2020

 

An (R)-Selective Transaminase From Thermomyces stellatus: Stabilizing the Tetrameric Form. Heckmann CM, Gourlay LJ, Dominguez B, Paradisi F. Front Bioeng Biotechnol. 2020 Jul 22;8:707. doi: 10.3389/fbioe.2020.00707. eCollection 2020. PMID: 32793563

 

Conformational Stability and Dynamics in Crystals Recapitulate Protein Behavior in Solution. Sala BM, Le Marchand T, Pintacuda G, Camilloni C, Natalello A, Ricagno S. Biophys J. 2020 Sep 1;119(5):978-988. doi: 10.1016/j.bpj.2020.07.015. Epub 2020 Jul 24. PMID: 32758421

 

Detecting the nature and solving the crystal structure of a contaminant protein from an opportunistic pathogen. Pederzoli R, Tarantino D, Gourlay LJ, Chaves-Sanjuan A, Bolognesi M. Acta Crystallogr F Struct Biol Commun. 2020 Sep 1;76(Pt 9):392-397. doi: 10.1107/S2053230X20010626. Epub 2020 Aug 28. PMID: 32880586

 

Embelin as Lead Compound for New Neuroserpin Polymerization Inhibitors. Visentin C, Musso L, Broggini L, Bonato F, Russo R, Moriconi C, Bolognesi M, Miranda E, Dallavalle S, Passarella D, Ricagno S. Life (Basel). 2020 Jul 11;10(7):111. doi: 10.3390/life10070111. PMID: 32664592

 

 

Glycosylation Tunes Neuroserpin Physiological and Pathological Properties. Visentin C, Broggini L, Sala BM, Russo R, Barbiroli A, Santambrogio C, Nonnis S, Dubnovitsky A, Bolognesi M, Miranda E, Achour A, Ricagno S. Int J Mol Sci. 2020 May 3;21(9):3235. doi: 10.3390/ijms21093235. PMID: 32375228

 

Two novel fish paralogs provide insights into the Rid family of imine deaminases active in pre-empting enamine/imine metabolic damage. Digiovanni S, Visentin C, Degani G, Barbiroli A, Chiara M, Regazzoni L, Di Pisa F, Borchert AJ, Downs DM, Ricagno S, Vanoni MA, Popolo L. Sci Rep. 2020 Jun 23;10(1):10135. doi: 10.1038/s41598-020-66663-w. PMID: 32576850

 

Functionally Divergent Splicing Variants of the Rice AGAMOUS Ortholog OsMADS3 Are Evolutionary Conserved in Grasses. Dreni L, Ravasio A, Gonzalez-Schain N, Jacchia S, da Silva GJ, Ricagno S, Russo R, Caselli F, Gregis V, Kater MM. Front Plant Sci. 2020 May 25;11:637. doi: 10.3389/fpls.2020.00637. eCollection 2020. PMID: 32523596

 

Glycosylation Tunes Neuroserpin Physiological and Pathological Properties. Visentin C, Broggini L, Sala BM, Russo R, Barbiroli A, Santambrogio C, Nonnis S, Dubnovitsky A, Bolognesi M, Miranda E, Achour A, Ricagno S. Int J Mol Sci. 2020 May 3;21(9):3235. doi: 10.3390/ijms21093235. PMID: 32375228

 

The co-existence of cold activity and thermal stability in an Antarctic GH42 β-galactosidase relies on its hexametric quaternary arrangement. Mangiagalli M, Lapi M, Maione S, Orlando M, Brocca S, Pesce A, Barbiroli A, Camilloni C, Pucciarelli S, Lotti M, Nardini M. FEBS J. 2020 May 4. doi: 10.1111/febs.15354. [Epub ahead of print]

 

Mycobacterial and human nitrobindins: structure and function. De Simone G, di Masi A, Vita GM, Polticelli F, Pesce A, Nardini M, Bolognesi M, Ciaccio C, Coletta M, Turilli ES, Fasano M, Tognaccini L, Smulevich G, Abbruzzetti S, Viappiani C, Bruno S, Ascenzi P. Antioxid Redox Signal. 2020 Apr 16. doi: 10.1089/ars.2019.7874. [Epub ahead of print] PMID: 32295384

 

Determination of Protein Structural Ensembles by Hybrid-Resolution SAXS Restrained Molecular Dynamics. Paissoni C, Jussupow A, Camilloni C. J Chem Theory Comput. 2020 Mar 11. doi: 10.1021/acs.jctc.9b01181. [Epub ahead of print] PMID: 32119546

 

Comprehensive response to Usutu virus following first isolation in blood donors in the Friuli Venezia Giulia Region of Italy: Development of recombinant NS1-based serology and sensitivity to antiviral drugs. Caracciolo I, Mora Cardenas E, Aloise C, Carletti T, Segat L, Burali MS, Chiarvesio A, Totis V, Avcic-Zupanc T, Mastrangelo E, Manfroni G, D'Agaro P, Marcello A. PLoS Negl Trop Dis. 2020 Mar 30;14(3):e0008156. [Epub ahead of print] PMID: 32226028

 

Functional and structural analysis of trehalose-6-phosphate phosphatase from Burkholderia pseudomallei: Insights into the catalytic mechanism. Suthisawat S, Gourlay LJ, Bolognesi M, Boonyuen U, Vanaporn M. Biochem Biophys Res Commun. 2020 Mar 19;523(4):979-984. doi: 10.1016/j.bbrc.2019.12.088. Epub 2020 Jan 20. PMID: 31973820

 

Evaluation of sofosbuvir activity and resistance profile against West Nile virus in vitro. Dragoni F, Boccuto A, Picarazzi F, Giannini A, Giammarino F, Saladini F, Mori M, Mastrangelo E, Zazzi M, Vicenti I. Antiviral Res. 2020 Mar;175:104708. doi: 10.1016/j.antiviral.2020.104708. Epub 2020 Jan 10. PMID: 31931104

 

Biochemical and biophysical comparison of human and mouse beta-2 microglobulin reveals the molecular determinants of low amyloid propensity. Achour A, Broggini L, Han X, Sun R, Santambrogio C, Buratto J, Visentin C, Barbiroli A, De Luca CMG, Sormanni P, Moda F, De Simone A, Sandalova T, Grandori R, Camilloni C, Ricagno S. FEBS J. 2020 Feb;287(3):546-560. doi: 10.1111/febs.15046. Epub 2019 Aug 28.  PMID: 31420997

 

Structural Insight into IAPP-Derived Amyloid Inhibitors and Their Mechanism of Action. Niu Z, Prade E, Malideli E, Hille K, Jussupow A, Mideksa YG, Yan LM, Qian C, Fleisch M, Messias AC, Sarkar R, Sattler M, Lamb DC, Feige MJ, Camilloni C, Kapurniotu A, Reif B. Angew Chem Int Ed Engl. 2020 Mar 27;59(14):5771-5781. doi: 10.1002/anie.201914559. Epub 2020 Jan 28. PMID: 31863711

 

Structure and kinetic properties of human D-aspartate oxidase, the enzyme-controlling d-aspartate levels in brain. Molla G, Chaves-Sanjuan A, Savinelli A, Nardini M, Pollegioni L.  FASEB J. 2020 Jan;34(1):1182-1197.

 

Inherent Biophysical Properties Modulate the Toxicity of Soluble Amyloidogenic Light Chains. Maritan M, Romeo M, Oberti L, Sormanni P, Tasaki M, Russo R, Ambrosetti A, Motta P, Rognoni P, Mazzini G, Barbiroli A, Palladini G, Vendruscolo M, Diomede L, Bolognesi M, Merlini G, Lavatelli F, Ricagno S. J Mol Biol. 2020 Feb 14;432(4):845-860. doi: 10.1016/j.jmb.2019.12.015. Epub 2019 Dec 24. PMID: 31874151

 

The structural bases for agonist diversity in an Arabidopsis thaliana glutamate receptor-like channel. Alfieri A, Doccula FG, Pederzoli R, Grenzi M, Bonza MC, Luoni L, Candeo A, Romano Armada N, Barbiroli A, Valentini G, Schneider TR, Bassi A, Bolognesi M, Nardini M, Costa A. Proc Natl Acad Sci U S A. 2019 Dec 23. pii: 201905142.

 

The structure of N184K amyloidogenic variant of gelsolin highlights the role of the H-bond network for protein stability and aggregation properties. de Rosa M, Barbiroli A, Boni F, Scalone E, Mattioni D, Vanoni MA, Patrone M, Bollati M, Mastrangelo E, Giorgino T, Milani M. Eur Biophys J. 2020 Jan;49(1):11-19. doi: 10.1007/s00249-019-01409-9. Epub 2019 Nov 13. PMID: 31724080

 

Structural and functional characterization of the globin-coupled sensors of Azotobacter vinelandii and Bordetella pertussis. Germani F, Nardini M, De Schutter A, Cuypers B, Berghmans H, Van Hauwaert ML, Bruno S, Mozzarelli A, Moens L, Van Doorslaer S, Bolognesi M, Pesce A, Dewilde S.  Antioxid Redox Signal. 2020 Feb 20;32(6):378-395.

 

Evaluation of sofosbuvir activity and resistance profile against West Nile virus in vitro. Dragoni F, Boccuto A, Picarazzi F, Giannini A, Giammarino F, Saladini F, Mori M, Mastrangelo E, Zazzi M, Vicenti I. Antiviral Res. 2020 Jan 10:104708. doi: 10.1016/j.antiviral.2020.104708. [Epub ahead of print] PMID: 31931104

 

 

 

 

 

 

 

Publications

Last update 09/09/20

The Structural Biology Group comprises members from both the DBS-UNIMI and the IBF-CNR. The content herein is not regulated by the University of Milan.