Catalysis, synthetic methodology and fine-chemistry processes
Identification of new organic, organometallic, and supported catalysts for the development of chemo- and stereoselective methods with a particular interest devoted to the discovery of new economically advantageous and environment-friendly processes (catalyst recovery and recycling; reactions in water or in aqueous medium; etc). New applications of the phase transfer catalysis to the synthesis of industrially relevant and biologically active products. Use of Ionic liquids as new reaction solvents of reduced environmental impact.
Computer-assisted investigation of the relationship between the origin of the stereoselection and the structure of the catalyst in asymmetric catalysis. Development of chiral ligands lacking rigid stereogenic elements and existing like configurationally stable residual enantiomers. Identification of new stereochemical descriptors for this unusual class of chiral compounds. Use of combinatorial techniques in the development of new catalysts applied to the synthesis of libraries of new chiral ligands for the optimization of new catalysts for industrially relevant enantioselective reactions. Synthesis and applications of new polymeric vinylpyrrolidones as soluble supports in organic synthesis. Application of organometallic and metallorganic reagents to stereoselective syntheses.
Researchers involved in these topics:
Rita Annunziata, Maurizio Benaglia, Franco Cozzi, Domenico Albanese, Clelia Giannini, Cesare Gennari, Giordano Lesma, Emanuela Licandro, Carlo Morelli, Fulvia Orsini, Laura Raimondi, Guido Sello, Alessandra Silvani, Giovanna Speranza