Luca Imeri M. D.
Associate Professor of Human Physiology
Department of Medicine, Surgery & Dental Sciences
University of Milan Medical School
San Paolo University Hospital (building C, floor 7, room 708)
Via A. Di Rudiní, 8
I-20142 Milan
Italy
phone +39 02 503 23221
fax +39 02 503 23220
http://users.unimi.it/imeri/
1979-1986 M.D.
University of Milan Medical School, Milan, Italy
1987-1988 Post-doctoral Fellow in Neurochemistry
"Mario Negri" Institute for Pharmacological Research, Milan, Italy
1988-1994 Research Associate
Institute of Human Physiology II, University of Milan Medical School, Milan, Italy
1991-1992 Post-doctoral Research Associate
Department of Physiology and Biophysics, University of Tennessee, Memphis TN, USA
1994-2000 Assistant Professor
Institute of Human Physiology II, University of Milan Medical School, Milan, Italy
1996-2000 Adjunct Assistant Professor
Department of Psychiatry and Behavioral Sciences
University of Texas Medical Branch, Galveston TX, USA
1997-1999 Adjunct Assistant Professor
University of Florence School of Psychology, Florence, Italy
2001-present Associate Professor of Human Physiology
2001-2010 @ Institute of Human Physiology II
2011-present @ Department of Medicine, Surgery & Dental Sciences, University of Milan Medical School, Milan, Italy
2001-2003 Visiting Lecturer
2004-2010 Adjunct Assistant Professor
Department of Anesthesiology, University of Michigan Medical School, Ann Arbor MI, USA
1984 & 1985 University of Milan “A. Taverna” Award
1992 Italian Society for Neurological Research (ARIN) Award
1992 Sleep Research Society (USA) Travel Award
1993 World Federation of Sleep Research Societies Travel Award
2000-2004 Treasurer and member of the Board of the Italian Sleep Research Society
2000 “FY2000 JSPS Invitation Fellowship Program for Research in Japan”, Fellowship granted by the Japan Society for the Promotion of Science to support a short program of research at Tokyo Medical and Dental University, Tokyo, Japan
2001-present Member of the Scientific Board, and, from 2004, Director, University of Milan "Giuseppe Moruzzi" Center for Sleep Research
| 1989-1999 | Lecturer, Human Physiology Course, University of Milan Medical School, Milan, Italy, Neurophysiology |
| 1992 -1997 | Lecturer, Residency Program in Neurology and Residency Program in Neuropathology, University of Milan Medical School, Milan, Italy, Mechanisms of sleep regulation |
| 1997-1999 | Director and Lecturer, Anatomical and physiological basis of mental activity Course, University of Florence School of Psychology, Florence, Italy |
| 1999-2003 | Member of the scientific board, Ph.D. Program in Physiology of body compartments, University of Rome Tor Vergata and University of Milan |
| 1999-2001 | Director and Lecturer, Human and Oral Physiology, University of Milan Medical School and School of Dentistry, Milan, Italy |
| 2000-2008 | Lecturer, Residency Program in Neurology and Residency Program in Psychiatry, University of Milan Bicocca Medical School, Monza, Italy, Mechanisms of sleep regulation |
| 2002-2009 | Director, Morfology and Physiology Course, and Lecturer, Human and Oral Physiology Course, University of Milan Medical School and School of Dentistry, Milan, Italy |
| 2001-present | Member of the scientific board, Ph.D. Program in Physiology, University of Milan, Milan, Italy |
| 2009-present | Director and Lecturer, Human Physiology Course, University of Milan Medical School, Milan, Italy |
| 2009-present | Lecturer, Neurophysiology Course, Residency Program in Psychiatry, University of Milan Medical School, Italy, |
Sleep (IF 5.2), member of the Editorial Board
Reviewer for (last five years): Behavioral Brain Research; Brain, Behavior and Immunity; Epilepsia; Innate Immunity; International Journal of Biometeorology; Journal of Neuroscience Methods; Journal of Sleep Research; Nature Review Neuroscience; Neuropharmacology; Neuroscience; Neuroscience Letters; Physiology and Behavior; Psychoneuroendocrinology; Research in Veterinary Sciences; Sleep
|
Agency |
National Institute of Mental Health (NIMH), Bethesda MD, USA |
|
Title |
Cytokine and Neurotransmitter Interactions in Sleep Regulation |
|
Period |
2008-2013 |
|
Role |
Co-Investigator |
|
Agency |
Italian Ministry for Education, University and Scientific Research |
|
Title |
The D178N/V129 mutation in familial Creutzfeldt-Jakob disease: sleep and vegetative alterations. A translational study |
|
Period |
2010-2012 |
|
Role |
Principal Investigator and national coordinator |
+ intramural grants
European Sleep Research Society
Italian Physiological Society
Italian Society for Sleep Research
Sleep Research Society (USA)
Society for Neuroscience (USA)
| Bithdate | March 28, 1960 |
| Birthplace | Monza (Milan), Italy |
| Nationality | Italian |
Presented Papers & Invited Seminars (International only)
1990
10th Congress of the European Sleep Research Society, Strasbourg, France, May 20-25
1994
12th Congress of the European Sleep Research Society, Firenze, May 22-27
1995
Legacy Research/Legacy Hospitals, Portland, OR, USA, March 8
World Federation of Sleep Research Societies 2nd International Congress, Nassau, The Bahamas, September 12-16
Psychiatric Clinical Research Center. Department of Psychiatry and Behavioral Sciences. The University of Texas Medical Branch, Galveston, Texas, USA, September 8
1996
13th Congress of the European Sleep Research Society, Brussels, Belgium, June 16-21
1997
Department of Psychiatry and Behavioral Sciences. The University of Texas Medical Branch, Galveston, Texas, USA, August 29
3rd International Congress of the Polish Neuroscience Society, Lódz, Poland, September 7-10
1998
Department of Pharmacology. The University of Texas Medical Branch, Galveston, Texas, USA, September 4.
14th Congress of the European Sleep Research Society, Madrid, Spain, September 9
1999
Department of Veterinary and Comparative Anatomy, Pharmacology, and Physiology. College of Veterinary Medicine. Washington State University, Pullman, Washington, USA, August 27
2000
14th Annual Meeting of the Association of Professional Sleep Societies, Las Vegas, NE, USA, June 21.
15th Congress of the European Sleep Research Society, Istanbul, Turkey, September 14.
Department of Biocybernetics, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental Universities, Tokyo, Japan, July 25.
Department of Physiology, School of Medicine, Shimane Medical University, Izumo, Shimane, Japan, August 3.
Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Osaka, Japan, August 7;
Department of Physiology, Fukushima Medical University, Fukushima, Japan August 17.
2002
Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, Michigan, USA, September 4
Sleep Pathophysiology Conference, University of Patras, Patras, Greece, november 22
2003
Department of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland, april 15
Sleep and Breathing, University of Patras, Patras, Greece, november 8
2005
14th Annual Meeting of the Association of Professional Sleep Societies, Denver, CO, USA, June 23
2007
Max Planck Institute of Psychiatry, Munich, Germany, september 25
2008
Sleep 2008 – 22nd Annual Meeting of the Association of Professional Sleep
Societies, Baltimore, MA, USA, june 12
19th Congress of the European Sleep Research Society, Glasgow, United Kingdom, September 13
2009
12th Meeting of the Pneumologic Clinic, Univerity of Patras, Patras, Greece, march 27
Department of Neurology, Beth Israel and Deaconess Medical Center, Harvard Medical School, Boston, MA,USA, july 20
Gulbenkian Institute of Science (IGC), and Champalimaud Foundation, Lison, Portugal, december 11
2011
Sleep Medicine Weekly Rounds, University of Washington School of Medicine & Harborview Medical Center, Seattle, WA, USA, February 15
April 2011
Publications(papers in Italian are not included)
Articles in Peer-Reviewed Journals
1) Algeri, S., De Luigi, A., De Simoni, M. G., Imeri, L., Marconi, M., Nava, S., Perego, C., Sacchetti, G. (1988) Multiple and complex effects of buspirone on central dopaminergic system. Pharmacol. Biochem. Behav., 29:823-826.
IF 1.5
2) Imeri, L., Moneta, M. E., Mancia, M. (1988) Changes in spontaneous activity of medialis dorsalis thalamic neurones during sleep and wakefulness. Electroenceph. clin. Neurophysiol., 69:82-84.
IF 1.9
3) Marini, G., Imeri, L., Mancia, M. (1988) Changes in sleep-waking cycle induced by lesions of medialis dorsalis thalamic nucleus in the cat. Neurosci. Lett., 85:223-227.
IF 2.3
4) De Simoni, M.G., De Luigi, A., Imeri, L., Algeri, S. (1990) Miniaturized optoelectronic system for telemetry of in vivo voltammetric signals. J. Neurosci. Meth., 33:233-240.
IF 1.8
5) De Simoni, M.G., Imeri, L., De Luigi, A., Fodritto, F., Garattini, S. (1990) Effect of buspirone and its metabolite 1-(2-pyrimydinyl)-piperazine on hippocampal serotoninergic system in freely moving rats. Life Sci., 46:197-205.
IF 2.3
6) Mancia, M., Imeri, L., Giglio, R. (1990) Modifications of cerebral electrical activity induced by the intracerebroventricular injection of acetyl-L-carnitine in cats. Int. J. Clin. Pharmacol. Res., X:115-121.
IF 0.3
7) Imeri, L., Bianchi, S., Angeli, P., Mancia, M. (1991) Differential effects of M2 and M3 muscarinic antagonists on the sleep-wake cycle. NeuroReport, 2:383-385.
IF 2.6
8) Imeri, L., Bianchi, S., Angeli, P., Mancia, M. (1992) M1 and M3 muscarinic receptors: specific roles in sleep regulation. NeuroReport, 3:276-278.
IF 2.6
9) Angeli, P., Imeri, L., Bianchi, Mancia, M. (1993) The influence of the muscarinic receptor subtypes on the sleep-wake cycle. Il Farmaco, 48:1197-1206.
IF 0.4
10) Hong, L., Imeri, L., Opp, M.R., Postlethwaite, A.E., Seyer, J.M., Krueger, J.M. (1993) Intercellular Adhesion Molecule-1 Expression Induced by IL-1ß or an IL-1ß Fragment is Blocked by an IL-1 Receptor Antagonist and a Soluble IL-1 Receptor. J. Neuroimmunol. , 44:163-170.
IF 3.7
11) Imeri, L., Opp, M.R., Krueger, J.M. (1993) An IL-1 receptor and an IL-1 receptor antagonist attenuate muramyl dipeptide- and IL-1-ß induced sleep and fever. Am. J. Physiol., 265:R907-R913.
IF 3.2
12) Imeri, L., Bianchi, S., Angeli, P., Mancia, M. (1994) Selective blockade of different brain stem muscarinic receptor subtypes: effects on the sleep-wake cycle. Brain Res., 636:68-72.
IF 2.7
13) Imeri, L., De Simoni, M.G., Giglio, R., Clavenna, A., Mancia M. (1994) Changes in the serotonergic system during the sleep-wake cycle: simultaneous polygraphic and voltammetric recordings in hypothalamus using a telemetry system. Neuroscience, 58:353-358.
IF 4.3
14) De Simoni, M.G., Imeri, L., De Matteo, W., Perego, C., Simard, S., Terrazzino, S. (1995) Sleep regulation: interactions among cytokines and classical neurotransmitters. Advan. Neuroimmunol. , 5:189-200.
IF 1.1
15) Imeri, L., Bianchi, S., Angeli, P., Mancia, M. (1995) Stimulation of cholinergic receptors in the Medial Preoptic Area affects sleep and cortical temperature. Am. J. Physiol. , 269:R294-R299.
IF 3.2
16) Imeri, L., Bianchi, S., Angeli, P., Mancia, M. (1996) Muscarinic receptor subtypes in the Medial Preoptic Area and sleep-wake cycle. NeuroReport, 7: 417-420.
IF 2.6
17) Gemma, C., Imeri, L., De Simoni, M.G., Mancia, M. (1997) Interleukin-1 induces changes in sleep, brain temperature and serotonergic metabolism. Am. J. Physiol., 272:R601-606.
IF 3.2
18) Imeri, L., Bianchi, S., Mancia, M. (1997) Muramyl dipeptide and IL-1 effects on sleep and brain temperature after inhibition of serotonin synthesis. Am. J. Physiol., 273:R1663-R1668.
IF 3.2
19) De Simoni, M.G., Imeri, L. (1998) Cytokine-neurotransmitters interactions in the brain. Biol. Signals & Recept., 7:33-44.
IF 2.2
20) Gemma, C., Imeri, L., Mancia, M. (1999) Hippocampal type 1 (movement related) theta rhythm positively correlates with serotonergic activity. Arch. ital. Biol. , 137:151-160.
IF 0.8
21) Imeri, L., Gemma, C., De Simoni, M.G., Opp, M.R., Mancia, M. (1999) Hypothalamic serotonergic activity better correlates with brain temperature than with sleep-wake cycle and muscle tone in rats. Neuroscience, 89:1241-1246.
doi:10.1016/S0306-4522(98)00395-9;
IF 4.3
22) Imeri, L., Mancia, M., Opp, M.R. (1999) Blockade of 5-HT2 receptors alters interleukin-1-induced changes in rat sleep. Neuroscience, 92: 745-749.
doi:10.1016/S0306-4522(99)00006-8;
IF 4.3
23) Opp, M.R., Imeri, L. (1999) Sleep as a behavioral model of neuro-immune interactions. Acta Neurobiol. Exper., 59 : 45-33.
IF 0.6
24) Imeri, L. , Mancia, M., Bianchi, S., Opp, M.R. (2000) 5-hydroxytryptophan, but not L-tryptophan, alters sleep and brain temperature in rats. Neurosci., 95: 445-452.
doi:10.1016/S0306-4522(99)00435-2;
IF 4.3
25) Opp, M.R. and Imeri, L. (2001) Rat strains that differ in corticotropin-releasing hormone production exhibit different sleep-wake responses to interleukin-1. Neuroendocrinology, 73: 272-284.
doi: 10.1159/000054644;
IF 3.2
26) Gemma, C., Imeri, L., and Opp, M.R. (2003) Serotonergic activation stimulates the pituitary-adrenal axis and alters interleukin-1 (IL-1) mRNA expression in rat brain. Psychoneuroendocrinology , 28: 875-884.
doi:10.1016/S0306-4530(02)00103-8;
IF 3.0
27) Manfridi, A., Brambilla,D., Bianchi,S., Mariotti, M., Opp,M.R. and Imeri, L. (2003) Interleukin-1b enhances non-rapid eye movement sleep when microinjected into the dorsal raphe nucleus and inhibits serotonergic neurons in vitro. Eur. J. Neurosci.,18: 1041-1049.
doi:10.1046/j.1460-9568.2003.02836.x;
IF 4.2
28) Imeri, L., Ceccarelli, P., Mariotti, M., Manfridi, Opp,M.R. and Mancia, M. (2004) Sleep, but not febrile responses of Fisher 344 rats to immune challenge are affected by aging. Brain Behav. Imm., 18: 399-404
doi:10.1016/j.bbi.2003.12.003;
IF 3.0
29) Alam, N., McGinty, D., Bashir, T., Kumar, S. , Imeri, L., Opp, M.R., Szymusiak, R. (2004) Interleukin-1b modulates state-dependent discharge activity of Preoptic Area and Basal Forebrain Neurons: Role in Sleep Regulation. Eur. J. Neurosci., 20: 207-216.
doi:10.1111/j.1460-9568.2004.03469.x
IF 4.2
30) Imeri, L. , Bianchi, S., Opp, M.R. (2005) Antagonism of corticotropin-releasing hormone alters serotonergic-induced changes in brain temperature, but not sleep of rats. Am. J. Physiol., 289: R1116-1123.
doi:10.1152/ajpregu.00074.2005;
IF 3.4
31) Imeri, L. , Bianchi, S., Opp, M.R. (2006) Inhibition of caspase-1 in rat brain reduces spontaneous non-rapid eye movement sleep and non-rapid eye movement sleep enhancement induced by lipopolysaccharide. Am. J. Physiol., 291: R197-204.
doi:10.1152/ajpregu.00828.2005;;
IF 3.4
32) Brambilla, D., Franciosi, S., Opp, M.R., Imeri, L. (2007) Interleukin-1 inhibits firing of serotonergic neurons in the dorsal raphe nucleus and enhances GABAergic inhibitory post-synaptic potentials. Eur. J. Neurosci., 26: 1862-1869.
doi:10.1111/j.1460-9568.2007.05796.x;
IF 3.7
33) Morrow, J.D., Vikraman, S., Imeri, L., Opp, M.R. (2008) Effects of serotonergic activation by 5-hydroxytryptophan on sleep and body temperature of C57BL/6J and interleukin-6-deficient mice are dose and time-related. Sleep, 31:21-33.
IF 5.0
34) *Dossena, S., *Imeri, L., Mangieri, M., Garofoli, A., Loris Ferrari1,3, Assunta Senatore, A., Restelli, E., Balducci, C., Fiordaliso, F., Salio, M., Susanna Bianchi, S., Fioriti, L., Morbin, M., Pincherle, A., Marcon, G., Villani, F., Mirjana Carli, M., Tagliavini, F., Forloni, G., Chiesa, R. (2008) Mutant Prion Protein Expression Causes Motor and Memory Deficits and Abnormal Sleep Patterns in a New Transgenic Mouse Model. Neuron, 60:1-12.
doi:10.1016/j.neuron.2008.09.008;
IF 13.4
*these Authors contributed equally to this work
35) Imeri, L., Opp, M.R. (2009) How (and why) the immune system makes us sleep. Nature Rev. Neurosci., 10: 199-210.
doi:10.1038/nrn2576;
IF 24.5
36) Brambilla, D., Barajon, I., Bianchi, S., Opp, M.R., Imeri, L. (2010) Interleukin-1 inhibits putative cholinergic neurons in vitro and rapid eye movement sleep when microinjected into the rat laterodorsal tegmental nucleus. Sleep, 33:919-929.
IF 5.4
1) Mancia, M., Mariotti, M., Caraceni, A., Formenti, A., Imeri, L., Palestini, M. (1987) Center Median-Parafascicular thalamic complex and mediodorsal nucleus unitary responses to noxious stimuli and their conditioning by limbic and mesencephalic stimulations. In: Pain and motricity (Eccles, J.C., Tiengo, M., Cuello, D., Ottoson, A., Eds.). Raven Press, New York NY, USA, pp. 17-29.
2) Marini, G., Imeri, L., Mancia, M. (1988) Medialis Dorsalis thalamic nucleus and the sleep-waking cycle:effect of bilateral lesions in chronic cats. In: Sleep in medical and neuropsychiatric disorders (Smirne, S., Franceschi, M., Ferini-Strambi, L., Eds.). Masson, Milano, pp. 193-195.
3) De Simoni, M.G., Imeri, L., Giglio, R., Clavenna, A., Mancia M. (1990) Time-course of neurochemical changes in relation to the sleep-waking cycle in rat hypothalamic areas. In: The Diencephalon and Sleep (Mancia, M., Marini, G., Eds.). Raven Press, New York NY, USA, pp. 199-211.
4) Imeri, L., De Simoni, M.G., Giglio, R.,Clavenna, A., Mancia, M. (1990) Hypothalamic somatostatin during the sleep-waking cycle. In: Sleep '90 (Horne, J., Ed.). Pontenagel Press, Bochum, Germany, pp. 106-108.
5) De Simoni, M.G., Imeri, L., Giglio, R., Clavenna, A., Mancia M. (1992) Changes in the serotoninergic system during the sleep-wake cycle: simultaneous polygraphic and voltammetric recordings in the rat hypothalamus. In: Sleep, Hormones and Immunological System (Smirne, S., Franceschi, M., Ferini-Strambi, L., Zucconi, M., Eds.). Masson, Milano, pp. 99-109.
6) Imeri, L., De Simoni, M.G. (1999) Immune alterations in neurotransmission. In: Handbook of Behavioral State Control. Cellular and Molecular Mechanisms (Lydic, R., Baghdoyan, H.A., Eds.). CRC Press, Boca Raton FL, USA, pp. 659-674. ISBN 0-8493-3151-X
7) Opp, M.R., Imeri, L. (2011) Sleep disorders: basic science. In: Cancer symptoms science (Cleeland, C., Fisch, M., Dunn A., Eds.). Cambridge University Press, Cambridge, UK, pp. 170-178. ISBN 978-0-521-86901-0
1) Imeri, L. (2007) Book review: Psychoanalysis and neuroscience (Mancia M., Ed – Springer, Milano, 2006), Int. J. Psychoanal., 88:1573-1577. doi:10.1516/ijpa.2007.1555; IF 1.0
1) Imeri, L. (2007) Obituary. A tribute to Mauro Mancia. Sleep, 30:1596.
April 2011