Ongoing and Past Projects
Project
title:
Carcinogen induced Epigenetic Switching in Human Retroelements: a
Mechanistic Study on Benzene Effects
Year: 02/01/2013 - 31/12/2015
Funding: AIRC
(Italian Association for Research against Cancer) IG 13383
Principal
Investigator: Prof. Silvia Fustinoni
Participants:
University of Milan; University of Insubria, University of Parma
Topics:
Epigenetic modification in vitro and in humans following benzene
exposure.
Project title:
A prospective open-label Phase-2 study of metopyrone as a preoperative
treatment in patients with ACTH-independent Cushing's syndrome due to
adrenal adenoma.
Year: 2014 - 2016
Funding:
Internal Medicine I, San Luigi Hospital Orbassano (TO)
Principal Investigator: Prof. Massimo Terzolo
Participants: University of Milano; IRCCS Fondazione Ca'
Granda Ospedale
Maggiore Policlinico Milano; A.O. Città della Salute e della Scienza,
Torino; A.O. di Padova; A.O. Universitaria Careggi, Firenze; Ospedale
Umberto I, Ancona; Università Federico II, Napoli; A.O. Sant'Andrea La
Sapienza, Roma; A.S.O. Santa Croce e Carle, Cuneo
Topics: to study
metopyrone as a preoperative treatment in patients with ACTH-independent
Cushing's syndrome due to adrenal adenoma.
Project title:
SPHERE.
Susceptibility to Particle Health Effects, miRNAs and Exosomes
Year: 2011-2016
Funding:
European Union (Seventh Framework Programme), European Research Council
(ERC) Starting Grant (ERC-2011-StG 282413)
Principal
Investigator: Prof. Valentina Bollati
Participants:
University of Milan
Topics: to
explore extracellular vesicles (EVs) and their miRNA as a novel
potential mechanism of how air pollution exposure acts in a highly
susceptible population
Website:
http://users.unimi.it/sphere
Publications: Bollati et al., 2014
Year:
2012-2014
Funding:
Provincia di Modena
Principal Investigator: Dr. Carlo Goldoni
Participants: AUSL Modena, ARPA Emila Romagna, University of Milan,
Topics:
Sorveglianza
epidemiologica su un campione di soggetti residenti nell'area di
ricaduta degli inquinanti provenienti dall'impianto di incenerimento di
rifiuti urbani per la definizione di caratteristiche individuali, stili
di vita e stato di salute attraverso un'intervista diretta e la ricerca
di biomarcatori di esposizione.
(Health Surveillance and biomonitoring of a cohort of subjects living in
the vicinity of an urban solid-waste incinerator)
Website:
www.ausl.mo.it
Project title:
ACROPOLIS.
Aggregate and Cumulative Risk Of Pesticides: an On-Line integrated
strategy
Year: 2009-2013
Funding: European Commission's Seventh Framework Programme (FP7)
(EU-FP7 KBBE-2009 No. 245163)
Principal
Investigator: Prof. Jacob van Klaveren
Participants:
National Institute for Public Health and the Environment, The
Netherlands; The Food and Environment Research Agency, UK; University of
Milano, Italy; National Research Institute for Food and Nutrition
(INRAN), Italy; Institute for Risk Assessment Sciences - Utrecht
University, The Netherlands; Health and Safety Executive - Chemicals
Regulation Directorate, UK; National Institute of Public Health, Czech
Republic; Freshfel Europe, Belgium; National Food Agency, Sweden; Ghent
University, Belgium; Wageningen University and Research Centre, The
Netherlands; Austrian Agency for Health and Food Safety (AGES), Austria;
State General Laboratory, Ministry of Health, Cyprus; French Agency for
Food, Environmental and Occupational Health & Safety (ANSES); France;
National Institute of Public Health, Slovenia; Technical University of
Denmark, Denmark; Benaki Phytopathological Institute, Greece; Food and
Veterinary Service, Latvia
Topics: The
project aims to develop a framework for cumulative and aggregate risk
assessment of pesticides that is scientifically sound and accessible for
all actors involved in the European risk assessment and risk management.
Website:
www.acropolis-eu.com
Publications: Mercadante, et al., 2014, Fustinoni et al., 2014, Kennedy
et al., 2014 accepted
Project
title: MONITER.
Organizzazione di un sistema di sorveglianza ambientale e valutazione
epidemiologica nelle aree circostanti gli impianti di incenerimento in
Emilia-Romagna) (Environmental monitoring and epidemiological
surveillance in the population living near urban solid waste
incinerators in Emila Romagna region)
Year:
2007-2009
Funding:
ARPA Emilia Romagna, Emilia Romagna region,
Principal Investigator: Dr. Paolo Lauriola
Participants: ARPA Emila Romagna, University of Milan, AUSL Modena
Topics:
Environmental monitoring and epidemiological surveillance in the
population living near urban solid waste incinerators in Emila Romagna
region
Website:
www.arpa.emr.it
Publications: Ranzi et al., 2013; Fustinoni et al., 2013a
Project
title:
PM-CARE
Studio dei meccanismi patogenetici degli effetti cardiorespiratori
prodotti dall'inquinamento urbano da particolato (Study of the
mechanisms of cardio respiratory effects induced by particles of urban
air pollution)
Year:
2004-2006
Funding:
Ministero Istruzione, Università
e Ricerca (MIUR-PRIN prot. 2004062580)
Principal investigator: Prof. M. Maroni
Participants: Università degli Studi di Milano; Università
dell'Insubria; Università di Milano-Bicocca; Politecnico di Milano;
Università di Catanzaro
Topics: General
objective of the project is to determine the mechanisms through which
urban air particles worsen cardiovascular and respiratory diseases
Project
title:
Interazione ambiente-genoma: polimorfismi genetici e suscettibilità
individuale a inquinanti chimici occupazionali ed ambientali (Genetic
polymorphism and individual susceptibility to occupational and
environmental exposure to toxic chemicals)
Year:
2003-2005
Funding:
Ministero Istruzione, dell'
Università e
Ricerca
(MIUR-PRIN
prot. 2003065175)
Principal Investigator: Prof. P.A. Bertazzi
Participants: Università degli Studi di Milano; Università di Bari;
Università di Genova; University of Cagliari; Università di Padova
Topics: to study
the interaction between genetic polymorphism and individual
susceptibility to occupational and environmental exposure to toxic
chemicals)
Publications: Rossella 2009a, Campo 2010, Campo et al., 2012, Fustinoni
et al., 2012a; Fustinoni et al., 2012b; Campo, 2012;
Carugno et al., 2012; Zhu et al, 2012; Campagna et al., 2012;
Campo et al., 2014; Campagna, 2014.
Project
title:
PPTP.
Progetto prevenzione tumori professionali della regione Lombardia
(Occupational Cancer Prevention)
Year:
2004-2006
Funding:
Regione Lombardia (DRG
VII/18344 del 23.07.2004)
Principal Investigator: Prof. P.A. Bertazzi
Participants: Università degli Studi di Milano
Topics: to study
the occupational exposure to carcinogens in Lombardy Region
Publications: Campo, 2006a; Campo et al,
2006b; Cirla et al., 2007a; Cirla et al., 2007b; Cirla et al., 2007c;
Buratti et al., 2007a; Buratti et al., 2007b; Campo et al, 2007;
Fustinoni et al., 2007b; Campo et al., 2008b.
Project
title:
Nuovi indicatori per il monitoraggio biologico dell'esposizione a
idrocarburi policiclici aromatici (New biomarkers for the assessment of
exposure to polycyclic aromatic hydrocarbons)
Year:
2004-2005
Funding:
Istituto superiore per la prevenzione e sicurezza dei lavoratori
(Contratto
B/47/MDL/03)
Principal investigator: Prof. Vito Foà
Participants: Università degli studi di Milano
Topics: to study
new biomarkers for the assessment of exposure to polycyclic aromatic
hydrocarbons alternative to 1-hydroxypyrene
Publications: Campo, 2006a; Campo et al,
2006b; Cirla et al., 2007; Buratti et al., 2007a; Campo et al, 2007;
Buratti et al., 2007b; Campo et al., 2009;
Project title: EUROPIT.
Toxicological evaluation of the immune function of pesticide workers, an
European wide assessment.
Year: 2001-2005
Funding:
European Commission's fifth Framework Programme (FP5) (QLRT-2001-00211)
Participants:
University of Milan, Italy; Istituto di Ricerche Farmacologiche ‘Mario
Negri', Italy; International Centre for Pesticides and Health Risk
Prevention, Italy; Maastricht University, the Netherlands; Finnish
Institute of Occupational Health, Finland; University of Turku, Finland;
National Centre of Public Health Protection, Bulgaria; National
Institute of Public Health and the Environment, the Netherlands.
Topics: to
assess the immunotoxic potential of selected pesticides in
occupationally exposed workers
Publications: Corsini et., 2005; Colosio et al, 2006; Colosio et al.,
2007; Fustinoni et al., 2008b; van Amelsvoort et al., 2008; Steerenberg
et al., 2008; Baranska et al., 2008; Swaen et al., 2008; Boers et al.,
2008.
Project title: BIOMED.
Exposure to low levels of benzene, interindividual biological
variability and cancer risk: a multicentre European study
Year: 1998-2001
Funding:
European Union (BIOMED2, contract BMH4-CT98-3785)
Participants:
University of Milan, Italy; University of Medicine and Dentistry of New
Jersey, New Jersey; University of Leicester, United Kingdom; National
Cancer Research Institute, Genova, Italy; National Centre of Public
Health and Analyses, Sofia, Bulgaria
Topics: to study
the exposure to low levels of benzene together with the interindividual
biological variability and the cancer risk.
Publications: Fustinoni et al., 2005c; Fustinoni et al., 2005d; Farmer
et al., 2005; Bollati et al., 2007; Fustinoni et al., 2010d; Carugno et
al., 2012; Zhu et al, 2012; Fustinoni et al., 2012b.
Project
title:
Strategie di controllo del rischio da cancerogeni chimici occupazionali:
sviluppo di indicatori di esposizione, dosi ed effetti.
Monitoraggio biologico di cancerogeni attivi dopo la formazione di
epossidi (Biological monitoring of carcinogens activated by the epoxide
biotraformation)
Year:
2001
Funding:
ISPESL (Istituto superiore per la prevenzione e sicurezza dei
lavoratori, National Institute for workers' health prevention and
safety) (Contratto 2001PMS/19/01 U05) e Ministero Sanità
(Health Minister)
Principal Investigator: Prof. Vito Foà
Participants: University of Milan;
Topics: Several
chemicals classified as carcinogens for humans, once inhaled and
adsorbed, are metabolized to epoxides, genotoxic species thought to be
responsible for the carcinogenic activity. Aim of the project is to
investigate occupational exposure to some of these chemicals.
Publications: Fustinoni et al., 2004; Fustinoni et al., 2005c; Fustinoni
et al., 2005d; Lovreglio et al, 2006;
Primavera et al.
2008; Fustinoni et al.,
2008a; Bukvic et al., 2009; Fustinoni et al., 2010a.
Project
title:
Individuazione di indicatori biologici urinari per il monitoraggio
dell'esposizione a tetrafluoroetilene (TFE) (Urinary biomarker for the
assessment of the exposure to tetrefluoroethylene)
Year:
2001
Funding:
Istituto superiore per la prevenzione e sicurezza dei lavoratori
(Contratto
B/42/MDL/01)
Principal investigator: prof. Silvia Fustinoni
Participants: Università degli Studi di Milano; Consorzio per il CC/WHO
ICP/ISPESL
Topics: to
develop analytical method for the quantification of urinary biomarkers
of exposure to tetrafluoroethylene
Publications: Campo et al., 2003.
Project
title:
Sviluppo di indicatori di dose interna per esposizione professionale a
butadiene (Biomarkers of internal dose of occupational exposure to
1,3-butadiene)
Year:
2000
Principal Investigator: Vito Foà
Participants: Università degli Studi di Milano
Funding:
Istituto superiore per la prevenzione e sicurezza dei lavoratori
(Contratto
B/58/MDL/00)
Topics: to
investigate the occupational exposure to 1,3-butadiene by environmental
and biological monitoring
Publications: Begemann et al.,2001; Fustinoni et al., 2002; Fustinoni et
al., 2004; Lovreglio et al., 2006; Primavera et al., 2008; Bukvic et
al., 2009.
Project
title:
Esposizione a 1,3-butadiene nell'inquinamento urbano e negli ambienti di
lavoro: ricerca di indicatori biologici di dose, di effetto e di
suscettibilità
Year:
2000
Funding:
Ministero Istruzione,
Ricerca e Università
(COFIN,
contract
B/58/DML/00)
Participants:
University of Milan, University of Bari, University of Verona,
University of Naples, University of Padua
Topics:
Biomonitoring of the occupational exposure to 1,3-butadiene and the
influence of single nucleotide polymorphisms of metabolic enzymes.
Publications: Fustinoni et al., 2004; Lovreglio et al., 2006; Primavera
et al., 2008; Bukvic et al., 2009.
Project title:
The role of host, genetic and environmental factors on biochemical
markers in workers exposed to butadiene
Year: 1996-2000
Funding:
European Union (BMH4-CT96-1640)
Participants:
University of Milan, University of Bari, Karolinska Institutet and
National Institute for
Working Life,
Stockholm, Sweden , University of Würzburg, Germany, University of Padua
Topics:
Biomonitoring of the occupational exposure to 1,3-butadiene and the
influence of single nucleotide polymorphisms of metabolic enzymes.
Publications:
Begemann et al.,2001; Fustinoni et al., 2002.
Project
title:
Gli indicatori biologici di esposizione professionale a benzene
attualmente utilizzati: correlazione con il monitoraggio ambientale,
confronto tra i risultati ed individuazione di un criterio di scelta
Year:
2000
Funding:
Istituto superiore per la prevenzione e sicurezza dei lavoratori e
Ministero Sanità (Contratto
B/46/DIL/00)
Principal
investigator: Vito Foà
Participants:
University of Milan
Topics:
Biomarkers of low benzene exposure
Publications: Fustinoni al., 1999; Perbellini 1999; Buratti 2001;
Waidyanatha et al., 2001.