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Publications

2017

  • FRET studies of various conformational states adopted by transthyretin. Ghadami SA, Bemporad F, Sala BM, Tiana G, Ricagno S., Chiti F. Cell Mol Life Sci. 2017 May 6. doi: 10.1007/s00018-017-2533-x.

  • An Asp to Asn mutation is a toxic trigger in beta-2 microglobulin: structure and biophysics. de Rosa M, Halabelian L, Barbiroli A, Bolognesi M, Bellotti V, Ricagno S. Amyloid. 2017 Mar;24(sup1):15-16. doi: 10.1080/13506129.2016.1272450.

2016

  • Molecular basis of a novel renal amyloidosis due to N184K gelsolin variant.Bon� F, Milani M, Porcari R, Barbiroli A, Ricagno S., de Rosa M. Sci Rep. 2016 Sep 16;6:33463. doi: 10.1038/srep33463.

  • Tools for the rational design of bivalent microtubule-targeting drugs. Marangon J, Christodoulou MS, Casagrande FV, Tiana G, Dalla Via L, Aliverti A, Passarella D, Cappelletti G, Ricagno S.
    Biochem Biophys Res Commun. 2016 Sep 7. doi: 10.1016/j.bbrc.2016.09.022.

  • Rational design of mutations that change the aggregation rate of a protein while maintaining its native structure and stability.
    Camilloni C, Sala BM, Sormanni P, Porcari R, Corazza A, De Rosa M, Zanini S, Barbiroli A, Esposito G, Bolognesi M, Bellotti V, Vendruscolo M, Ricagno S.
    Sci Rep. 2016 May 6;6:25559. doi: 10.1038/srep25559.

  • Embelin binds to human neuroserpin and impairs its polymerisation.
    Saga G, Sessa F, Barbiroli A, Santambrogio C, Russo R, Sala M, Raccosta S, Martorana V, Caccia S, Noto R, Moriconi C, Miranda E, Grandori R, Manno M, Bolognesi M, Ricagno S.
    Sci Rep. 2016 Jan 6;6:18769. doi: 10.1038/srep18769.

2015

  • Decoding the Structural Bases of D76N �2-Microglobulin High Amyloidogenicity through Crystallography and Asn-Scan Mutagenesis.
    de Rosa M, Barbiroli A, Giorgetti S, Mangione PP, Bolognesi M, Ricagno S.
    PLoS One. 2015 Dec 1;10(12):e0144061. doi: 10.1371/journal.pone.0144061. eCollection 2015.

  • A covalent homodimer probing early oligomers along amyloid aggregation.
    Halabelian L, Relini A, Barbiroli A, Penco A, Bolognesi M, Ricagno S.
    Sci Rep. 2015 Sep 30;5:14651. doi: 10.1038/srep14651.

  • Wild type beta-2 microglobulin and DE loop mutants display a common fibrillar architecture.
    Natalello A, Relini A, Penco A, Halabelian L, Bolognesi M, Doglia SM, Ricagno S.
    PLoS One. 2015 Mar 24;10(3):e0122449. doi: 10.1371/journal.pone.0122449.

  • Functional and dysfunctional conformers of human neuroserpin characterized by optical spectroscopies and Molecular Dynamics.
    Noto R, Santangelo MG, Levantino M, Cupane A, Mangione MR, Parisi D, Ricagno S, Bolognesi M, Manno M, Martorana V.
    Biochim Biophys Acta. 2014 Nov 6;1854(2):110-117.

2014

  • Rapid proton-detected NMR assignment for proteins with fast magic angle spinning.
    Barbet-Massin E, Pell AJ, Retel JS, Andreas LB, Jaudzems K, Franks WT, Nieuwkoop AJ, Hiller M, Higman V, Guerry P, Bertarello A, Knight MJ, Felletti M, Le Marchand T, Kotelovica S, Akopjana I, Tars K, Stoppini M, Bellotti V, Bolognesi M, Ricagno S, Chou JJ, Griffin RG, Oschkinat H, Lesage A, Emsley L, Herrmann T, Pintacuda G.
    J Am Chem Soc. 2014 Sep 3;136(35):12489-97.

  • Class I Major Histocompatibility Complex, the Trojan Horse for Secretion of Amyloidogenic β2-Microglobulin. Halabelian L*, Ricagno S*, Giorgetti S*, Santambrogio C, Barbiroli A, Pellegrino S, Achour A, Grandori R, Marchese L, Raimondi S, Mangione PP, Esposito G, Al-Shawi R, Simons JP, Speck I, Stoppini M, Bolognesi M, Bellotti V. J Biol Chem. 2014 Feb 7;289(6):3318-27.

    * These authors contributed equally to this work

  • Edge strand engineering prevents native-like aggregation in Sulfolobus solfataricus acylphosphatase. de Rosa M, Bemporad F, Pellegrino S, Chiti F, Bolognesi M, Ricagno S*. FEBS J. 2014 Jun 3

2012

2011

  • Characterization of β2-microglobulin conformational intermediates associated to different fibrillation conditions. Santambrogio C, Ricagno S, Sobott F, Colombo M, Bolognesi M, Grandori R. J Mass Spectrom. 2011 Aug;46(8):734-41.

  • The two tryptophans of β2-microglobulin have distinct roles in function and folding and might represent two independent responses to evolutionary pressure. Raimondi S, Barbarini N, Mangione P, Esposito G, Ricagno S, Bolognesi M, Zorzoli I, Marchese L, Soria C, Bellazzi R, Monti M, Stoppini M, Stefanelli M, Magni P, Bellotti V. BMC Evol Biol. 2011 Jun 10;11:159.

  • D-strand perturbation and amyloid propensity in beta-2 microglobulin. Azinas S, Colombo M, Barbiroli A, Santambrogio C, Giorgetti S, Raimondi S, Bonomi F, Grandori R, Bellotti V, Ricagno S, Bolognesi M. FEBS J. 2011 Jul;278(13):2349-58.

  • The effects of an ideal beta-turn on beta-2 microglobulin fold stability. Colombo M, Ricagno S, Barbiroli A, Santambrogio C, Giorgetti S, Raimondi S, Bonomi F, Grandori R, Bellotti V, Bolognesi M. J Biochem. 2011 Jul;150(1):39-47.

2010

2009

  • CtBP1/BARS Gly172-->Glu mutant structure: impairing NAD(H)-binding and dimerization. Nardini M, Valente C, Ricagno S, Luini A, Corda D, Bolognesi M. Biochem Biophys Res Commun. 2009 Mar 27;381(1):70-4.

  • Human beta-2 microglobulin W60V mutant structure: Implications for stability and amyloid aggregation. Ricagno S, Raimondi S, Giorgetti S, Bellotti V, Bolognesi M. Biochem Biophys Res Commun. 2009 Mar 13;380(3):543-7.

  • Human neuroserpin: structure and time-dependent inhibition. Ricagno S, Caccia S, Sorrentino G, Antonini G, Bolognesi M. J Mol Biol. 2009 Apr 24;388(1):109-21.

  • Recognition of RNA cap in the Wesselsbron virus NS5 methyltransferase domain: implications for RNA-capping mechanisms in Flavivirus. Bollati M, Milani M, Mastrangelo E, Ricagno S, Tedeschi G, Nonnis S, Decroly E, Selisko B, de Lamballerie X, Coutard B, Canard B, Bolognesi M. J Mol Biol. 2009 Jan 9;385(1):140-52.

2008

2007

  • The crystal structure of FdxA, a 7Fe ferredoxin from Mycobacterium smegmatis. Ricagno S, de Rosa M, Aliverti A, Zanetti G, Bolognesi M. Biochem Biophys Res Commun. 2007 Aug 17;360(1):97-102.

  • De novo initiation of RNA synthesis by the arterivirus RNA-dependent RNA polymerase. Beerens N, Selisko B, Ricagno S, Imbert I, van der Zanden L, Snijder EJ, Canard B. J Virol. 2007 Aug;81(16):8384-95.

2006

  • Crystal structure of the receptor-binding protein head domain from Lactococcus lactis phage bIL170. Ricagno S, Campanacci V, Blangy S, Spinelli S, Tremblay D, Moineau S, Tegoni M, Cambillau C. J Virol. 2006 Sep;80(18):9331-5.

  • Crystal structure and mechanistic determinants of SARS coronavirus nonstructural protein 15 define an endoribonuclease family. Ricagno S, Egloff MP, Ulferts R, Coutard B, Nurizzo D, Campanacci V, Cambillau C, Ziebuhr J, Canard B. Proc Natl Acad Sci U S A. 2006 Aug 8;103(32):11892-7.

  • Crystallization and preliminary X-ray diffraction analysis of Nsp15 from SARS coronavirus. Ricagno S, Coutard B, Grisel S, Br�mond N, Dalle K, Tocque F, Campanacci V, Lichi�re J, Lantez V, Debarnot C, Cambillau C, Canard B, Egloff MP. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Apr 1;62(Pt 4):409-11.

  • Detection and characterization of merohedral twinning in crystals of oxalyl-coenzyme A decarboxylase from Oxalobacter formigenes. Berthold CL, Sidhu H, Ricagno S, Richards NG, Lindqvist Y. Biochim Biophys Acta. 2006 Jan;1764(1):122-8.

2005

  • The enzymes of oxalate metabolism: unexpected structures and mechanisms. Svedruzić D, J�nsson S, Toyota CG, Reinhardt LA, Ricagno S, Lindqvist Y, Richards NG. Arch Biochem Biophys. 2005 Jan 1;433(1):176-92. Review.

2004

  • Kinetic and mechanistic characterization of the formyl-CoA transferase from Oxalobacter formigenes. Jonsson S*, Ricagno S*, Lindqvist Y, Richards NG. J Biol Chem. 2004 Aug 20;279(34):36003-12.  (* These authors contributed equally to this work).

  • Crystal structure of 1-deoxy-d-xylulose-5-phosphate reductoisomerase from Zymomonas mobilis at 1.9-A resolution. Ricagno S, Grolle S, Bringer-Meyer S, Sahm H, Lindqvist Y, Schneider G. Biochim Biophys Acta. 2004 Apr 8;1698(1):37-44.

2003

  • Formyl-CoA transferase encloses the CoA binding site at the interface of an interlocked dimer. Ricagno S, Jonsson S, Richards N, Lindqvist Y. EMBO J. 2003 Jul 1;22(13):3210-9.

  • Crystallization and preliminary crystallographic analysis of formyl-CoA tranferase from Oxalobacter formigenes. Ricagno S, Jonsson S, Richards N, Lindqvist Y. Acta Crystallogr D Biol Crystallogr. 2003 Jul;59(Pt 7):1276-7.

  • Crystal structure of thiamindiphosphate-dependent indolepyruvate decarboxylase from Enterobacter cloacae, an enzyme involved in the biosynthesis of the plant hormone indole-3-acetic acid. Sch�tz A, Sandalova T, Ricagno S, H�bner G, K�nig S, Schneider G. Eur J Biochem. 2003 May;270(10):2312-21.

2002

  • Crystal structure of the productive ternary complex of dihydropyrimidine dehydrogenase with NADPH and 5-iodouracil. Implications for mechanism of inhibition and electron transfer. Dobritzsch D, Ricagno S, Schneider G, Schnackerz KD, Lindqvist Y. J Biol Chem. 2002 Apr 12;277(15):13155-66.

2000

  • DcE2F, a functional plant E2F-like transcriptional activator from Daucus carota. Albani D, Mariconti L, Ricagno S, Pitto L, Moroni C, Helin K, Cella R. J Biol Chem. 2000 Jun 23;275(25):19258-67.