Categoria: Peptidomimetics

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beta-Hairpin mimics containing a piperidine– pyrrolidine scaffold modulate the beta-amyloid aggregation process preserving the monomer species

Chem. Sci., 2017, 8, 1295–1302 DOI: 10.1039/C6SC03176E Alzheimer’s disease is a neurodegenerative disorder linked to oligomerization and fibrillization of amyloid b peptides, with Ab1–42 being the most aggregative and neurotoxic one. We report herein...

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Model peptides containing the 3-sulfanylnorbornene

The properties of the constrained tetrasubstituted 3-sulfanylnorbornene amino acid (NRB), when inserted in Ala-Aib model peptides, were extensively studied. The conformational behaviour of these models was evaluated by theoretical calculations, spectroscopic analyses and by...