos, “Proteasome activation as a novel anti-aging strategy”, Athens, Greece

Tilman Grune, “Pathophysiological importance of protein aggregation”, Jena, Germany

Betul Karademir, “Regulation of protein turnover by heat shock proteins”, Istanbul, Turkey

(S6) Physiological and pathophysiological importance of post-translational protein modifications

Chairs: Valerie Vanhooren & Helen Griffiths

Koji Uchida, “Redox-derived damage-associated molecular patterns: Ligand function of lipid peroxidation adducts”, Nagoya, Japan

Andreas Simm, “Physiological and pathophysiological importance of advanced glycation end-products”, Halle, Germany

Greg Bartosz, “Strategies to prevent post-translational protein modifications”, Lodz, Poland

Helen Griffiths, “Intracellular redox state modulates the T cell surface proteome – relevance to ageing”, Birmingham, U.K

 

Name and Surname of the MC member :GRADINARU Daniela

•    joint publications

Gradinaru D, Borsa C, Ionescu C, Margina D. Advanced oxidative and glycoxidative protein damage markers in the elderly with type 2 diabetes. J Proteomics. 2013 Oct 30;92:313-22.

 

Name and Surname of the MC member : GRIFFITHS Helen

•             joint publications

Weber D, Milkovic L, Bennett SJ, Griffiths HR, Zarkovic N, Grune T. Measurement of HNE-protein adducts in human plasma and serum by ELISA-Comparison of two primary antibodies. Redox Biol. 2013 Feb 8;1(1):226-33.

 

Ratnayake S, Dias IH, Lattman E, Griffiths HR. Stabilising cysteinyl thiol oxidation and nitrosation for proteomic analysis. J Proteomics. 2013 Oct 30;92:160-70.

 

Dias IHK, Polidori MC, Li L, Weber, D, Stahl W, Nelles G, Grune T, Griffiths HR. Plasma levels of HDL and carotenoids are lower in dementia patients with vascular comorbidities but plasma protein nitration and oxidation is unaffected. Journal of Alzheimer’s Disease. 2014. accepted.

 

Griffiths HR, Dias IHK, Willetts RS, Devitt A (2014)  Redox Regulation of Protein Damage in Plasma. Redox Biol. 2014. accepted

 

•          publications, talks, posters done/given with support of COST money

Biological relevance of protein oxidation.  H.R.Griffiths. Mass spectrometry workshop, Aston University, 2^nd and 5^th July.

 

Case study on analysis of oxPTMs.  H.R.Griffiths. Mass spectrometry workshop, Aston University, 2^nd and 5^th July.

 

Membrane protein isolation coupled to 2-dimensional electrophoresis and mass spectrometry for ageing biomarker discovery H.R. Griffiths, Halle (Germany), 6-8^th September, 2014.

Intracellular redox state modulates the T cell surface proteome – relevance to ageing. S.J. Griffiths, C.R. Dunston, I.H.K. Dias, R. Carilho, E. Augustyniak, H.R. Griffiths, SFRR-E, Athens (Greece) 23-26^th September, 2014.

 

•             dissemination activities to the general public

None in 2013

 

 

Name and Surname of the MC member : HORAKOVA Ľubica, ŠTEFEK Milan

 

•    joint publications

Aldini G, Vistoli G, Stefek M, Chondrogianni N, Grune T, Sereikaite J, Sadowska-Bartosz I, Bartosz G. Molecular strategies to prevent, inhibit, and degrade advanced glycoxidation and advanced lipoxidation end products. Free Radic Res. 2013 Aug;47 Suppl 1:93-137.

Horakova L,  Strosova MK, Spickett CM,  Blaskovic, D. Impairment of calcium ATPases by high glucose and potential pharmacological protection. Free Radical Research. 2013 Aug;47 Suppl 1: 81-92.

Stefek M, Milackova I, Diez-Dacal B, Pérez-Sala Gozalo D,  Soltesova-Prnova M. Použitie 5-karboxymetyl-3-merkapto-1,2,4-triazino-[5,6-b]indolov a farmaceutický prostriedok s ich  obsahom. Patent Application, Slovakia, PP 97-2013 (2013).

Zizkova P,  Viskupicova J,  Blaskovic D, Strosova MK, Zarkovic N, Horakova L. Sarcoplasmic reticulum Ca2+-ATPase from rabbit skeletal muscle modified by peroxynitrite. Journal of Enzyme Inhibition and Medicinal Chemistry. 2013; publ. online 1-8 p.

 

•    publications, talks, posters done/given with support of COST money

Blaskovic D,  Zizkova P, Drzik F, Viskupicova J,  Veverka M, Horakova L. Modulation of rabbit muscle sarcoplasmic reticulum Ca2+-ATPase activity by novel quercetin derivatives. Interdisciplinary Toxicology, 2013 March; 6(1): 3-8.

Zizkova P, Blaskovic D, Majekova M, Svorc L, Rackova L, Ratkovska L, Veverka M, Horakova L. Novel quercetin derivatives in treatment of peroxynitrite-oxidized SERCA1.  Molecular and Cellular Biochemistry, published online, october 2013.

Preclinical studies of 2-chloro-1,4-naphthoquinone derivative of quercetin, inhibitor of AKR1B1 and AKR1B10. Potential implications in diabetic complications, inflammatory disorders and cancer. I. Milackova, M. Soltesova-Prnova,  M. Majekova, R. Sotnikova, J. Navarova, L. Rackova, Diez-Dacal B, Pérez-Sala D,  Enayat S, Banerjee S, Veverka M,  Stefek  M. International Society of Antioxidants in Nutrition and Health, Bonn (Germany) June 6-7 2013.

2-Chloro-1,4-naphthoquinone derivative of quercetin as an efficient inhibitor of AKR1B1 and AKR1B10. Implications for diabetic complications, inflammatory disorders and cancer. I. Milackova, M. Soltesova-Prnova,  M. Majekova, R. Sotnikova, L. Kovacikova, L. Rackova, B. Diez-Dacal, D. Pérez-Sala, S. Enayat, S. Banerjee, M. Stefek. Free Radical Biology and Medicine, 2013; 65, Suppl 1: p. S50.

Novel quercetin derivatives in treatment of peroxynitrite-oxidized calcium pump. L. Horakova, P. Zizkova, M. Majekova, L. Rackova, M. Veverka, L. Svorc, D. Blaskovic. Free Radical Biology and Medicine, 2013; 65, Suppl 1: p. S34.

Calcium pumps as a possible therapeutic tool for treatment of oxidative stress related diseases. L. Horakova, J. Lomenova, P. Zizkova, V. Klusova, D. Blaskovic. In First International conference on oncology and anticancer research”. “Fourth International conference on recent advances in health and medical sciences”. “Twenty second International conference on chelation”. Paphos (Cyprus), June 2013, p. 43.

 

Name and Surname of the MC member : HOUÉE LEVIN Chantal

•    joint publications

The use of the method of radiolysis to explore the free radical modifications in proteins. Houee-Levin, C.; Bobrowski, K. J.  Proteomics : (2013) .doi.org/10.1016/j.jprot.2013.02.014

•    publications, talks, posters done/given with support of COST money

Oxidation of methionine-containing peptides by OH radicals: Is sulfoxide the only product? Study by mass spectrometry and IRMPD spectroscopy. Marta Ignasiak, Pedro de Oliveira, Chantal Houée Levin, Debora Scuderi
Chemical Physics Letters, 590, 2013, Pages 35-40.

A long story of sensitized one-electron photo-oxidation of Methionine. Ignasiak^,  M., Marciniak, B., Houée-Levin^, C. Isr. J. Chem. 2013 in press

 

Name and Surname of the MC member : NEDIĆ Olgica

•    joint publications

1. Nedić O , Rattan SIS, Grune T, Trougakos IP. Molecular effects of advanced glycation end products on cell signalling pathways, ageing and pathophysiology. Free Radical Research. 2013 Aug; 47(Suppl. 1): 28–38.

2. Submitted for publication (revised article under review): Robajac D, Masnikosa R, Vanhooren V, Libert C, Miković Ž, Nedić O. The N-glycan profile of placental membrane glycoproteins alters during gestation and ageing. Mechanisms of Ageing and Development. MAD-D-13-00093R1.

(results obtained during STSM in 2012: Dragana Robajac in the lab of Valerie Vanhooren)

 

•    publications, talks, posters done/given with support of COST money

1. N-glycan profile of placental membrane glycoproteins changes during gestation and ageing

D. Robajac, R. Masnikosa, V. Vanhooren, C. Libert, Ž. Miković, O. Nedić. 38th FEBS Congress,

St. Petersburg (Russia) July 6-11 2013.

•    workshop participation

1. Goran Miljuš participated in the COST CM1001 Workshop on Mass Spectrometry Analysis of Protein Oxidation, Birmingham (UK) July 1-5 2013.

 

 

Name and Surname of the MC member : PÉREZ-SALA Dolores

•    joint publications

Domingues MR., Domingues P, Melo T, Pérez-Sala D, Reis A, Spickett C. Lipoxidation adducts with peptides and proteins: deleterious modifications or signalling mechanisms? J Proteomics 2013 Oct; 92: 110-131.

 

•    publications, talks, posters done/given with support of COST money

Publications in which support from COST Action is acknowledged:

Oeste CL, Pérez-Sala D. Modification of cysteine residues by cyclopentenone prostaglandins: interplay with redox regulation of protein function Mass Spectrom Rev (In Press) DOI: 10.1002/mas.21383.

 

• Talks:

 

Redox and stress sensing by vimentin

D. Pérez-Sala, AE. Martínez, CL. Oeste, B. Garzón. SFRR Europe Conference 2013 “The new era of –omics in free radical biology and medicine”. Athens. Greece. September 23-25, 2013.

 

Other joint activities (posters and patent) with the group of Prof. Milan Stefek (Slovakia) are detailed in his report.

 

 

Name and Surname of the MC member : LARSSON Lars

•    joint publications

Qaisar, R., Renaud, G., Hedstrom, Y., Pöllänen, E., Ronkainen², Kaprio, M., Alen, M., Sipilä, S., Artemenko, K., Bergquist, J., Sippilä, S., Kovanen, V., Larsson, L. Contractile properties and myonyclear organization in single muscle fibers in postmenopausal monozygous twin pairs discordant for hormone replacement therapy.  Journal of Physiology.2013. 1;591(Pt 9):2333-44

•    publications, talks, posters done/given with support of COST money

Ramamurthy, B. Larsson, L. Detection of an Aging-Related increase in Advanced Glycation Endproducts in Fast- and Slow-Twitch Skeletal Muscles in the Rat.  J Biogerontol. 2013. 14:293-301.

Aare, S. Radell, P., Eriksson, L.I.,  Akkad, H., Chen, Y.W., Hoffman, E.P., Larsson,L. 2013Effects of corticosteroids in the development of limb muscle weakness in a porcine intensive care unit model. Physiological Genomics. 2013.45(8):312-20

Banduseela, V.C., Chen, Y.W, Göransson Kultima, H., Norman, H.S., Aare, S., Radell, P., Eriksson, L.I., Hoffman, E.P., Larsson, L. Impaired autophagy, chaperone expression and protein synthesis in response to critical illness in porcine skeletal muscle.  Physiological Genomics.  2013. 45(12):477-86

Renaud,G., Llano-Diez, M., Gorza, L., Gustafson, A-M., Li, M., Hedström, Y., Ford, G. C. , Nair, K. S. , Perera, S. , Gautel, M., Jin,  J.P., Larsson L.. Sparing of muscle mass and function by passive loading in an experimental intensive care unit model  J Physiol. 2013 591(Pt 5):1385-402

Larsson, L. 2013.  Effects of Aging on Regulation of Muscle Contraction.  Basic, Aåpplied and Clinical Studies.  Invited lecture: “Stress and Ageing:  From Molecular Biology to Clinical Perspectives”.  September 6-8, Martin-Luther-University Halle-Wittenberg, Germany

 

Larsson, L. 2013.  Time-course analysis of mechanical ventilation-induced diaphragm muscle dysfunction.  European Muscle Conference, (oral presentation). Amsterdam, NL

 

Corpeno, R., Renaud, G., Llano-Diez, M, Larsson, L. 2013.  Sparing of muscle mass and function by passive loading in an experimental intensive care unit model. European Muscle Conference, Amsterdam, NL

 

Ogilvie, H., Cacciani, N., Larsson, L. 2013.  Combined effects of Controlled Mechanical Ventilation (CMV) and aging on rat diaphragm single muscle fibres. European Muscle Conference, Amsterdam, NL

 

Aqqad, H., Corpeno, R., Larsson, L. 2013.  Effects of the intensive care unit condition on craniofacial vs. limb muscle gene and protein expression.  European Muscle Conference, Amsterdam, NL

 

Llano-Diez, M., Renaud, G., Ochala, J., Gustafson, A.-M., Li, M., Corpeno, R., Aare, S., Qaisar, R., Hedström, Y., Dworkin, B., Nair, K.S., Ford, C, Pereira, S., Gautel, M., Larsson, L. 2013. “Mechanical silencing”.  A primary trigger of critical illness myopathy in nintensive care unit patients: experimental and clinical studies.  European Muscle Conference, Amsterdam, NL

 

Larsson, L. 2013.  Critical Illness Myopathy: Underlying mechanisms and intervention strategies.  In vited presentation.  Department of Biology. Texas AM, November 2013.

 

Larsson, L. 2013.  Experimental and Clinical Studies in Critical Illness Myopathy: Underlying mechanisms and intervention strategies.  In vited presentation.  Cancer research Center, Ohjio State University. November 2013.

 

Larsson, L.  2013.  Acute Quadriplegic Myopathy: Underlying Mechanisms and Specific Intervention Strategies.  Invited lecture Dept of Physiology, School of Medicine.  University of Kentucky. Lexington.

 

Larsson, L.  2013.  Experimental and Clinical Studies on Acute Quadriplegic Myopathy: Underlying Mechanisms, Improved Diagnostics and Specific Intervention Strategies.  Invited lecture Division of Pulmonary and Critical Care.  University of Iowa, Iowa City.

 

Li, M.,  Renaud, G.,  Artemenko, K., Bergquist, J., Larsson, L. 2013.  Myosin in aging skeletal muscle post-translational modifications and actomyosin interactions. SFRR meeting, Athens, Greece

 

Spanos, D., Li, M., Baron, C., Larsson, L. 2013.  The impact of oxidation on the motility of single muscle fibres expressing different myosin isoforms. SFRR meeting, Athens, Greece

 

•    dissemination activities to the general public

Larsson, L. 2013. HRT improves muscle function. (May 7 7.00 -7.57 PM).  US radioprogram: Super Human Radio. Triceptor Productions Studio Louisville KY

 

Name and Surname of the MC member : SASSON Shlomo

•    joint publications

Jaganjac M, Tirosh O, Cohen G, Sasson S, Zarkovic N.: Reactive aldehydes–second messengers of free radicals in diabetes mellitus. Free Radic Res. 2013 47 Suppl 1:39-48.

•    publications, talks, posters done/given with support of COST money

Sasson, S: Lipid peroxidation and protein modification in pancreatic β-cells in diabetes: the sweet road from hormesis to disaster. International Conference on Stress and Aging: From Molecular Biology to Clinical Perspectives. 5-7 September, 2013. Halle, Germany

 

Sasson, S.: Signaling and cytotoxic properties of lipid peroxidation by-products in pancreatic β-cells. Heinrich Heine University Faculty of Medicine and the German Diabetes Center, 19 September, 2013, Duesseldorf, Germany.

 

Sasson, S., Cohen, G.: Metabolic aging in diabetes: the glucolipotoxic connection. SFRR-Europe 2013 conference: The New Era of -omics in Free Radicals in Biology and Medicine. September 23-25, 2-13, Athens, Greece.

 

Sasson, S.: The role of lipoxygenases in inducing radical stress and lipid peroxidation in diabetes.

Annual Meeting of the Israeli Society for Oxygen and Free Radical Research. December 1, 2-13, Tel Hai, Israel

 

Name and Surname of the MC member : TORREGIANI Armida

publications, talks, posters done/given with support of COST money

Pub­li­ca­tions

Torreggiani A., Chatgilialoglu C., Ferreri C., Melchiorre M., Atrian S., Capdevila M. Non-enzymatic modifications in metallothioneins connected to lipid membrane damages: Structural and biomimetic studies under reductive radical stress. Journal of Proteomics  2013; 92: 204-215.

 

 

Name and Surname of the MC member : TROUGAKOS IP

 

•    joint publications

 

Trougakos IP, Sesti F, Tsakiri E, Gorgoulis VG. Non-enzymatic post-translational protein modifications and proteostasis network deregulation in carcinogenesis. J. Proteomics 2013 92, 274-298.

 

Trougakos IP. The Molecular Chaperone Apolipoprotein J/Clusterin as a Sensor of Oxidative Stress: Implications in Therapeutic Approaches – A Mini-Review. Gerontology 2013 59, 514-523.

 

Nedić O, Rattan SI, Grune T, Trougakos IP. Molecular effects of advanced glycation end products (AGEs) on cell signalling pathways, ageing and pathophysiology. Free Radic Res. 2013, 47 Suppl 1, 28-38.

 

 

•    publications, talks, posters done/given with support of COST money

 

Differential regulation of the proteasome and of antioxidant responses during aging in the somatic tissues and the gonads of Drosophila.

Tsakiri EN, Sykiotis GP, Papassideri IS, Terpos E, Dimopoulos MA, Gorgoulis VG, Bohmann D, Trougakos IP.

Abstracts of the SFRR – Europe 2013 Meeting (training School on “Model organisms to study ageing”), Athens, Greece 2012.

 

 

 

Name and Surname of the MC member: RUSKOVSKA Tatjana

•    publications, talks, posters done/given with support of COST money

1. Ruskovska T, Bernlohr DA. Oxidative stress and protein carbonylation in adipose tissue – Implications for insulin resistance and diabetes mellitus. J Proteomics. 2013 Oct 30;92:323-34.

2. Short Term Scientific Mission at Aston University, Birmingham, UK, 02 – 19 February 2013.

Faculty host: Prof. Helen Griffiths.

 

Name and Surname of the MC member : VINA Jose

•    publications, talks, posters done/given with support of COST money

Growth Hormone Replacement Therapy Prevents Sarcopenia by a Dual Mechanism: Improvement of Protein Balance and of Antioxidant Defenses.

Brioche T, Kireev RA, Cuesta S, Gratas-Delamarche A, Tresguerres JA, Gomez-Cabrera MC, Viña J. J Gerontol A Biol Sci Med Sci. 2013 Dec 3

 

Impact of exercise training on neuroplasticity-related growth factors in adolescents.

Pareja-Galeano H, Brioche T, Sanchis-Gomar F, Montal A, Jovaní C, Martínez-Costa C, Gomez-Cabrera MC, Viña J. J Musculoskelet Neuronal Interact. 2013 Sep;13(3):368-71.

 

FORUM ISSUE: “Free Radicals and Physical Exercise”.

Vina J, Gomez-Cabrera MC. Free Radic Res. 2014 Jan;48(1):1-2.

 

Pharmacological Properties of Physical Exercise in The Elderly.

Viña J, Borras C, Sanchis-Gomar F, Martinez-Bello VE, Olaso-Gonzalez G, Gambini J, Ingles M, Gomez-Cabrera MC. Curr Pharm Des. 2013 Sep 27.

 

Impact of exercise training on neuroplasticity-related growth factors in adolescents.

Pareja-Galeano H, Brioche T, Sanchis-Gomar F, Montal A, Jovaní C, Martínez-Costa C, Gomez-Cabrera MC, Viña J. J Musculoskelet Neuronal Interact. 2013 Sep;13(3):368-71.

 

The free radical theory of aging revisited: the cell signaling disruption theory of aging.

Viña J, Borras C, Abdelaziz KM, Garcia-Valles R, Gomez-Cabrera MC. Antioxid Redox Signal. 2013 Sep 10;19(8):779-87.

 

Reductive stress in young healthy individuals at risk of Alzheimer disease.

Badía MC, Giraldo E, Dasí F, Alonso D, Lainez JM, Lloret A, Viña J. Free Radic Biol Med. 2013 Oct;63:274-9.

 

Overweight, obesity, and all-cause mortality.

Viña J, Borras C, Gomez-Cabrera MC. JAMA. 2013 Apr 24;309(16):1679.

 

Effects of acute exercise and xanthine oxidase inhibition on novel cardiovascular biomarkers.

Sanchis-Gomar F, Bonaguri C, Aloe R, Pareja-Galeano H, Martinez-Bello V, Gomez-Cabrera MC, Candel J, Viña J, Lippi G. Transl Res. 2013 Aug;162(2):102-9.

 

Resveratrol: distribution, properties and perspectives.

Gambini J, López-Grueso R, Olaso-González G, Inglés M, Abdelazid K, El Alami M, Bonet-Costa V, Borrás C, Viña J. Rev Esp Geriatr Gerontol. 2013 Mar-Apr;48(2):79-88.

 

•    dissemination activities to the general public

SIMPOSIUM “BIOMARKERS OF EARLY ALZHEIMER’S DISEASE” 11th-12th March, 2013. Salón de Grados de la Facultad de Medicina. Blasco Ibáñez 13. Valencia