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NEURALSTEM and NEUROGENE LAB

NEURALSTEM LAB

 

STEFANIA CORTI

POSITION TITLE:

  • Assistant Professor of Neurology (MED-26), Faculty of Medicine, University of Milan.
  • Clinical Assistant Neurologist, Neurology Unit, Foundation I.R.C.C.S. “Ca’Granda” Maggiore Hospital.
Stefania Corti
INSTITUTION AND LOCATION DEGREE YEAR(s) FIELD OF STUDY
University of Milan M.D. degree with Honors 1997 Medicine
University of Milan Board Certified Neurology 1998-2003 Neurology
University of Milan Ph.D. 2003-2006 Molecular Medicine
POSITIONS AND EMPLOYMENT
HONORS AND AWARDS
  • 1998: “De Visart Award” for research in neurological diseases.
  • 2008: World Muscle Society Award Young Investigator Prize.
  • She is member of Scientific Council of “Dino Ferrari Center” for the study and therapy of neuromuscular and neurodegenerative diseases, University of Milan.
CLINICAL ACTIVITY
  • 1994-1997 Internship as student, then as MD at the Institute of Clinical Neurology of the University of Milan. In these years she frequented the in- and out-patient Clinics
  • 1998 Professional habilitation and Registration at the Medical Board in Milano
  • 1998-2003 Residency in Neurology Department of Neurological Sciences, University of Milan.
  • 2003-2006 She frequented the in- and out-patient clinics as neurologist at the Department of Neurological Sciences, University of Milan. She regularly attended to the out-patient clinics of the Centro Dino Ferrari for neuromuscular disorders
  • Since October 2006 Assistant Neurologist, Neurology Unit, IRCCS Foundation “Ca’ Granda”, Maggiore Hospital. Since then she performs clinical in patient, out patient activity, emergency activity as consultant neurologist. She regularly attends to the out-patient clinics of the Centro Dino Ferrari for neuromuscular disorders and the Motor Neuron Diseases out-patient service.
RESEARCH ACTIVITY
Since 2006 she is Principal Investigator Neural Stem Cell Lab. The principal research subjects are:
  • Molecular Mechanisms of Motor Neuron Diseases
  • Study of cell-mediated therapeutic strategies for motor neuron diseases
  • Molecular mechanisms of pluripotency and neuronal and motoneuronal differentiation
  • Gene therapy approaches as a therapy for neurodegenerative and neuromuscular diseases.
  • Molecular mechanisms of neurodegenerative diseases
  • Molecular mechanisms of mitochondrial diseases
  • Molecular mechanisms of mitochondrial diseases
  • Biomolecular analysis of ethiopathogenesis of muscular diseases (Muscular Dystrophies and Myopathies)
LABORATORY ACTIVITY
Since October 2006 she coordinates the molecular diagnostic activity (biochemistry and genetics) of the Biochemistry, Genetic and Cell Laboratory (Director Prof. G.P. Comi of the Department of Neurological Sciences. These diagnostic molecular analyses include: gene sequences of known gene of Amyotrophic Lateral Sclerosis (ALS) (ALS1, ALS6, ALS8, ALS9, ALS10, DCTN1, MAPT1), gene analyses of other motor neuron diseases (SMA, SMARD1, DSMAV) and hereditary neuropathies (CMT2A2, CMT2D, CMT2B1, CMT4A), molecular analyses for some neurodegenerative diseases (prion diseases, frontotemporal dementia (VCP, PGRN, CHMP2B, MAPT), Parkinson disease (PARK1, PARK2, PARK6, PARK7, PARK8), molecular analyses for dystrophinopaties (DMD/BMD) including Multiplex PCR and gene sequencing, gene sequences of some known gene of Limb Girdle Muscular Dystrophies (LGMD 1A, 1B, 1C and LGMD2 A to G, 2I, 2K, 2M), Myotonic Dystrophies (DM1 e DM2) e muscular channellopathies, metabolic myopathies (lipid and glycogen disorders). Indeed we perform molecular analyses for mitochondrial diseases both linked to mtDNA mutations and to nuclear genes (PEO A1-A4 and mtDNA depletion syndromes). The diagnostic activity includes the biochemical analysis of glucidic, lipid and mitochondrial metabolism and the proteic analysis of several proteins involved in neuromuscular diseases.
TEACHING/EDUCATION
  • School of Medicine

    Frontal lessons and tutorial activity in the Neurology course Faculty of Medicine, University of Milan, (groups C- D-H): academic years: 2006-2007, 2007-2008, 2008-2009. Unified Group: 2009-2010, 2010-2011
  • School of Biotechnology

    Frontal lessons in the Diagnostic Biotechnology (C2), Biotechnology and Molecular Medicine, Faculty of Medicine, University of Milan, academic years: 2006-2007, 2007-2008, 2008-2009, 2009-2010, 2010-2011
  • School of Nurse

    Chair of Neurology, in School of Nurse, Faculty of Medicine, University of Milan, academic years: 2006-2007, 2007-2008, 2008-2009, 2009-2010, 2010-2011
  • Neurology Residency

    Frontal lessons of Pediatric Neurology Course, Neurology Resident School, University of Milan, academic years: 2006-2007, 2007-2008, 2008-2009, 2009-2010, 2010-2011
  • Thesis Supervisor

    • Co-supervisor of 7 theses of students in School of Medicine
    • Co-supervisor of 2 theses of students in School of Biotechnology
    • Co-supervisor of 2 theses of students in School of Nurse
  • Tutoring

    • Tutor of students in PhD of Molecular Medicine (years XXII, XXIV, XXV)
    • Tutor of students in School of Medicine
    • Tutor of Neurology residents.
SELECTED PEER-REVIEWED PUBLICATIONS (Chronological order) Last 3 years
  • Human motor neuron generation from embryonic stem cells and induced pluripotent stem cells. Cell Mol Life Sci. 2010 Jul 29.

    Nizzardo M, Simone C, Falcone M, Locatelli F, Riboldi G, Comi GP, Corti S.
  • Systemic transplantation of c-kit+ cells exerts a therapeutic effect in a model of amyotrophic lateral sclerosis. Hum Mol Genet. 2010 Oct 1;19(19):3782-96.

    Corti S, Nizzardo M, Nardini M, Donadoni C, Salani S, Simone C, Falcone M, Riboldi G, Govoni A, Bresolin N, Comi GP.
  • Mitochondrial respiratory chain dysfunction in muscle from patients with amyotrophic lateral sclerosis. Arch Neurol. 2010 Jul;67(7):849-54.

    Crugnola V, Lamperti C, Lucchini V, Ronchi D, Peverelli L, Prelle A, Sciacco M, Bordoni A, Fassone E, Fortunato F, Corti S, Silani V, Bresolin N, Di Mauro S, Comi GP, Moggio M.
  • The m.12316G>A mutation in the mitochondrial tRNA Leu(CUN) gene is associated with mitochondrial myopathy and respiratory impairment. J Neurol Sci. 2010 May 15;292(1-2):107-10. Epub 2010 Feb 18.

    Ronchi D, Virgilio R, Bordoni A, Fassone E, Sciacco M, Ciscato P, Moggio M, Govoni A, Corti S, Bresolin N, Comi GP.
  • Embryonic stem cell-derived neural stem cells improve spinal muscular atrophy phenotype in mice. Brain. 2010 Feb;133(Pt 2):465-81.

    Corti S, Nizzardo M, Nardini M, Donadoni C, Salani S, Ronchi D, Simone C, Falcone M, Papadimitriou D, Locatelli F, Mezzina N, Gianni F, Bresolin N, Comi GP.
  • Motoneuron transplantation rescues the phenotype of SMARD1 (spinal muscular atrophy with respiratory distress type 1). J Neurosci. 2009 Sep 23;29(38):11761-71.

    Corti S, Nizzardo M, Nardini M, Donadoni C, Salani S, Del Bo R, Papadimitriou D, Locatelli F, Mezzina N, Gianni F, Bresolin N, Comi GP.
  • Association study between XRCC1 gene polymorphisms and sporadic amyotrophic lateral sclerosis. Amyotroph Lateral Scler. 2010;11(1-2):122-4.

    Coppedè F, Migheli F, Lo Gerfo A, Fabbrizi MR, Carlesi C, Mancuso M, Corti S, Mezzina N, del Bo R, Comi GP, Siciliano G, Migliore L.
  • No major progranulin genetic variability contribution to disease etiopathogenesis in an ALS Italian cohort. Neurobiol Aging. 2009 Jul 24.

    Del Bo R, Corti S, Santoro D, Ghione I, Fenoglio C, Ghezzi S, Ranieri M, Galimberti D, Mancuso M, Siciliano G, Briani C, Murri L, Scarpini E, Schymick JC, Traynor BJ, Bresolin N, Comi GP.
  • Clinical studies in stem cells transplantation for stroke: a review. Curr Vasc Pharmacol. 2010 Jan;8(1):29-34.

    Bersano A, Ballabio E, Lanfranconi S, Boncoraglio GB, Corti S, Locatelli F, Baron P, Bresolin N, Parati E, Candelise L.
  • The mitochondrial disulfide relay system protein GFER is mutated in autosomal-recessive myopathy with cataract and combined respiratory-chain deficiency. Am J Hum Genet. 2009 May;84(5):594-604.

    Di Fonzo A, Ronchi D, Lodi T, Fassone E, Tigano M, Lamperti C, Corti S, Bordoni A, Fortunato F, Nizzardo M, Napoli L, Donadoni C, Salani S, Saladino F, Moggio M, Bresolin N, Ferrero I, Comi GP.
  • TARDBP (TDP-43) sequence analysis in patients with familial and sporadic ALS: identification of two novel mutations. Eur J Neurol. 2009 Jun;16(6):727-32.

    Del Bo R, Ghezzi S, Corti S, Pandolfo M, Ranieri M, Santoro D, Ghione I, Prelle A, Orsetti V, Mancuso M, Sorarù G, Briani C, Angelini C, Siciliano G, Bresolin N, Comi GP.
  • Amyotrophic lateral sclerosis linked to a novel SOD1 mutation with muscle mitochondrial dysfunction. J Neurol Sci. 2009 Jan 15;276(1-2):170-4. Epub 2008

    Corti S, Donadoni C, Ronchi D, Bordoni A, Fortunato F, Santoro D, Del Bo R, Lucchini V, Crugnola V, Papadimitriou D, Salani S, Moggio M, Bresolin N, Comi GP.
  • Stem cell therapy in stroke. Cell Mol Life Sci. 2009 Mar;66(5):757-72.

    Locatelli F, Bersano A, Ballabio E, Lanfranconi S, Papadimitriou D, Strazzer S, Bresolin N, Comi GP, Corti S.
  • Mutated mitofusin 2 presents with intrafamilial variability and brain mitochondrial dysfunction. Neurology. 2008 Dec 9;71(24):1959-66.

    Del Bo R, Moggio M, Rango M, Bonato S, D'Angelo MG, Ghezzi S, Airoldi G, Bassi MT, Guglieri M, Napoli L, Lamperti C, Corti S, Federico A, Bresolin N, Comi GP.
  • DPP6 gene variability confers increased risk of developing sporadic amyotrophic lateral sclerosis in Italian patients. J Neurol Neurosurg Psychiatry. 2008 Sep;79(9):1085.

    Del Bo R, Ghezzi S, Corti S, Santoro D, Prelle A, Mancuso M, Siciliano G, Briani C, Murri L, Bresolin N, Comi GP.
  • Inclusion body myopathy and frontotemporal dementia caused by a novel VCP mutation. Neurobiol Aging. 2009 May;30(5):752-8.

    Bersano A, Del Bo R, Lamperti C, Ghezzi S, Fagiolari G, Fortunato F, Ballabio E, Moggio M, Candelise L, Galimberti D, Virgilio R, Lanfranconi S, Torrente Y, Carpo M, Bresolin N, Comi GP, Corti S.
  • Is erythropoietin gene a modifier factor in amyotrophic lateral sclerosis? Neurobiol Aging. 2009 May;30(5):842-4

    Ghezzi S, Del Bo R, Scarlato M, Nardini M, Carlesi C, Prelle A, Corti S, Mancuso M, Briani C, Siciliano G, Murri L, Bresolin N, Comi GP.
  • SPG11: a consistent clinical phenotype in a family with homozygous spatacsin truncating mutation. Neurogenetics. 2007 Nov;8(4):301-5. Epub 2007 Aug 24.

    Del Bo R, Di Fonzo A, Ghezzi S, Locatelli F, Stevanin G, Costa A, Corti S, Bresolin N, Comi GP.
  • Absence of angiogenic genes modification in Italian ALS patients. Neurobiol Aging. 2008 Feb;29(2):314-6. Epub 2006 Nov 17.

    Del Bo R, Scarlato M, Ghezzi S, Martinelli-Boneschi F, Corti S, Locatelli F, Santoro D, Prelle A, Briani C, Nardini M, Siciliano G, Mancuso M, Murri L, Bresolin N, Comi GP.
  • QNeural stem cell transplantation can ameliorate the phenotype of a mouse model of spinal muscular atrophy. J Clin Invest. 2008 Oct;118(10):3316-30.

    Corti S, Nizzardo M, Nardini M, Donadoni C, Salani S, Ronchi D, Saladino F, Bordoni A, Fortunato F, Del Bo R, Papadimitriou D, Locatelli F, Menozzi G, Strazzer S, Bresolin N, Comi GP.