Luca Imeri

Curriculum vitae et studiorum

 

Luca Imeri M. D.

 

 

Associate Professor of Human Physiology

 

Department of Healt Sciences

University of Milan Medical School

San Paolo University Hospital (building C, floor 7, room 708)

Via A. Di Rudiní, 8

I-20142 Milan

Italy

 

phone  +39 02 503 23221

fax  +39 02 503 23220

luca.imeri@unimi.it

http://users.unimi.it/imeri/

 

Education

 

1979-1986                  M.D.

                                   University of Milan Medical School, Milan, Italy

 

 

Professional Positions

 

1987-1988                  Post-doctoral Fellow in Neurochemistry

"Mario Negri" Institute for Pharmacological  Research, Milan, Italy

 

1988-1994                  Research Associate

Institute of Human Physiology II, University of Milan Medical School, Milan, Italy

 

1991-1992                  Post-doctoral Research Associate

Department of Physiology and Biophysics, University of Tennessee, Memphis TN, USA

 

1994-2000                  Assistant Professor

Institute of Human Physiology II, University of Milan Medical School, Milan, Italy

 

1996-2000                  Adjunct Assistant Professor

Department of Psychiatry and Behavioral Sciences

                                    University of Texas Medical Branch, Galveston TX, USA

 

1997-1999                  Adjunct Assistant Professor

University of Florence School of Psychology, Florence, Italy

 

2001-present               Associate Professor of Human Physiology

2001-2010                  @ Institute of Human Physiology II

2011-present               @ Department of Medicine, Surgery & Dental Sciences, University of Milan Medical School, Milan, Italy

 

2001-2003                  Visiting Lecturer

2004-2010                  Adjunct Assistant Professor

Department of Anesthesiology, University of Michigan Medical School, Ann Arbor MI, USA

 

 

Honors & Awards

 

1984 & 1985               University of Milan “A. Taverna” Award

1992                            Italian Society for Neurological Research (ARIN) Award

1992                            Sleep Research Society (USA) Travel Award

1993                            World Federation of Sleep Research Societies Travel Award

2000-2004                  Treasurer and member of the Board of the Italian Sleep Research Society

2000                           “FY2000 JSPS Invitation Fellowship Program for Research in Japan”, Fellowship granted by the Japan Society for the Promotion of Science  to support a short program of research at Tokyo Medical and Dental University, Tokyo, Japan

2001-present               Member of the Scientific Board, and, from 2004, Director, University of Milan "Giuseppe Moruzzi" Center for Sleep Research

 

Teaching Responsabilities

 
 

1989-1999 Lecturer, Human Physiology Course, University of Milan Medical School, Milan, Italy, Neurophysiology
1992 -1997 Lecturer, Residency Program in Neurology and Residency Program in Neuropathology, University of Milan Medical School, Milan, Italy, Mechanisms of sleep regulation
1997-1999 Director and Lecturer, Anatomical and physiological basis of mental activity Course, University of Florence School of Psychology, Florence, Italy
1999-2003 Member of the scientific board, Ph.D. Program in Physiology of body compartments, University of Rome Tor Vergata and University of Milan
1999-2001 Director and Lecturer, Human and Oral Physiology, University of Milan Medical School and School of Dentistry, Milan, Italy
2000-2008 Lecturer, Residency Program in Neurology and Residency Program in Psychiatry, University of Milan Bicocca Medical School, Monza, Italy, Mechanisms of sleep regulation
2002-2009 Director, Morfology and Physiology Course, and Lecturer, Human and Oral Physiology Course, University of Milan Medical School and School of Dentistry, Milan, Italy
2001-present Member of the scientific board, Ph.D. Program in Physiology, University of Milan, Milan, Italy
2009-present Director and Lecturer, Human Physiology Course, University of Milan Medical School, Milan, Italy
2009-present Lecturer, Neurophysiology Course, Residency Program in Psychiatry, University of Milan Medical School, Italy,

 

Editorial Activities      

 

Sleep (IF 5.2), member of the Editorial Board

 

Reviewer for (last five years): Behavioral Brain Research; Brain, Behavior and Immunity; Epilepsia; Innate Immunity; International Journal of Biometeorology; Journal of Neuroscience Methods; Journal of Sleep Research; Nature Review Neuroscience; Neuropharmacology; Neuroscience; Neuroscience Letters; Physiology and Behavior; Psychoneuroendocrinology; Research in Veterinary Sciences; Sleep

 

 

Grant Support     

 

 

Agency

National Institute of Mental Health (NIMH), Bethesda MD, USA

Title

Cytokine and Neurotransmitter Interactions in Sleep Regulation

Period

2008-2013

Role                       

Co-Investigator

   

Agency

Italian Ministry for Education, University and Scientific Research

Title

The D178N/V129 mutation in familial Creutzfeldt-Jakob disease: sleep and vegetative alterations. A translational study

Period

2010-2012 

Role                       

Principal Investigator and national coordinator

 

 

 

+ intramural grants

 

Memberships         

                         

European Sleep Research Society

Italian Physiological Society

Italian Society for Sleep Research

Sleep Research Society (USA)

Society for Neuroscience (USA)

 

Biographical

 

Bithdate March 28, 1960
Birthplace Monza (Milan), Italy
Nationality Italian

 

 

Presented Papers & Invited Seminars (International only)    

 

            1990

10th Congress of the European Sleep Research Society, Strasbourg, France, May 20-25

 

            1994

12th Congress of the European Sleep Research Society, Firenze, May 22-27    

 

            1995

Legacy Research/Legacy Hospitals, Portland, OR, USA, March 8

 

World Federation of Sleep Research Societies 2nd International Congress, Nassau, The Bahamas, September 12-16

 

Psychiatric Clinical Research Center. Department of Psychiatry and Behavioral Sciences. The University of Texas Medical Branch, Galveston, Texas, USA, September 8

 

            1996

13th Congress of the European Sleep Research Society, Brussels, Belgium, June 16-21

 

1997

Department of Psychiatry and Behavioral Sciences. The University of Texas Medical Branch, Galveston, Texas, USA, August 29

 

3rd International Congress of the Polish Neuroscience Society, Lódz, Poland, September  7-10

 

            1998

Department of Pharmacology. The University of Texas Medical Branch, Galveston, Texas, USA, September 4.

 

14th Congress of the European Sleep Research Society, Madrid, Spain, September 9

 

1999

Department of Veterinary and Comparative Anatomy, Pharmacology, and Physiology. College of Veterinary Medicine. Washington State University, Pullman, Washington, USA, August 27

 

            2000

14th Annual Meeting of the Association of Professional Sleep Societies, Las Vegas, NE, USA, June 21.

15th Congress of the European Sleep Research Society, Istanbul, Turkey, September 14.

 

Department of Biocybernetics, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental Universities, Tokyo, Japan, July 25.

Department of Physiology, School of Medicine, Shimane Medical University, Izumo, Shimane, Japan, August 3.

Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Osaka, Japan, August 7;

Department of Physiology, Fukushima Medical University, Fukushima, Japan August 17.

 

2002

Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, Michigan, USA, September 4

 

Sleep Pathophysiology Conference, University of Patras, Patras, Greece, november  22

 

            2003

Department of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland, april 15

 

Sleep and Breathing, University of Patras, Patras, Greece, november  8

 

2005  

14th Annual Meeting of the Association of Professional Sleep Societies, Denver, CO, USA, June 23

 

            2007

Max Planck Institute of Psychiatry, Munich, Germany, september 25


 

           2008
Sleep 2008 – 22nd Annual Meeting of the Association of Professional Sleep Societies, Baltimore, MA, USA, june 12


 

19th Congress of the European Sleep Research Society, Glasgow, United Kingdom, September 13

 

           2009

12th Meeting of the Pneumologic Clinic, Univerity of Patras, Patras, Greece, march 27

 

Department of Neurology, Beth Israel and Deaconess Medical Center, Harvard Medical School, Boston, MA,USA, july 20

 

Gulbenkian Institute of Science (IGC), and Champalimaud Foundation, Lison, Portugal, december 11

 

           2011

Sleep Medicine Weekly Rounds, University of Washington School of Medicine & Harborview Medical Center, Seattle, WA, USA, February 15

 

 

 

April 2011

 

 


 

Publications(papers in Italian are not included)    

 

Articles in Peer-Reviewed Journals    

 

 

1)      Algeri, S., De Luigi, A., De Simoni, M. G., Imeri, L., Marconi, M., Nava, S., Perego, C., Sacchetti, G. (1988) Multiple and complex effects of buspirone on central dopaminergic system. Pharmacol. Biochem. Behav., 29:823-826. 

IF 1.5

 

2)      Imeri, L., Moneta, M. E., Mancia, M. (1988) Changes in spontaneous activity of medialis dorsalis thalamic neurones during sleep and wakefulness. Electroenceph. clin. Neurophysiol., 69:82-84.

IF 1.9

 

3)      Marini, G., Imeri, L., Mancia, M. (1988) Changes in sleep-waking cycle induced by lesions of medialis dorsalis thalamic nucleus in the cat. Neurosci. Lett., 85:223-227.                                    

IF 2.3

 

4)      De Simoni, M.G., De Luigi, A., Imeri, L., Algeri, S. (1990) Miniaturized optoelectronic system for telemetry of in vivo voltammetric signals. J. Neurosci. Meth., 33:233-240.  

IF 1.8

 

5)      De Simoni, M.G., Imeri, L., De Luigi, A., Fodritto, F., Garattini, S. (1990) Effect of buspirone and its metabolite 1-(2-pyrimydinyl)-piperazine on hippocampal serotoninergic system in freely moving rats. Life Sci., 46:197-205.             

IF 2.3

 

6)      Mancia, M., Imeri, L., Giglio, R. (1990) Modifications of cerebral electrical activity induced by the intracerebroventricular injection of acetyl-L-carnitine in cats. Int. J. Clin. Pharmacol. Res., X:115-121.

IF 0.3

 

7)      Imeri, L., Bianchi, S., Angeli, P., Mancia, M. (1991) Differential effects of M2 and M3 muscarinic antagonists on the sleep-wake cycle. NeuroReport, 2:383-385.                                                     

IF 2.6

 

8)      Imeri, L., Bianchi, S., Angeli, P., Mancia, M. (1992) M1 and M3 muscarinic receptors: specific roles in sleep regulation. NeuroReport, 3:276-278.       

IF 2.6

 

9)      Angeli, P., Imeri, L., Bianchi, Mancia, M. (1993) The influence of the muscarinic receptor subtypes on the sleep-wake cycle. Il Farmaco, 48:1197-1206.     

IF 0.4

 

10)    Hong, L., Imeri, L., Opp, M.R., Postlethwaite, A.E., Seyer, J.M., Krueger, J.M. (1993) Intercellular Adhesion Molecule-1 Expression Induced by IL-1ß or an IL-1ß Fragment is Blocked by an IL-1 Receptor Antagonist and a Soluble IL-1 Receptor. J. Neuroimmunol. , 44:163-170.

IF 3.7

 

11)    Imeri, L., Opp, M.R., Krueger, J.M. (1993) An IL-1 receptor and an IL-1 receptor antagonist attenuate muramyl dipeptide- and IL-1-ß induced sleep and fever. Am. J. Physiol., 265:R907-R913.

IF 3.2

 

12)    Imeri, L., Bianchi, S., Angeli, P., Mancia, M. (1994) Selective blockade of different brain stem muscarinic receptor subtypes: effects on the sleep-wake cycle. Brain Res., 636:68-72.

IF 2.7

 

13)    Imeri, L., De Simoni, M.G., Giglio, R., Clavenna, A., Mancia M. (1994) Changes in the serotonergic system during the sleep-wake cycle: simultaneous polygraphic and voltammetric recordings in hypothalamus using a telemetry system. Neuroscience,  58:353-358.

 IF 4.3

 

14)    De Simoni, M.G., Imeri, L., De Matteo, W., Perego, C., Simard, S., Terrazzino, S. (1995) Sleep regulation: interactions among cytokines and classical neurotransmitters. Advan. Neuroimmunol. , 5:189-200.                          

IF 1.1

 

15)    Imeri, L., Bianchi, S., Angeli, P., Mancia, M. (1995) Stimulation of cholinergic receptors in the Medial Preoptic Area affects sleep and cortical temperature. Am. J. Physiol. , 269:R294-R299.

IF 3.2

 

16)    Imeri, L., Bianchi, S., Angeli, P., Mancia, M. (1996) Muscarinic receptor subtypes in the Medial Preoptic Area and sleep-wake cycle. NeuroReport, 7: 417-420.

         IF 2.6

 

17)    Gemma, C., Imeri, L., De Simoni, M.G., Mancia, M. (1997) Interleukin-1 induces changes in sleep, brain temperature and serotonergic metabolism. Am. J. Physiol., 272:R601-606.

IF 3.2

 

18)    Imeri, L., Bianchi, S., Mancia, M. (1997) Muramyl dipeptide and IL-1 effects on sleep and brain temperature after inhibition of serotonin synthesis. Am. J. Physiol., 273:R1663-R1668.            

         IF 3.2

 

19)    De Simoni, M.G., Imeri, L. (1998) Cytokine-neurotransmitters interactions in the brain. Biol. Signals & Recept., 7:33-44.

 IF 2.2

 

20)    Gemma, C., Imeri, L., Mancia, M. (1999) Hippocampal type 1 (movement related) theta rhythm positively correlates with serotonergic activity. Arch. ital. Biol. , 137:151-160.  

IF 0.8

 

21)    Imeri, L., Gemma, C., De Simoni, M.G., Opp, M.R., Mancia, M. (1999) Hypothalamic serotonergic activity better correlates with brain temperature than with sleep-wake cycle and muscle tone in rats. Neuroscience, 89:1241-1246.

doi:10.1016/S0306-4522(98)00395-9;

IF 4.3

 

22)    Imeri, L., Mancia, M., Opp, M.R. (1999) Blockade of 5-HT2 receptors alters interleukin-1-induced changes in rat sleep. Neuroscience, 92: 745-749.           

doi:10.1016/S0306-4522(99)00006-8;

IF 4.3

 

23)    Opp, M.R., Imeri, L. (1999) Sleep as a behavioral model of neuro-immune interactions. Acta Neurobiol. Exper., 59 : 45-33.

IF 0.6

 

24)    Imeri, L. , Mancia, M., Bianchi, S., Opp, M.R. (2000) 5-hydroxytryptophan, but not L-tryptophan, alters sleep and brain temperature in rats. Neurosci., 95: 445-452.

         doi:10.1016/S0306-4522(99)00435-2;

         IF 4.3

 

25)    Opp, M.R. and Imeri, L. (2001) Rat strains that differ  in corticotropin-releasing hormone  production exhibit different sleep-wake responses to interleukin-1. Neuroendocrinology, 73:  272-284.                                                     

doi: 10.1159/000054644;

IF 3.2

 

26)    Gemma, C., Imeri, L., and Opp, M.R. (2003) Serotonergic activation stimulates the pituitary-adrenal axis and alters interleukin-1 (IL-1) mRNA expression in rat brain. Psychoneuroendocrinology , 28:   875-884.

doi:10.1016/S0306-4530(02)00103-8;

IF 3.0

 

27)    Manfridi, A., Brambilla,D., Bianchi,S., Mariotti, M., Opp,M.R. and Imeri, L. (2003) Interleukin-1b enhances non-rapid eye movement sleep when microinjected into the dorsal raphe nucleus and inhibits serotonergic neurons in vitro. Eur. J. Neurosci.,18: 1041-1049.

doi:10.1046/j.1460-9568.2003.02836.x;

IF 4.2

 

28)     Imeri, L., Ceccarelli, P., Mariotti, M., Manfridi,  Opp,M.R. and Mancia, M. (2004) Sleep, but not febrile responses of Fisher 344 rats to immune challenge are affected by aging. Brain Behav. Imm., 18: 399-404

doi:10.1016/j.bbi.2003.12.003;

IF 3.0

 

29)    Alam, N., McGinty, D., Bashir, T., Kumar, S. , Imeri, L., Opp, M.R., Szymusiak, R. (2004) Interleukin-1b modulates state-dependent discharge activity of Preoptic Area and Basal Forebrain Neurons: Role in Sleep Regulation. Eur. J. Neurosci., 20: 207-216.

doi:10.1111/j.1460-9568.2004.03469.x

IF 4.2

 

30)    Imeri, L. , Bianchi, S., Opp, M.R. (2005) Antagonism of corticotropin-releasing hormone alters  serotonergic-induced changes in brain temperature, but not sleep of rats. Am. J. Physiol., 289: R1116-1123.

doi:10.1152/ajpregu.00074.2005;

IF 3.4

 

31)    Imeri, L. , Bianchi, S., Opp, M.R. (2006) Inhibition of caspase-1 in rat brain reduces spontaneous non-rapid eye movement sleep and non-rapid eye movement sleep enhancement induced by lipopolysaccharide. Am. J. Physiol., 291: R197-204.

doi:10.1152/ajpregu.00828.2005;;

IF 3.4

 

32)    Brambilla, D., Franciosi, S., Opp, M.R., Imeri, L. (2007) Interleukin-1 inhibits firing of serotonergic neurons in the dorsal raphe nucleus and enhances GABAergic inhibitory post-synaptic potentials. Eur. J. Neurosci., 26: 1862-1869.           

          doi:10.1111/j.1460-9568.2007.05796.x;  

          IF 3.7

 

33)    Morrow, J.D., Vikraman, S., Imeri, L., Opp, M.R. (2008) Effects of serotonergic activation by 5-hydroxytryptophan on sleep and body temperature of C57BL/6J and interleukin-6-deficient mice are dose and time-related. Sleep, 31:21-33.                                                   

          IF 5.0

 

34)    *Dossena, S., *Imeri, L., Mangieri, M., Garofoli, A., Loris Ferrari1,3, Assunta Senatore, A., Restelli, E., Balducci, C., Fiordaliso, F., Salio, M., Susanna Bianchi, S., Fioriti, L., Morbin, M., Pincherle, A., Marcon, G., Villani, F., Mirjana Carli, M., Tagliavini, F., Forloni, G., Chiesa, R. (2008) Mutant Prion Protein Expression Causes Motor and Memory Deficits and Abnormal Sleep Patterns in a New Transgenic Mouse Model. Neuron, 60:1-12.

          doi:10.1016/j.neuron.2008.09.008;

          IF 13.4

          *these Authors contributed equally to this work

 

35)    Imeri, L., Opp, M.R. (2009) How (and why) the immune system makes us sleep. Nature Rev. Neurosci., 10: 199-210.

         doi:10.1038/nrn2576;

          IF 24.5

 

36)    Brambilla, D., Barajon, I., Bianchi, S., Opp, M.R., Imeri, L. (2010) Interleukin-1 inhibits putative cholinergic neurons in vitro and rapid eye movement sleep when microinjected into the rat laterodorsal tegmental nucleus. Sleep, 33:919-929.

          IF 5.4

 

Book Chapters     

 

1)      Mancia, M., Mariotti, M., Caraceni, A., Formenti, A., Imeri, L., Palestini, M. (1987) Center Median-Parafascicular thalamic complex and mediodorsal nucleus unitary responses to noxious stimuli and their conditioning by limbic and mesencephalic stimulations. In: Pain and motricity (Eccles, J.C., Tiengo, M., Cuello, D., Ottoson, A., Eds.). Raven Press, New York NY, USA, pp. 17-29.

 

2)      Marini, G., Imeri, L., Mancia, M. (1988) Medialis Dorsalis thalamic nucleus and the sleep-waking cycle:effect of bilateral lesions in chronic cats. In: Sleep in medical and neuropsychiatric disorders (Smirne, S., Franceschi, M., Ferini-Strambi, L., Eds.). Masson, Milano, pp. 193-195.

 

3)      De Simoni, M.G., Imeri, L., Giglio, R., Clavenna, A., Mancia M. (1990) Time-course of neurochemical changes in relation to the sleep-waking cycle in rat hypothalamic areas. In: The Diencephalon and Sleep (Mancia, M., Marini, G., Eds.). Raven Press, New York NY, USA, pp. 199-211.

 

4)      Imeri, L., De Simoni, M.G., Giglio, R.,Clavenna, A., Mancia, M. (1990) Hypothalamic somatostatin during the sleep-waking cycle. In: Sleep '90 (Horne, J., Ed.). Pontenagel Press, Bochum, Germany, pp. 106-108.

 

5)      De Simoni, M.G., Imeri, L., Giglio, R., Clavenna, A., Mancia M. (1992) Changes in the serotoninergic system during the sleep-wake cycle: simultaneous polygraphic and voltammetric recordings in the rat hypothalamus. In: Sleep, Hormones and Immunological System (Smirne, S., Franceschi, M., Ferini-Strambi, L., Zucconi, M., Eds.). Masson, Milano, pp. 99-109.

 

6)      Imeri, L., De Simoni, M.G. (1999) Immune alterations in neurotransmission. In: Handbook of Behavioral State Control. Cellular and Molecular Mechanisms (Lydic, R., Baghdoyan, H.A., Eds.). CRC Press, Boca Raton FL, USA, pp. 659-674. ISBN 0-8493-3151-X

 

7)      Opp, M.R., Imeri, L. (2011) Sleep disorders: basic science. In: Cancer symptoms science (Cleeland, C., Fisch, M., Dunn A., Eds.). Cambridge University Press, Cambridge, UK, pp. 170-178. ISBN 978-0-521-86901-0

 

 

Book Reviews    

 

1)      Imeri, L. (2007) Book review: Psychoanalysis and neuroscience (Mancia M., Ed – Springer, Milano, 2006), Int. J. Psychoanal., 88:1573-1577.               doi:10.1516/ijpa.2007.1555; IF 1.0

 

Other                     

 

1)     Imeri, L. (2007) Obituary. A tribute to Mauro Mancia. Sleep, 30:1596.

                          

 



 

April 2011