Angelo Poletti

The anabolic/androgenic steroid nandrolone exacerbates gene expression modifications induced by mutant SOD1 in muscles of mice models of amyotrophic lateral sclerosis.
Galbiati M, Onesto E, Zito A, Crippa V, Rusmini P, Mariotti R, Bentivoglio M, Bendotti C, Poletti A
Pharmacol. Res. (2011) in press
doi. 10.1016/j.pneurobio.2011.10.001

Dysfunction of constitutive and inducible ubiquitin-proteasome system in amyotrophic lateral sclerosis: Implication for protein aggregation and immune response.
Bendotti C, Marino M, Cheroni C, Fontana E, Crippa V, Poletti A, De Biasi S.
Prog. Neurobiol. (2011) in press
doi. 10.1016/j.phrs.2011.12.001

Alteration of protein folding and degradation in motor neuron diseases: Implications and protective functions of small heat shock proteins.
Carra S, Crippa V, Rusmini P, Boncoraglio A, Minoia M, Giorgetti E, Kampinga HH, Poletti A
Prog. Neurobiol. (2011) in press
doi. 10.1016/j.pneurobio.2011.09.009

Muscle cells and motoneurons differentially remove mutant SOD1 causing familial amyotrophic lateral sclerosis.
Onesto E, Rusmini P, Crippa V, Ferri N, Zito A, Galbiati M, Poletti A
J. Neurochem. (2011) 118(2):266-80
doi. 10.1111/j.1471-4159.2011.07298.x.

Dysregulation of axonal transport and motorneuron diseases.
Sau D, Rusmini P, Crippa V, Onesto E, Bolzoni E, Ratti A, Poletti A.
Biol. Cell. (2011) 103(2):87-107.
doi.

17-AAG Increases Autophagic Removal of Mutant Androgen Receptor in Spinal and Bulbar Muscular Atrophy.
Rusmini P., Simonini F., Crippa V., Cagnin M., Sau D., Onesto E., Bolzoni E., Ferri N., Poletti A.
Neurobiol. Dis. (2011) 41(1):83-95
doi. 10.1016/j.nbd.2010.08.023

Proteasomal and autophagic degradative activities in spinal and bulbar muscular atrophy.
Rusmini P., Bolzoni E., Crippa V., Onesto E., Sau D., Galbiati M., Piccolella M., Poletti A.
Neurobiol. Dis. (2010) 40(2):361-9
doi. 10.1016/j.nbd.2010.06.016

Autophagy Punctum: A role of Small Heat Shock Protein B8 (HspB8) in the autophagic removal of misfolded proteins responsible for neurodegenerative diseases.
Crippa V., Carra S., Rusmini R., Sau D., Bolzoni E., Bendotti C., De Biasi S., Poletti A.
Autophagy (2010) 6(7):958-60
doi. 10.4161/auto.6.7.13042

The androgen derivative 5alpha-androstane-3beta,17beta-diol inhibits tumor necrosis factor α and lipopolysaccharide induced inflammatory response in human endothelial cells and in mice aorta.
Norata G.D., Cattaneo P., Tibolla G., Poletti A., Catapano A.L.
Atherosclerosis (2010) 212(1):100-6
doi. 10.1016/j.atherosclerosis.2010.05.015

The Small Heat Shock Protein B8 (HspB8) promotes removal of misfolded proteins involved in Amyotrophic Lateral Sclerosis (ALS).
Crippa V., Sau D., Onesto E., Galbiati M., Rusmini P., Bolzoni E., Boncoraglio A., Fontana E., Marino M., Carra S., Bendotti C., De Biasi S., Poletti A..
Hum. Mol. Genet. (2010) 19(17):3440-3456.
doi. 10.1093/hmg/ddq257

Estrogen receptor β and the progression of prostate cancer: role of 5a-androstane-3β,17β-diol (3β-Adiol).
Dondi D., Piccolella M., Biserni A., Della Torre S., Ramachandran B., Locatelli A., Rusmini P., Sau D., Maggi A., Ciana P., Poletti A..
Endocrine-Related Cancer (2010) 17(3):731-742.
doi. ERC-10-0032v1-ERC-10-003

Post-translational modifications and expanded polyglutamine toxicity in neurons.
Pennuto M., Palazzolo I., Poletti A..
Hum. Mol. Genetic (2009) 18:R40-47
doi. 10.1093/hmg/ddn412

Androgens Inhibit Androgen Receptor Promoter Activation in Motor Neurons.
Vismara G., Simonini F., Onesto E., Gennaro M., Miceli V., Martini L., Poletti A.
Neurobiol Dis (2009) 25:561-566.
doi: 10.1016/j.nbd.2008.11.007

A presynaptically toxic secreted phospholipase A2 is internalized into motoneuron-like cells where it is rapidly translocated into the cytosol.
Praznikar Z.J., Kovacic L., Rowan E.G., Romih R., Rusmini P., Poletti A, Krizaj I., Pungercar J.
Biochim Biophys Acta - Section Molecular Cell Research (2008) 1783:1129-1139
doi: 10.1016/j.bbamcr.2008.01.011

Androgen regulation of axonal growth in motoneurons.
Fargo K. N., Galbiati M., Poletti A., Jones K.J.
Horm Behav. (2008) 53:716-28
doi: 10.1016/j.yhbeh.2008.01.014

Androgen regulates neuritin mRNA levels in an in vivo model of steroid-enhanced peripheral nerve regeneration.
Fargo K.N., Alexander T.D., Tanzer L., Poletti A, Jones K.J.
J Neurotrauma (2008) 25:561-566
doi: 10.1089/neu.2007.0466

Mutation of the SOD1 in ALS: a Gain of a Loss of function.
Sau D., De Biasi S., Vitellaro-Zuccarello L., Riso P, Guarnieri S, Porrini M, Simeoni S., Crippa V., Onesto E., Palazzolo I., Rusmini P., Bolzoni E., Bendotti C., Poletti A.
Hum Mol Genet (2007) 16:1604-1618

Aggregation and Proteasome: The case of elongated polyglutamine aggregation in Spinal and Bulbar Muscular Atrophy.
Rusmini P., Sau D., Crippa V., Palazzolo I., Simonini F., Onesto E., Martini L., Poletti A.
Neurobiol Aging (2007) 28:1099-1111.

Neuritin (cpg15) enhances the differentiating effect of NGF on neuronal PC12 cells.
Cappelletti G., Galbiati M., Ronchi C., Maggioni M.G., Onesto E., Poletti A.
J Neurosci Res. (2007) doi:
doi: 10.1002/jnr.21235.

The role of the polyglutamine tract in Androgen Receptor.
Palazzolo I., Gliozzi A., Rusmini P., Sau D., Crippa V., Simonini F., Onesto E., Bolzoni E., Poletti A.
J. Steroid Biochem Mol. Biol. (2007)
doi: 10.1016/j.jsbmb.2007.09.016

Lepidium meyenii (Maca) does not exert direct androgenic activities.
Bogania P., Simonini F., Iriti M., Rossoni M., Faoro F., Poletti A., Visioli A.
J. Ethnopharmacol (2006) 104:415-417

Dihydrotestosterone decreases tumor necrosis factor α and lipopolysaccharide induced endothelial inflammatory response.
Norata G.D., Tibolla P., Seccomandi P.M., Poletti A., Catapano A.L.
J Clin Endocrinol Metab (2006) 91:546-554.

Androgen induced neurite outgrowth is mediated by neuritin in motor neuron cells.
Marron T.U., Guerini V., Rusmini P., Brevini T.A.L., Pozzi P., Martini L., Poletti A.
J Neurochem. (2005) 92:10-20

Reflections on the diseases linked to mutations of the androgen receptor.
Poletti A., Negri-Cesi P., Martini L.
Endocrine (2005) 28:243-262.

The Androgen Derivative 5alpha-Androstan-3beta,17beta-diol Inhibits Prostate Cancer Cell Migration throught Activation of Estrogen Receptor beta subtype.
Guerini V., Sau D., Scaccianoce E., Ciana P., Maggi A., Martini P., Katznenellenbogen B., Motta M., Poletti A.
Cancer Res (2005) 65:5445-5453

A novel tool for the study of motor neuron diseases: an NSC-34-tTA cell line for tetracycline-regulated gene expression.
Babetto E., Mangolini A., Rizzardini M., Lupi M., Conforti L., Rusmini P., Poletti A., Cantoni L.
Mol Brain Res (2005) 140:63-72.

Long-term presence of androgens and anti-androgens modulate EGF-receptor expression and MAP-kinase phosphorylation in androgen receptor-prostate positive cancer cells.
Gravina G.C., Angelucci A., Poletti A., Capuano D., Vicentini C., Motta M., Bologna M., Festuccia C.
Int J Oncol (2004) 25: 97-104

The polyglutamine tract of androgen receptor: from functions to dysfunctions in motor neurons
Poletti A.
Frontiers Neuroendocrinol. (2004) 25:1-26.

Androgen 5alpha-reductase type 2 is highly expressed and active in rat spinal cord motor neurones.
Pozzi P., Bendotti C., Simeoni S., Piccioni F., Guerini V., Marron T.U., Martini L., Poletti A.
J Neuroendocrinol (2003) 15, 882-887.

Characterization of Prostate Cancer DU145 Cells Expressing The Recombinant Androgen Receptor.
Scaccianoce E., Festuccia C., Dondi D., Guerini V., Bologna M., Motta M., Poletti A.
Oncol Res (2003) 14, 101-112

Androgen receptor with elongated polyglutamine tract forms aggregates that alter axonal trafficking and mitochondrial distribution in motor neuronal processes.
Piccioni F., Pinton P., Simeoni S., Pozzi P., Fascio U., Martini L., Rizzuto R., Poletti A.
FASEB J. (2002) 16, 1418-1420.
online: FASEB J. (July 18, 2002) 10.1096/fj.01-1035fje

Polyglutamine tract expansion in the androgen receptor in a motorneuronal model of spinal and bulbar muscular atrophy
Piccioni F, Simeoni S., Andriola I., Armatura E., Bassanini S., Pozzi P., Martini L., Poletti A.
Brain Res. Bull. (2001) 56:215-220.

5alpha-reductase type 2 and Androgen receptor compose the androgen responsiveness of the Gonadotropin-releasing hormone (GnRH) GT1-1 neurons.
Poletti A., Rampoldi A., Piccioni F., Ponti N., Simeoni S., Volpi S., Zanisi M., Martini L.
J. Neuroendocrinol. (2001) 13:353-357.

Expression and role of functional glucocorticoid receptors in the human androgen-independent prostate cancer cell line DU145.
Dondi D., Maggi R., Scaccianoce E., Martini L., Motta M., Poletti A.
J Mol. Endocrinol. (2001) 26, 185-191.

Motoneuronal cell death is not correlated with aggregate formation of androgen receptors containing an elongated polyglutamine tract.
Simeoni S., Mancini M.A., Stenoien D., Marcelli M., Weigel N.L., Zanisi M., Martini L., Poletti A.
Hum. Mol. Genet. (2000) 9:133-144.

CAG Expansion in androgen receptor gene and neuronal cell death.
Poletti A.
Research Signpost: Recent Research Developments in Neurochemistry. (2000) 2:507-515. The sexual differentiation of the brain: role of the metabolism of steroid hormones. Negri-Cesi P., Poletti A., Martini L. J Human Oncogen (2000) 3: 22-28

Role of androgens in proliferation and differentiation of mouse mammary epithelial cell line.
Baratta M., Grolli S., Poletti A., Ramoni R., Motta M., Tamanini C.
J. Endocrinol. (2000) 167:53-60.

5alpha-reductase isozymes and aromatase are differentially expressed and active in androgen-independent human prostate cancer cells.
Negri-Cesi P., Colciago A., Poletti A., Motta M.
The Prostate.(1999) 41:224-232.

The 5alpha-reductase isozymes in the Central Nervous System.
Poletti A., Coscarella A., Negri-Cesi P., Colciago A., Celotti F., Martini L.
Steroids (1998) 63:246-251.

Effects and metabolism of steroid hormones in human neuroblastoma cells.
Maggi R., Poletti A., Casulari L.A., Pimpinelli F., Piva F., Zanisi M., Martini L.
Steroids (1998) 63:257-262.

The 5alpha-reductase in the central nervous system: expression and modes of control.
Melcangi C.R., Poletti A., Caravetta I., Celotti F., Colciago A., Magnaghi V., Motta M., Negri-Cesi P., Poletti A., Martini L.
J. Steroid Biochem. Mol. Biol. (1998) 65:295-299.

Androgen-activating enzymes in the central nervous system.
Poletti A., Martini L.
J. Steroid Biochem. Mol. Biol. (1998) 69:117-122

Presence of androgen-activating enzyme in the human prostatic cancer cell line LNCaP and in Begnin prostatic hyperplasia.
Negri-Cesi P., Poletti A., Colciago A., Magni P., Martini P., Motta M.
The Prostate (1998) 34:283-291.

Transient expression of the type 2 5alpha-reductase isozyme in the brain of the late fetal and early post-natal life.
Poletti A., Negri-Cesi P., Rabuffetti M., Colciago A., Celotti F., Martini L.
Endocrinology.(1998) 139: 2171-2178.

Expression of androgen-activating enzymes in cultured cells of developing rat brain.
Poletti A., Negri-Cesi P., Melcangi R.C., Colciago A., Martini L., Celotti F.
J. Neurochem. (1997) 68:1298-1303.

Phosphorylation of human progesterone receptor by Cyclin-dependent kinase 2 on three sites that are authentic basal phosphorylation sites in vivo.
Zhang Y., Beck C.A., Poletti A., Clement IV J.P., Prendergast P., Yip T.-T., Hutchens T.W., Edwards D.P., Weigel N.L.
Mol. Endocrinol.(1997) 11:823-832.

Identification of type 1 5alpha-reductase in myelin membranes of male and female rat brain.
Poletti A., Celotti F., Rumio C., Rabuffetti M., Martini L.
Mol. Cell. Endocr.(1997) 129:181-190.

Steroid metabolism in the mammalian brain: 5alpha-reduction and aromatization.
Celotti F., Negri-Cesi P., Poletti A.
Brain Res.Bull. (1997) 44:365-375.

Characterisation of rat 5alpha-reductases type 1 and type 2 expressed in yeast Saccharomyces cerevisiae.
Poletti A., Celotti F., Motta M., Martini L.
Biochem. J. (1996) 314:1047-1052.

Synthesis of a chemiluminescent probe useful for the purification of steroid 5alpha-reductase
Guarna A., Poletti A., Catrambone F., Danza G., Marrucci A., Serio M., Celotti F., Martini L.
Bioorg. Med. Chem. Lett. (1996) 6:1997-2002.

Luteinizing hormone-releasing hormone (LHRH) agonists interfere with the stimulatory actions of the epidermal growth factor in human prostatic cancer cell lines, LNCaP and DU145.
Moretti R.M., Montagnani-Marelli M., Dondi D., Poletti A., Martini L., Motta M., Limonta P.
J. Clin. Endocr. Metab. (1996) 81:3930-3936.

Effect of suramin on the biological activity of the two isoforms of the rat 5alpha-reductase
Poletti A., Rabuffetti M., Martini L.
Steroids, (1996) 61: 504-505.

Metabolism of steroids in the brain: a new insight in the role of 5alpha-reductase and aromatase in the brain differentiation and functions.
Negri-Cesi P., Poletti A. and Celotti F.
J. Steroid Biochem. Mol. Biol. (1996) 58: 455-466.

Phosphorylation and progesterone receptor function.
Weigel N.L., Bai W., Zhang Y., Beck C.A., Edwards D.P., Poletti A.
J.Steroid Biochem. Mol. Biol. (1996) 53:1-6.

Identification of a group of Ser-Pro motif hormone inducible phosphorylation sites in human progesterone receptor.
Zhang Y., Beck C.A., Poletti A., Edwards D.P., Weigel N.L.
Mol.Endocrinol. (1995) 9:1029-1040.

Steroid binding and metabolism in the LHRH-producing neuronal cell line GT1-1.
Poletti A., Melcangi R.C., Negri-Cesi P., Maggi R., Martini L.
Endocrinology (1994) 135:2623-2628.

 Identification of phosphorylation sites unique to the B form of the human progesterone receptor: in vitro phosphorylation by Casein Kinase II.       
Zhang Y.,. Beck C.A, Poletti A., Edwards D.P., Weigel N.L.
J Biol Chem (1994) 269:31034-31040.

Identification of a Hormone-dependent phosphorylation site adjacent to the DNA binding domain of the chicken progesterone receptor.
Poletti A., Weigel N.L.
Mol Endocrinol (1993) 7, 241-246.

Chicken progesterone receptor expressed in Saccharomyces cerevisiae is correctly phosphorylated at all four Ser-Pro phosphorylation sites.
Poletti A., Conneely O.M., McDonnell D.P., Schrader W.T., O'Malley B.W., Weigel N.L.
Biochemistry (1993) 32,9563-9569

A novel, highly regulated, rapidly inducible system for the expression of chicken progesterone receptor, cPRa, in Saccharomyces cerevisiae.
Poletti A., Weigel N.L., McDonnell D.P., Schrader W.T. and O'Malley B.W.
Gene (1992) 114:51-58.

Kinetics properties of the 5alpha-reductase of testosterone in the purified myelin, in the sub-cortical white matter, and in the cerebral cortex of the male rat brain.
Poletti A., Celotti F., Melcangi R.C., Ballabio M., and Martini L.
J Steroid Biochem (1990) 35:97-101.

5alpha-reductase activity in isolated and cultured neuronal and glial cells of the rat.
Melcangi C., Celotti F., Ballabio M., Castano P., Massarelli R., Poletti A. and Martini L.
Brain Res (1990) 516:229-236.

Testosterone metabolism in peripheral nerves: presence of the 5alpha-reductase 3alpha-hydroxysteroid dehydro- genase enzymatic system in the sciatic nerve of adult and aged rats.
Melcangi R.C., Celotti F., Ballabio M., Poletti A., and Martini L.
J Steroid Biochem (1990) 35:145-148.

Effect of postnatal starvation on the 5alpha-reductase activity of the brain and of the isolated myelin membranes.
Melcangi R.C., Celotti F., Ballabio M., Carnaghi R., Poletti A. and Martini L.
Exp Clin Endocrinol Diab (1989) 94:253-261.

Testosterone 5alpha-reductase activity in the rat brain is highly concentrated in white matter structures and in purified myelin sheaths of axons.
Melcangi R.C., Celotti F., Ballabio M., Poletti A., Castano P., and Martini L.
J Steroid Biochem (1988) 31:173-179.

Ontogenetic development of the 5alpha-reductase in the rat brain: cerebral cortex, hypothalamus, purified myelin and isolated oligodendrocytes.
Melcangi R.C., Celotti F., Ballabio M., Castano P., Poletti A., Milani S. and Martini L.
Dev Brain Res (1988) 44:181-188.

The 5alpha-reductase activity of the subcortical white matter, the cerebral cortex and the hypothalamus of the rat and the mouse: possible sex differences and effect of castration.
Melcangi R.C., Celotti F., Poletti A., Negri-Cesi P. and Martini L.
Steroids (1987) 49:259.