Angelo Poletti

The Chaperone-Assisted Selective Autophagy Complex Dynamics and Dysfunctions.
Tedesco B.°, Vendredy L.°, Timmerman V.*, Poletti A.*
Autophagy (2023) Jan 3:1-23
doi: 10.1080/15548627.2022.2160564 - PMID: 36594740

Identification of HSPB8 modulators counteracting misfolded protein accumulation in neurodegenerative diseases.
Chierichetti A., Cerretani M., Ciammaichella A., Crippa V., Rusmini P., Ferrari V., Tedesco B., Casarotto E., Cozzi M., Mina F., Pramaggiore P., Galbiati M. Piccolella M., Bresciani A., Cristofani R.,* Poletti A.*
Life Sci (2023) 322:121323
doi: 10.1016/j.lfs.2022.121323 - PMID: 36574942

Bicalutamide and trehalose ameliorate spinal and bulbar muscular atrophy pathology in mice.
M. Galbiati, M. Meroni, M. Boido, M. Cescon, P. Rusmini, V. Crippa, R. Cristofani, M. Piccolella, V. Ferrari, E. Casarotto, B. Tedesco, M. Chierichetti, M. Cozzi, F. Mina, M.E. Cicardi, S. Pedretti, N. Mitro, A. Caretto, P. Risè, A. Sala, A. Liebermann, P. Bonaldo, M. Pennuto, A. Vercelli, A. Poletti, A.
Neurotherapeutics (2023) 20(2):524-545
doi: 10.1007/s13311-023-01343-x - PMID: 36717478

Frameshift mutations in the small Heat Shock protein B8 impair the Chaperone Assisted Selective Autophagy challenging proteostasis.
Tedesco B., Vendredy L., Adriaenssens E., Cozzi M., Asselbergh B., Crippa V., Cristofani R., Rusmini P., Ferrari V., Casarotto E., Chierichetti A., Mina F., Pramaggiore P., Galbiati M., Piccolella P., Baets J., Baeke F., De Rycke R., Mouly V., Laurenzi T., Vihola A., Udd B., Eberini I., Vihola A., Udd B., Weiss L., Kimonis V., Timmerman V., Poletti A.
Autophagy (2023) Feb 28;1-23
doi: 10.1080/15548627.2023.2179780 - PMID: 36854646

C9orf72 ALS/FTD dipeptide repeat protein levels are reduced by small molecules that inhibit PKA or enhance protein degradation.
Licata N.V., Cristofani R., Salomonsson S., Wilson K.M., Kempthorne L., Vaizoglu D., D’Agostino V.G., Pollini D., Loffredo R., Pancher M., Adami V., Bellosta P., Ratti a., Viero G., Quattrone A., Isaacs A.M., Poletti A.*, Provenzani A.*
EMBO J (2022) 41:e105026
doi: DOI: 10.15252/embj.2020105026 - PMID: 34791698

RNA molecular signature profiling and nuclear SOD1 localization in PBMCs of sporadic ALS patients: HSP70 overexpression and its implication in DNA damage protection.
M. Garofalo, C. Pandini, M. Bordoni, E. Jacchetti, L. Diamanti. S. Carelli, M.T. Raimondi, D. Sproviero, V. Crippa, S. Carra, A. Poletti A, Pansarasa O., Gagliardi S., Cereda C.
Cells (2022), 11(2):293
doi: 10.3390/cells11020293 - PMID: 35053410

Neurodegenerative disease-associated TDP-43 fragments are extracellularly secreted with CASA complex proteins.
E. Casarotto, D. Sproviero, E. Corridori, M.C. Gagliani, M. Cozzi, M. Chierichetti, R.M. Cristofani, V. Ferrari, M. Galbiati, F. Mina, M. Piccolella, P. Rusmini, B. Tedesco, S. Gagliardi, K. Cortese, C. Cereda, A. Poletti A§, V. Crippa §
Cells (2022) 11(3), 516
doi: 10.3390/cells11030516 - PMID: 35159325

Pathogenic variants of Valosin containing protein induce lysosomal damage and transcriptional activation of autophagy regulators in neuronal cells.
V. Ferrari, R. Cristofani, M.E. Cicardi, B. Tedesco, V. Crippa, M. Chierichetti, E. Casarotto, M. Cozzi, F. Mina, M. Galbiati, M. Piccolella, S. Carra, T. Vaccari, A. Nalbandian, V. Kimonis, T.R. Fortuna, U.B. Pandey, M.C. Gagliani, K. Cortese, P. Rusmini, A. Poletti A.
Neuropathol Appl Neurobiol (2022) 2022;e12818
doi: 10.1111/nan.12818 - PMID: 35501124

Lysosomes dysfunction causes mitophagy impairment in PBMCs of sporadic ALS patients.
M. Bordoni, O. Pansarasa, E. Scarian, R. Cristofani, R. Leone, V. Fantini, M. Garofalo, L. Diamanti, S. Bernuzzi, S. Gagliardi, S. Carelli, A. Poletti A, C. Cereda.
Cells (2022) 11(8):1272
doi: 10.3390/cells11081272 - PMID: 35455952

HSPB8 counteracts tumor activity of BRAF- and NRAS- mutant melanoma cells by modulation of RAS-prenylation and autophagy.
Cristofani R., Piccolella M., Montagnani Marelli M., Tedesco B., Poletti A., * Moretti R.M.
Cell Death Dis (2022) 13(11):973
doi: 10.1038/s41419-022-05365-9 - PMID: 36400750

Insights on human small Heat Shock Proteins and their alterations in human diseases.
Tedesco B., Cristofani R., Ferrari V., Cozzi M., Rusmini P., Casarotto E., Chierichetti M., Mina F., Galbiati M., Piccolella M., Crippa V., Poletti A.
Front Mol Biosci (2022) 9:842149
doi: 10.3389/fmolb.2022.842149 - PMID: 35281256

Valosin Containing Protein (VCP): A Multistep Regulator of Autophagy.
Ferrari V., Cristofani R., Tedesco B., Crippa V., Chierichetti M., Casarotto E., Cozzi M., Mina F., Piccolella M., Galbiati M., Rusmini P., Poletti A
Int J Mol Sci. (2022) Feb 9;23(4):1939
doi: 10.3390/ijms23041939 - PMID: 35216053

The role of autophagy-lysosomal pathway in motor neuron diseases.
Tedesco B.,° Ferrari V.°, Cozzi M., Chierichetti M., Casarotto E., Pramaggiore P., Mina F., Piccolella M., Cristofani R., Crippa V., Rusmini P., Galbiati M., Poletti A.*
Biochem Soc T (2022) BST20220778
doi: 10.1042/BST20220778 - PMID: 36111809

The Role of Small Heat Shock Proteins in Protein Misfolding Associated Motoneuron Diseases.
Tedesco B., Ferrari V., Cozzi M., Chierichetti M., Casarotto E., Pramaggiore P., Mina F., Galbiati M., Rusmini P., Crippa V., Cristofani R., Poletti A
Int J Mol Sci (2022) 23(19), 11759
doi: 10.3390/ijms231911759 - PMID: 36233058

Multilayer and MATR3-dependent regulation of mRNAs maintains pluripotency in human induced pluripotent stem cells.
Pollini D., Loffredo R., Maniscalco F., Cardano M., Micaelli M., Bonomo I., Licata N.V., Peroni D., Tomaszewska W., Rossi A., Crippa V., Dassi E., Viero G., Quattrone A., Poletti A A., Conti L., Provenzani A.
iScience (2021) 2021 Feb 16;24(3):102197
doi: 10.1016/j.isci.2021.102197 - PMID: 33733063

Retinoic acid downregulates HSPB8 gene expression in human breast cancer cells MCF-7.
Piccolella M., Cristofani R., Tedesco B., Chierichetti M., Ferrari V., Casarotto E., Cozzi M., Crippa V., Rusmini P., Galbiati M., Poletti A.*^, Messi E.^
Front Oncol. (2021) May 31;11:652085
doi: 10.3389/fonc.2021.652085 - PMID: 34136389

Dysregulation of myomiRs as common pathogenic feature associated with muscle atrophy in ALS, SMA and SBMA: evidence from animal models and human patients.
Malacarne C., Galbiati M., Giagnorio E., Cavalcante P., Salerno F., Andreetta F., Cagnoli C., Taiana N., Nizzardo M., Corti S., Pensato V., Venerando A., Gellera C., Fenu S., Pareyson D., Masson R., Maggi L., Dalla Bella E., Lauria P., Mantegazza R., Bernasconi P., Poletti A*., Bonanno S., Marcuzzo S.
Int J Med Sci (2021) 22(11):5673
doi: 10.3390/ijms22115673 - PMID: 34073630

Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (4th edition).
Klionsky D.J., et al, ....Poletti A., et al., ..... Tong CK.
Autophagy. 2021 17(1):1-382
doi: 10.1080/15548627.2020.1797280 - PMID: 33634751

The role of HSPB8, a component of the chaperone assisted selective autophagy machinery, in cancer.
Cristofani R., Piccolella M., Crippa V., Tedesco B., Montagnani Marelli M., Poletti A A.*, Moretti R.M.
Cells (2021) Feb 5;10(2):335
doi: 10.3390/cells10020335 - PMID: 33562660

The role of sex and sex Hormones in Neurodegenerative Diseases.
Vegeto E., Villa A., Della Torre S., Crippa V. Rusmini P., Cristofani R., Galbiati M., Maggi A., Poletti A.
Endocrine Rev. (2020) 41:273-319
doi: 10.1210/endrev/bnz005 - PMID: 27196727

A crucial role for the protein quality control system in motor neuron diseases.
Cristofani R., Crippa V., Cicardi M.E. , Tedesco B., Ferrari V., Chierichetti M. , Casarotto E., Piccolella M., Messi E., Galbiati M., Rusmini P., Poletti A.
Frontiers in Aging Neuroscience (2020) 12:191
doi: 10.3389/fnagi.2020.00191 - PMID: 32792938

Combinatorial treatment for spinal muscular atrophy.
Poletti A A., Fischbeck K.H.
J Neurochem (2020) 153:146-149
doi: 10.1111/jnc.14974 - PMID: 32056234

Multiple roles of Transforming Growth Factor beta in Amyotrophic Lateral Sclerosis.
Galbiati M., Crippa V., Rusmini P., Cristofani R., Messi E., Piccolella M., Tedesco B., Ferrari V., Chierichetti M., Casarotto E., Poletti A.*
Int J Mol Sci. (2020) 21(12):4291
doi: 10.3390/ijms21124291 - PMID: 32560258

HSC70 expression is reduced in lymphomonocytes of sporadic ALS patients and contributes to TDP-43 accumulation.
Arosio A., Cristofani R., Pansarasa O., Crippa V., Riva C., Sirtori R., Menendez V., Riva N., Gerardi F., Lunetta C., Cereda C., Poletti A A., Ferrarese C., Tremolizzo L., Sala G.
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration (2020) 21(1-2):51-62
doi: 10.1080/21678421.2019.1672749 - PMID: 31663379

BAG3 Pro209 mutants associated with myopathy and neuropathy sequester chaperones of the CASA-complex in aggresomes.
Adriaenssens E.°, Tedesco B.,° Mediani L., Asselbergh B., Crippa V., Antoniani F., Carra S.*, Poletti A A.*, Timmerman V.*
Sci Rep (2020) 10(1):8755
doi: 10.1038/s41598-020-65664-z - PMID: 32472079

Enhanced clearance of neurotoxic misfolded proteins by the natural compound berberine and its derivatives.
Rusmini P., Cristofani R., Tedesco B., Ferrari V., Messi E., Piccolella M., Casarotto E., Chierichetti M., Cicardi M.E., Galbiati M., Geroni G., Lombardi P., Crippa V., Poletti A A.
Int. J Mol Sci (2020) 21:3443
doi: 10.3390/ijms21103443 - PMID: 32414108

FUS pathology in ALS is linked to alterations in multiple ALS-associated proteins and rescued by drugs stimulating autophagy.
Marrone L., Drexler D., Wang J., Tripathi P., Distler T., Heisterkamp P., Anderson E.N., Kour S., Moraiti A., Maharana S., Bhatnagar R., Belgard G., Tripathy V., Kalmbach N., Hosseinzadeh Z., Crippa V., Abo-Rady M., Wegner F., Poletti A A., Troos D., Aronica E., Busskamp V., Weis J., Pandey U.B., Hyman A.A., Alberti S., Goswami A., Sterneckert J.
Acta Neuropathol. (2019) 138:67-84
doi: 10.1007/s00401-019-01998-x - PMID: 30937520

Proteostasis and ALS: protocol for a phase II, randomized, double blind, placebo controlled, multicenter clinical trial for Colchicine in ALS (Co-ALS) .
Mandrioli J., Crippa V., Cereda C., Bonetto V., Zucchi E., Gessani A., Ceroni M., Chiò A., D'Amico R., Monsurrò M.R., Riva N., Sabatelli M., Silani V., Simone I.L., Sorarù G., Provenzani A., D’Agostino V.G., Carra S., Poletti A.
British Med J Open (2019) 9:e028486
doi: 10.1136/bmjopen-2018-028486 - PMID: 31152038

Nuclear phospho-SOD1 protects DNA from oxidative stress damage in Amyotrophic Lateral Sclerosis.
Bordoni M., Pansarasa O., Dell'Orco M., Crippa V., Gagliardi S., Sproviero D., Bernuzzi S., Diamanti L., Ceroni M., Tedeschi G., Poletti A A., Cereda C.
J Clin Med. (2019) 8:E729
doi: 10.3390/jcm8050729 - PMID: 31121901

Transforming growth factor beta 1 signaling is altered in the spinal cord and muscle of amyotrophic lateral sclerosis mice and patients.
Meroni M., Crippa V., Cristofani R., Rusmini P., Cicardi M.E., Messi E., Piccolella M., Tedesco B., Ferrari V., Sorarù G., M., Pennuto M, Poletti A.,* Galbiati M
Neurobiol Aing (2019) 82:48-59
doi: 10.1016/j.neurobiolaging.2019.07.001 - PMID: 31394426

Autophagic and proteasomal mediated removal of mutant androgen receptor in muscle models of spinal and bulbar muscular atrophy.
Cicardi M.E, Cristofani R., Crippa V., Ferrari V., Tedesco B., Casarotto E., Chierichetti M., Galbiati M., Piccolella M., Messi E., Carra S., Pennuto M., Rusmini P., Poletti A.
Frontiers Endocrinol (2019) 10:569
doi: 10.3389/fendo.2019.00569 - PMID: 31481932

The regulation of the small heat shock protein B8 in misfolding protein diseases causing motoneuronal and muscle cell death.
Cristofani R., Rusmini P., Galbiati M., Cicardi M.E., Ferrari V., Tedesco B., Casarotto E., Chierichetti M., Messi E., Piccolella M., Carra S., Crippa V., Poletti A.
Front Neurosci, section Neuropharmacology (2019) 13:796
doi: 10.3389/fnins.2019.00796 - PMID: 31427919

Concurrent AFG3L2 and SPG7 mutations associated with syndromic parkinsonism and optic atrophy with aberrant OPA1 processing and mitochondrial network fragmentation
Magri S., Fracasso V., Plumari M., Alfei E., Ghezzi D., Gellera C., Rusmini P., Poletti A, Di Bella D., Elia A.E., Pantaleoni C., Taroni F.
Human Mutation (2018) in press
doi: 10.1002/humu.23658

Pathological proteins are specifically transported by extracellular vesicles of sporadic Amyotrophic Lateral Sclerosis patients.
Sproviero D., La Salvia S., Giannini M., Crippa V., Gagliardi S., Bernuzzi S., Diamanti L., Ceroni M., Pansarasa O., Poletti A, Cereda C.
Front Neurosci (2018) 12:487.
doi: 10.3389/fnins.2018.00487

Trehalose induces autophagy via lysosomal-mediated TFEB activation, in models of motoneuron degeneration.
Rusmini P., Cortese K., Crippa V., Cristofani R., Cicardi M. E., Ferrari V., Vezzoli G., Tedesco B., Meroni M., Messi E., Piccolella M., Galbiati M., Garrè M., Morelli E., Vaccari T., Poletti A
Autophagy. 2018 Oct 18:1-21
doi: 10.1080/15548627.2018.1535292

Dual role of autophagy on docetaxel-sensitivity in prostate cancer cells
Cristofani R., Montagnani Marelli M., Cicardi M.E., Fontana F., Marzagalli M., Limonta P., Poletti A, Moretti R.M.
Cell Death Dis. (2018) 9:889
doi: 10.1038/s41419-018-0866-5

TDP25 routing to autophagy and proteasome ameliorates its aggregation in motorneurons and muscle cells.
Cicardi M.E., Cristofani R., Rusmini P., Meroni M., Ferrari V., Vezzoli G., Tedesco B., Piccolella M., Messi E., Galbiati M., Boncoraglio A., Carra S., Crippa V., Poletti A
Sci Rep. 2018, 8:12390
doi: 10.1038/s41598-018-29658-2

Isogenic FUS-eGFP iPSC Reporter Lines Enable Quantification of FUS Stress Granule Pathology that Is Rescued by Drugs Inducing Autophagy.
Marrone L., Poser I., Casci I., Japtok J., Reinhardt P., Janosch A., Andree C., Lee H.O., Moebius C., Koerner E., Reinhardt L., Cicardi M.E., Hackmann K., Klink B., Poletti A., Alberti S., Bickle M., Hermann A., Pandey U.B., Hyman A.A., Sterneckert J.L.
Stem Cell Reports. 2018 Feb 13;10(2):375-389.
doi: 10.1016/j.stemcr.2017.12.018.

The small heat shock protein B8 (HSPB8) efficiently removes aggregating species of dipeptides produced in C9ORF72-related neurodegenerative diseases.
Cristofani R., Crippa V., Vezzoli G., Rusmini P., Galbiati M., Cicardi M.E., Meroni M., Ferrari V., Tedesco B., Piccolella M., Messi E., Carra S., Poletti A.
Cell Stress Chaperones. 2018 Jan;23(1):1-12.
doi: 10.1007/s12192-017-0806-9.

Quantitative assessment of the degradation of aggregated TDP-43 mediated by the ubiquitin proteasome system and macroautophagy.
Cascella R., Fani G., Capitini C., Rusmini P., Poletti A., Cecchi C., Chiti F.
FASEB J. 2017 Dec;31(12):5609-5624.
doi: 10.1096/fj.201700292RR.

Inhibition of retrograde transport modulates misfolded protein accumulation and clearance in motoneuron diseases.
Cristofani R., Crippa V., Rusmini P., Cicardi M.E., Meroni M., Licata N.V., Sala G., Giorgetti E., Grunseich C., Galbiati M., Piccolella M., Messi E., Ferrarese C., Carra S., Poletti A.
Autophagy. 2017 Aug 3;13(8):1280-1303.
doi: 10.1080/15548627.2017.1308985.

The growing world of small heat shock proteins: from structure to functions.
Carra S., Alberti S., Arrigo P.A., Benesch J.L., Benjamin I.J., Boelens W., Bartelt-Kirbach B., Brundel B.J.J.M., Buchner J., Bukau B., Carver J.A., Ecroyd H., Emanuelsson C., Finet S., Golenhofen N., Goloubinoff P., Gusev N., Haslbeck M., Hightower L.E., Kampinga H.H., Klevit R.E., Liberek K., Mchaourab H.S., McMenimen K.A., Poletti A., Quinlan R., Strelkov S.V., Toth M.E., Vierling E., Tanguay R.M.
Cell Stress Chaperones. 2017 Jul;22(4):601-611.
doi: 10.1007/s12192-017-0787-8.

The Role of the Heat Shock Protein B8 (HSPB8) in Motoneuron Diseases.
Rusmini P., Cristofani R., Galbiati M., Cicardi M.E., Meroni M., Ferrari V., Vezzoli G., Tedesco B., Messi E., Piccolella M., Carra S., Crippa V., Poletti A.
Front Mol Neurosci. 2017 Jun 21;10:176.
doi: 10.3389/fnmol.2017.00176.

Functional interaction between FUSand SMN underlies SMA-like splicing changes in wild-type hFUS mice.
Mirra A., Rossi S., Scaricamazza S., Di Salvio M., Salvatori I., Valle C., Rusmini P., Poletti A., Cestra G., Carrì M.T., Cozzolino M.
Sci Rep. 2017 May 17;7(1):2033.
doi: 10.1038/s41598-017-02195-0.

The small heat shock protein B8 (HSPB8) modulates proliferation and migration of breast cancer cells.
Piccolella M., Crippa V., Cristofani R., Rusmini P., Galbiati M., Cicardi M.E., Meroni M., Ferri N., Morelli F.F., Carra S., Messi E., Poletti A.
Oncotarget. 2017 Feb 7;8(6):10400-10415.
doi: 10.18632/oncotarget.14422.

Estrogens, Neuroinflammation, and Neurodegeneration.
Villa A., Vegeto E., Poletti A., Maggi A.
Endocr Rev. (2016) Aug;37(4):372-402.
doi: 10.1210/er.2016-1007.

A surveillance function of the HSPB8-BAG3-HSP70 chaperone complex ensures stress granule integrity and dynamism.
Ganassi M., Mateju D., Bigi I., Mediani L., Poser I., Lee H.O., Seguin S.J., Morelli F.F., Vinet J., Leo G., Pansarasa O., Cereda C., Poletti A., Alberti S., Carra S.
Mol Cell (2016) Sep 1;63(5):796-810 [Aug 25. pii: S1097-2765(16)30374-4]
doi: 10.1016/j.molcel.2016.07.021

Transcriptional induction of the heat shock protein B8 mediates the clearance of misfolded proteins responsible for motor neuron diseases.
Crippa V., D'Agostino V.G., Cristofani R., Rusmini P., Cicardi M.E., Messi E., Loffredo R., Pancher M., Piccolella M., Galbiati M., Meroni M., Cereda C., Carra S., Provenzani A., Poletti A.
Sci. Rep. (2016) 6, 22827; doi: 10.1038/srep22827 .
doi: 10.1038/srep22827

Loss-of-function mutations in the SIGMAR1 gene cause distal hereditary motor neuropathy by impairing ER-mitochondria tethering and Ca2+ signaling.
Gregianin E., Pallafacchina G, Zanin S, Crippa V., Rusmini P., Poletti A., Fang M., Li Z., Diano L., Petrucci A., Lispi L., Cavallaro T., Fabrizi G.M., Muglia M., Boaretto F, Vettori A, Rizzuto R, Mostacciuolo M.L., Vazza G.
Hum Mol Genet. (2016) Sep 1;25(17):3741-3753
doi: 10.1093/hmg/ddw220

The chaperone HSPB8 reduces the accumulation of truncated TDP-43 species in cells and protects against TDP-43-mediated toxicity.
Crippa V., Cicardi M.E., Ramesh N., Seguin S.J., Ganassi M., Bigi I., Diacci C., Zelotti E., Baratashvili M., Gregory J.M., Dobson C.M., Cereda C, Pandey U.B., Poletti A., Carra S.
Hum Mol Genet (2016) Sep 15;25(18):3908-3924
doi: 10.1093/hmg/ddw232

Exome sequencing identifies variants in two genes encoding the LIM-proteins NRAP and FHL1 in an Italian patient with BAG3 myofibrillar myopathy.
D'Avila F., Meregalli M., Lupoli S., Barcella M., Orro A., De Santis F., Sitzia C., Farini A., D'Ursi P., Erratico S., Cristofani R., Milanesi L., Braga D., Cusi D., Poletti A., Barlassina C., Torrente Y.
J Muscle Res Cell Motil. (2016) Jun;37(3):101-15
doi: 10.4172/2168-975X.1000e121

Muscle cells: motor neuron targets and contributors of their disorders
Galbiati M., Crippa V., Poletti A.
Brain Disord Ther (2015) 4:3
doi: 10.1007/s10974-016-9451-7

Research and clinical management of patients with spinal and bulbar muscular atrophy.
M. Pennuto, L. Greensmith, P. Pradat, G. Sorarù, A. Baniahmad, M. Basso, A. Cato, K. Fischbeck, J. Finsterer, P. Fratta, I. Gozes, M. Jokela, D. Pareyson, A. Poletti, C. Rinaldi, X. Salvatella, J. Vissing, P. Weydt
Neuromuscular Disord (2015) 25(10):802-12
doi: 10.1016/j.nmd.2015.06.462

Differences in protein quality control contribute to phenotype variability in two mouse models of familial amyotrophic lateral sclerosis.
Marino M., Papa S., Crippa V., Nardo G., Peviani M., Cheroni C., Trolese M.C., Lauranzano E., Bonetto V., Poletti A., DeBiasi S., Ferraiuolo L., Shaw P.J., Bendotti C.
Neurobiol Aging (2015) 36:492-504.
doi: 10.1016/j.neurobiolaging.2014.06.026

Synergic pro-degradative activity of trehalose and bicalutamide on the mutant Androgen Receptor responsible for Spinal and Bulbar Muscular Atrophy.
Giorgetti E., Rusmini P., Crippa V., Cristofani R., Boncoraglio A., Cicardi M.E., Galbiati M., Poletti A.
Hum Mol Genet (2015) 24(1):64-75
doi: 10.1093/hmg/ddu419

Aberrant autophagic response in the muscle of a knock-in mouse model of Spinal and Bulbar Muscular Atrophy
Rusmini P., Polanco M.J., Cristofani R., Cicardi M.E., Meroni M., Galbiati M., Piccolella M., Messi E., Giorgetti E., Lieberman A., Milioto C., Rocchi A., Aggarwal T., Pennuto M., Crippa V., Poletti A.
Sci. Rep. 5, 15174; doi: 10.1038/srep15174 (2015)
doi: 10.1038/srep15174

Human Adipose-derived Mesenchymal Stem Cells as a new model of Spinal and Bulbar Muscular Atrophy.
Dossena M., Bedini G., Rusmini P., Canazza A., Giorgetti E., Tosetti V., Salsano E., Sagnelli A., Navone S., Marfia G., Alessandri G., Corsi F., Fischbeck K.H., Parati E.A., Pareyson D., Poletti A.
Plos ONE (2014) 9(11):e112746
doi: 10.1371/journal.pone.0112746

Neuritin 1 promotes migration of immortalized neurons modulating microtubule stability
Zito A, Cartelli D, Cappelletti G, Cariboni A, Poletti A, Galbiati M
Struct Funct (2014) 219(1):105-118
doi. 10.1007/s00429-012-0487-1

Androgens affect muscle, motor neuron and survival of a mouse model of SOD1-related amyotrophic lateral sclerosis.
Aggarwal T., Polanco M.J., Scaramuzzino C., Rocchi A., Milioto C., Emionite L., Ognio E., Sambataro F., Galbiati M., Poletti A, Pennuto M.
Neurobiol Aging (2014) 35:1929-1938.
doi: 10.1016/j.neurobiolaging.2014.02.004

BAG3 induces the sequestration of proteasomal clients into cytoplasmic puncta: implication for a proteasome-to-autophagy switch
Minoia M., Boncoraglio A., Vinet J., Morelli F., Brunsting J.F., Poletti A, Krom S., Reits E., Kampinga H.H., Carra S.
Autophagy (2014) 10(9):1603-21
doi: 10.4161/auto.29409

Inhibition of autophagy, lysosome and VCP function impairs stress granule assembly
Seguin S.J., Morelli F.F., Vinet J., Amore D., Poletti A, Rubinsztein D.C., Carra S.
Cell Death Diff (2014) 21(12):1838-51
doi: 10.1038/cdd.2014.103

Clearance of the mutant AR in motoneuronal models of Spinal and Bulbar Muscular Atrophy
Rusmini P., Crippa V., Giorgetti E., Boncoraglio A., Cristofani R., Carra S., Poletti A
Neurobiol Aging (2013) 34(11): 2585–2603.
doi: 10.1016/j.neurobiolaging.2013.05.026

Androgen receptor activation by polychlorinated biphenyls: epigenetic effects mediated by the histone demethylase Jarid1b.
Casati L., Sendra R., Poletti A, Negri-Cesi P., Celotti F.
Epigenetics (2013) 8(10):1061-1068
doi: 10.4161/epi.25811

Modulators of Estrogen Receptor inhibit proliferation and migration of prostate cancer cells.
Piccolella M., Crippa V., Messi E., Tetel M.J., Poletti A
Pharmacol Res 79C (2014) 13-20
doi: 10.1016/j.phrs.2013.10.002

Differential autophagy power in the spinal cord and muscle of transgenic ALS mouse models.
Crippa V., Boncoraglio A., Galbiati R., Aggarwal T., Rusmini P., Giorgetti E., Cristofani R., Carra S., Pennuto M., Poletti A
Front. Cell. Neurosci. (2013) 7:23
doi: 10.3389/fncel.2013.00234

Motor neuronal and muscle selective removal of ALS-related misfolded proteins.
Crippa V., Galbiati M., Boncoraglio A., Rusmini R., Onesto E., Giorgetti E., Cristofani R., Zito A., Poletti A
Biochem. Soc. Trans. (2013) 41(6) 1598-1604.
doi:10.1042/BST20130118

Different anti-aggregation and pro-degradative functions of the members of the mammalian sHSP family in neurological disorders.
Carra S, Rusmini P, Crippa V, Giorgetti E, Boncoraglio A, Naujock N, Meister M, Minoia M, Kampinga HH, Poletti A
Philos T R Soc B (2013) 368: (1617):20110409
doi: 10.1098/rstb.2011.0409

The neurotoxicity of mutant proteins 20 years after the discovery of the first mutant gene involved in neurodegeneration
Poletti A, Cattaneo E, Taroni F
Prog Neurobiol (2012) 97:53
doi. 10.1016/j.pneurobio.2012.04.006

Guidelines for the use and interpretation of assays for monitoring autophagy.
Klionsky DJ, altri autori, Poletti A, altri autori, Zuckerbraun B.
Autophagy (2012) 8:1–100
doi. http://dx.doi.org/10.4161/auto.8.4.19496

CAG repeat length in androgen receptor gene is not associated with amyotrophic lateral sclerosis
Bruson A, Sambataro F, Querin G, D'Ascenzo C, Palmieri A, Agostini J, Gaiani A, Angelini C, Galbiati M, Poletti A, Pennuto M, Pegoraro E, Clementi M, Soraru' G
Eur J Neurol (2012) 19:1373-1375
10.1111/j.1468-1331.2011.03646.x

The anabolic/androgenic steroid nandrolone exacerbates gene expression modifications induced by mutant SOD1 in muscles of mice models of amyotrophic lateral sclerosis.
Galbiati M, Onesto E, Zito A, Crippa V, Rusmini P, Mariotti R, Bentivoglio M, Bendotti C, Poletti A
Pharmacol. Res. (2012) 65:221-230
doi. 10.1016/j.phrs.2011.12.001

Dysfunction of constitutive and inducible ubiquitin-proteasome system in amyotrophic lateral sclerosis: Implication for protein aggregation and immune response.
Bendotti C, Marino M, Cheroni C, Fontana E, Crippa V, Poletti A, De Biasi S.
Prog. Neurobiol. (2012) 97:101-126
doi. 10.1016/j.phrs.2011.12.001

Alteration of protein folding and degradation in motor neuron diseases: Implications and protective functions of small heat shock proteins.
Carra S, Crippa V, Rusmini P, Boncoraglio A, Minoia M, Giorgetti E, Kampinga HH, Poletti A
Prog. Neurobiol. (2012) 97:83-100
doi. 10.1016/j.pneurobio.2011.09.009

Muscle cells and motoneurons differentially remove mutant SOD1 causing familial amyotrophic lateral sclerosis.
Onesto E, Rusmini P, Crippa V, Ferri N, Zito A, Galbiati M, Poletti A
J. Neurochem. (2011) 118(2):266-80
doi. 10.1111/j.1471-4159.2011.07298.x.

Dysregulation of axonal transport and motorneuron diseases.
Sau D, Rusmini P, Crippa V, Onesto E, Bolzoni E, Ratti A, Poletti A.
Biol. Cell. (2011) 103(2):87-107.
doi. 10.1042/BC20100093

17-AAG Increases Autophagic Removal of Mutant Androgen Receptor in Spinal and Bulbar Muscular Atrophy.
Rusmini P., Simonini F., Crippa V., Cagnin M., Sau D., Onesto E., Bolzoni E., Ferri N., Poletti A.
Neurobiol. Dis. (2011) 41(1):83-95
doi. 10.1016/j.nbd.2010.08.023

Proteasomal and autophagic degradative activities in spinal and bulbar muscular atrophy.
Rusmini P., Bolzoni E., Crippa V., Onesto E., Sau D., Galbiati M., Piccolella M., Poletti A.
Neurobiol. Dis. (2010) 40(2):361-9
doi. 10.1016/j.nbd.2010.06.016

Autophagy Punctum: A role of Small Heat Shock Protein B8 (HspB8) in the autophagic removal of misfolded proteins responsible for neurodegenerative diseases.
Crippa V., Carra S., Rusmini R., Sau D., Bolzoni E., Bendotti C., De Biasi S., Poletti A.
Autophagy (2010) 6(7):958-60
doi. 10.4161/auto.6.7.13042

The androgen derivative 5alpha-androstane-3beta,17beta-diol inhibits tumor necrosis factor α and lipopolysaccharide induced inflammatory response in human endothelial cells and in mice aorta.
Norata G.D., Cattaneo P., Tibolla G., Poletti A., Catapano A.L.
Atherosclerosis (2010) 212(1):100-6
doi. 10.1016/j.atherosclerosis.2010.05.015

The Small Heat Shock Protein B8 (HspB8) promotes removal of misfolded proteins involved in Amyotrophic Lateral Sclerosis (ALS).
Crippa V., Sau D., Onesto E., Galbiati M., Rusmini P., Bolzoni E., Boncoraglio A., Fontana E., Marino M., Carra S., Bendotti C., De Biasi S., Poletti A..
Hum. Mol. Genet. (2010) 19(17):3440-3456.
doi. 10.1093/hmg/ddq257

Estrogen receptor β and the progression of prostate cancer: role of 5a-androstane-3β,17β-diol (3β-Adiol).
Dondi D., Piccolella M., Biserni A., Della Torre S., Ramachandran B., Locatelli A., Rusmini P., Sau D., Maggi A., Ciana P., Poletti A..
Endocrine-Related Cancer (2010) 17(3):731-742.
doi. ERC-10-0032v1-ERC-10-003

Post-translational modifications and expanded polyglutamine toxicity in neurons.
Pennuto M., Palazzolo I., Poletti A..
Hum. Mol. Genetic (2009) 18:R40-47
doi. 10.1093/hmg/ddn412

Androgens Inhibit Androgen Receptor Promoter Activation in Motor Neurons.
Vismara G., Simonini F., Onesto E., Gennaro M., Miceli V., Martini L., Poletti A.
Neurobiol Dis (2009) 25:561-566.
doi: 10.1016/j.nbd.2008.11.007

A presynaptically toxic secreted phospholipase A2 is internalized into motoneuron-like cells where it is rapidly translocated into the cytosol.
Praznikar Z.J., Kovacic L., Rowan E.G., Romih R., Rusmini P., Poletti A, Krizaj I., Pungercar J.
Biochim Biophys Acta - Section Molecular Cell Research (2008) 1783:1129-1139
doi: 10.1016/j.bbamcr.2008.01.011

Androgen regulation of axonal growth in motoneurons.
Fargo K. N., Galbiati M., Poletti A., Jones K.J.
Horm Behav. (2008) 53:716-28
doi: 10.1016/j.yhbeh.2008.01.014

Androgen regulates neuritin mRNA levels in an in vivo model of steroid-enhanced peripheral nerve regeneration.
Fargo K.N., Alexander T.D., Tanzer L., Poletti A, Jones K.J.
J Neurotrauma (2008) 25:561-566
doi: 10.1089/neu.2007.0466

Mutation of the SOD1 in ALS: a Gain of a Loss of function.
Sau D., De Biasi S., Vitellaro-Zuccarello L., Riso P, Guarnieri S, Porrini M, Simeoni S., Crippa V., Onesto E., Palazzolo I., Rusmini P., Bolzoni E., Bendotti C., Poletti A.
Hum Mol Genet (2007) 16:1604-1618

Aggregation and Proteasome: The case of elongated polyglutamine aggregation in Spinal and Bulbar Muscular Atrophy.
Rusmini P., Sau D., Crippa V., Palazzolo I., Simonini F., Onesto E., Martini L., Poletti A.
Neurobiol Aging (2007) 28:1099-1111.

Neuritin (cpg15) enhances the differentiating effect of NGF on neuronal PC12 cells.
Cappelletti G., Galbiati M., Ronchi C., Maggioni M.G., Onesto E., Poletti A.
J Neurosci Res. (2007) doi:
doi: 10.1002/jnr.21235.

The role of the polyglutamine tract in Androgen Receptor.
Palazzolo I., Gliozzi A., Rusmini P., Sau D., Crippa V., Simonini F., Onesto E., Bolzoni E., Poletti A.
J. Steroid Biochem Mol. Biol. (2007)
doi: 10.1016/j.jsbmb.2007.09.016

Lepidium meyenii (Maca) does not exert direct androgenic activities.
Bogania P., Simonini F., Iriti M., Rossoni M., Faoro F., Poletti A., Visioli A.
J. Ethnopharmacol (2006) 104:415-417

Dihydrotestosterone decreases tumor necrosis factor α and lipopolysaccharide induced endothelial inflammatory response.
Norata G.D., Tibolla P., Seccomandi P.M., Poletti A., Catapano A.L.
J Clin Endocrinol Metab (2006) 91:546-554.

Androgen induced neurite outgrowth is mediated by neuritin in motor neuron cells.
Marron T.U., Guerini V., Rusmini P., Brevini T.A.L., Pozzi P., Martini L., Poletti A.
J Neurochem. (2005) 92:10-20

Reflections on the diseases linked to mutations of the androgen receptor.
Poletti A., Negri-Cesi P., Martini L.
Endocrine (2005) 28:243-262.

The Androgen Derivative 5alpha-Androstan-3beta,17beta-diol Inhibits Prostate Cancer Cell Migration throught Activation of Estrogen Receptor beta subtype.
Guerini V., Sau D., Scaccianoce E., Ciana P., Maggi A., Martini P., Katznenellenbogen B., Motta M., Poletti A.
Cancer Res (2005) 65:5445-5453

A novel tool for the study of motor neuron diseases: an NSC-34-tTA cell line for tetracycline-regulated gene expression.
Babetto E., Mangolini A., Rizzardini M., Lupi M., Conforti L., Rusmini P., Poletti A., Cantoni L.
Mol Brain Res (2005) 140:63-72.

Long-term presence of androgens and anti-androgens modulate EGF-receptor expression and MAP-kinase phosphorylation in androgen receptor-prostate positive cancer cells.
Gravina G.C., Angelucci A., Poletti A., Capuano D., Vicentini C., Motta M., Bologna M., Festuccia C.
Int J Oncol (2004) 25: 97-104

The polyglutamine tract of androgen receptor: from functions to dysfunctions in motor neurons
Poletti A.
Frontiers Neuroendocrinol. (2004) 25:1-26.

Androgen 5alpha-reductase type 2 is highly expressed and active in rat spinal cord motor neurones.
Pozzi P., Bendotti C., Simeoni S., Piccioni F., Guerini V., Marron T.U., Martini L., Poletti A.
J Neuroendocrinol (2003) 15, 882-887.

Characterization of Prostate Cancer DU145 Cells Expressing The Recombinant Androgen Receptor.
Scaccianoce E., Festuccia C., Dondi D., Guerini V., Bologna M., Motta M., Poletti A.
Oncol Res (2003) 14, 101-112

Androgen receptor with elongated polyglutamine tract forms aggregates that alter axonal trafficking and mitochondrial distribution in motor neuronal processes.
Piccioni F., Pinton P., Simeoni S., Pozzi P., Fascio U., Martini L., Rizzuto R., Poletti A.
FASEB J. (2002) 16, 1418-1420.
online: FASEB J. (July 18, 2002) 10.1096/fj.01-1035fje

Polyglutamine tract expansion in the androgen receptor in a motorneuronal model of spinal and bulbar muscular atrophy
Piccioni F, Simeoni S., Andriola I., Armatura E., Bassanini S., Pozzi P., Martini L., Poletti A.
Brain Res. Bull. (2001) 56:215-220.

5alpha-reductase type 2 and Androgen receptor compose the androgen responsiveness of the Gonadotropin-releasing hormone (GnRH) GT1-1 neurons.
Poletti A., Rampoldi A., Piccioni F., Ponti N., Simeoni S., Volpi S., Zanisi M., Martini L.
J. Neuroendocrinol. (2001) 13:353-357.

Expression and role of functional glucocorticoid receptors in the human androgen-independent prostate cancer cell line DU145.
Dondi D., Maggi R., Scaccianoce E., Martini L., Motta M., Poletti A.
J Mol. Endocrinol. (2001) 26, 185-191.

Motoneuronal cell death is not correlated with aggregate formation of androgen receptors containing an elongated polyglutamine tract.
Simeoni S., Mancini M.A., Stenoien D., Marcelli M., Weigel N.L., Zanisi M., Martini L., Poletti A.
Hum. Mol. Genet. (2000) 9:133-144.

CAG Expansion in androgen receptor gene and neuronal cell death.
Poletti A.
Research Signpost: Recent Research Developments in Neurochemistry. (2000) 2:507-515. The sexual differentiation of the brain: role of the metabolism of steroid hormones. Negri-Cesi P., Poletti A., Martini L. J Human Oncogen (2000) 3: 22-28

Role of androgens in proliferation and differentiation of mouse mammary epithelial cell line.
Baratta M., Grolli S., Poletti A., Ramoni R., Motta M., Tamanini C.
J. Endocrinol. (2000) 167:53-60.

5alpha-reductase isozymes and aromatase are differentially expressed and active in androgen-independent human prostate cancer cells.
Negri-Cesi P., Colciago A., Poletti A., Motta M.
The Prostate.(1999) 41:224-232.

The 5alpha-reductase isozymes in the Central Nervous System.
Poletti A., Coscarella A., Negri-Cesi P., Colciago A., Celotti F., Martini L.
Steroids (1998) 63:246-251.

Effects and metabolism of steroid hormones in human neuroblastoma cells.
Maggi R., Poletti A., Casulari L.A., Pimpinelli F., Piva F., Zanisi M., Martini L.
Steroids (1998) 63:257-262.

The 5alpha-reductase in the central nervous system: expression and modes of control.
Melcangi C.R., Poletti A., Caravetta I., Celotti F., Colciago A., Magnaghi V., Motta M., Negri-Cesi P., Poletti A., Martini L.
J. Steroid Biochem. Mol. Biol. (1998) 65:295-299.

Androgen-activating enzymes in the central nervous system.
Poletti A., Martini L.
J. Steroid Biochem. Mol. Biol. (1998) 69:117-122

Presence of androgen-activating enzyme in the human prostatic cancer cell line LNCaP and in Begnin prostatic hyperplasia.
Negri-Cesi P., Poletti A., Colciago A., Magni P., Martini P., Motta M.
The Prostate (1998) 34:283-291.

Transient expression of the type 2 5alpha-reductase isozyme in the brain of the late fetal and early post-natal life.
Poletti A., Negri-Cesi P., Rabuffetti M., Colciago A., Celotti F., Martini L.
Endocrinology.(1998) 139: 2171-2178.

Expression of androgen-activating enzymes in cultured cells of developing rat brain.
Poletti A., Negri-Cesi P., Melcangi R.C., Colciago A., Martini L., Celotti F.
J. Neurochem. (1997) 68:1298-1303.

Phosphorylation of human progesterone receptor by Cyclin-dependent kinase 2 on three sites that are authentic basal phosphorylation sites in vivo.
Zhang Y., Beck C.A., Poletti A., Clement IV J.P., Prendergast P., Yip T.-T., Hutchens T.W., Edwards D.P., Weigel N.L.
Mol. Endocrinol.(1997) 11:823-832.

Identification of type 1 5alpha-reductase in myelin membranes of male and female rat brain.
Poletti A., Celotti F., Rumio C., Rabuffetti M., Martini L.
Mol. Cell. Endocr.(1997) 129:181-190.

Steroid metabolism in the mammalian brain: 5alpha-reduction and aromatization.
Celotti F., Negri-Cesi P., Poletti A.
Brain Res.Bull. (1997) 44:365-375.

Characterisation of rat 5alpha-reductases type 1 and type 2 expressed in yeast Saccharomyces cerevisiae.
Poletti A., Celotti F., Motta M., Martini L.
Biochem. J. (1996) 314:1047-1052.

Synthesis of a chemiluminescent probe useful for the purification of steroid 5alpha-reductase
Guarna A., Poletti A., Catrambone F., Danza G., Marrucci A., Serio M., Celotti F., Martini L.
Bioorg. Med. Chem. Lett. (1996) 6:1997-2002.

Luteinizing hormone-releasing hormone (LHRH) agonists interfere with the stimulatory actions of the epidermal growth factor in human prostatic cancer cell lines, LNCaP and DU145.
Moretti R.M., Montagnani-Marelli M., Dondi D., Poletti A., Martini L., Motta M., Limonta P.
J. Clin. Endocr. Metab. (1996) 81:3930-3936.

Effect of suramin on the biological activity of the two isoforms of the rat 5alpha-reductase
Poletti A., Rabuffetti M., Martini L.
Steroids, (1996) 61: 504-505.

Metabolism of steroids in the brain: a new insight in the role of 5alpha-reductase and aromatase in the brain differentiation and functions.
Negri-Cesi P., Poletti A. and Celotti F.
J. Steroid Biochem. Mol. Biol. (1996) 58: 455-466.

Phosphorylation and progesterone receptor function.
Weigel N.L., Bai W., Zhang Y., Beck C.A., Edwards D.P., Poletti A.
J.Steroid Biochem. Mol. Biol. (1996) 53:1-6.

Identification of a group of Ser-Pro motif hormone inducible phosphorylation sites in human progesterone receptor.
Zhang Y., Beck C.A., Poletti A., Edwards D.P., Weigel N.L.
Mol.Endocrinol. (1995) 9:1029-1040.

Steroid binding and metabolism in the LHRH-producing neuronal cell line GT1-1.
Poletti A., Melcangi R.C., Negri-Cesi P., Maggi R., Martini L.
Endocrinology (1994) 135:2623-2628.

 Identification of phosphorylation sites unique to the B form of the human progesterone receptor: in vitro phosphorylation by Casein Kinase II.       
Zhang Y.,. Beck C.A, Poletti A., Edwards D.P., Weigel N.L.
J Biol Chem (1994) 269:31034-31040.

Identification of a Hormone-dependent phosphorylation site adjacent to the DNA binding domain of the chicken progesterone receptor.
Poletti A., Weigel N.L.
Mol Endocrinol (1993) 7, 241-246.

Chicken progesterone receptor expressed in Saccharomyces cerevisiae is correctly phosphorylated at all four Ser-Pro phosphorylation sites.
Poletti A., Conneely O.M., McDonnell D.P., Schrader W.T., O'Malley B.W., Weigel N.L.
Biochemistry (1993) 32,9563-9569

A novel, highly regulated, rapidly inducible system for the expression of chicken progesterone receptor, cPRa, in Saccharomyces cerevisiae.
Poletti A., Weigel N.L., McDonnell D.P., Schrader W.T. and O'Malley B.W.
Gene (1992) 114:51-58.

Kinetics properties of the 5alpha-reductase of testosterone in the purified myelin, in the sub-cortical white matter, and in the cerebral cortex of the male rat brain.
Poletti A., Celotti F., Melcangi R.C., Ballabio M., and Martini L.
J Steroid Biochem (1990) 35:97-101.

5alpha-reductase activity in isolated and cultured neuronal and glial cells of the rat.
Melcangi C., Celotti F., Ballabio M., Castano P., Massarelli R., Poletti A. and Martini L.
Brain Res (1990) 516:229-236.

Testosterone metabolism in peripheral nerves: presence of the 5alpha-reductase 3alpha-hydroxysteroid dehydro- genase enzymatic system in the sciatic nerve of adult and aged rats.
Melcangi R.C., Celotti F., Ballabio M., Poletti A., and Martini L.
J Steroid Biochem (1990) 35:145-148.

Effect of postnatal starvation on the 5alpha-reductase activity of the brain and of the isolated myelin membranes.
Melcangi R.C., Celotti F., Ballabio M., Carnaghi R., Poletti A. and Martini L.
Exp Clin Endocrinol Diab (1989) 94:253-261.

Testosterone 5alpha-reductase activity in the rat brain is highly concentrated in white matter structures and in purified myelin sheaths of axons.
Melcangi R.C., Celotti F., Ballabio M., Poletti A., Castano P., and Martini L.
J Steroid Biochem (1988) 31:173-179.

Ontogenetic development of the 5alpha-reductase in the rat brain: cerebral cortex, hypothalamus, purified myelin and isolated oligodendrocytes.
Melcangi R.C., Celotti F., Ballabio M., Castano P., Poletti A., Milani S. and Martini L.
Dev Brain Res (1988) 44:181-188.

The 5alpha-reductase activity of the subcortical white matter, the cerebral cortex and the hypothalamus of the rat and the mouse: possible sex differences and effect of castration.
Melcangi R.C., Celotti F., Poletti A., Negri-Cesi P. and Martini L.
Steroids (1987) 49:259.