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Angelo PolettiDipartimento di Scienze Farmacologiche e Biomolecolari
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He received his Italian Laurea [5 years (FT) = Bachelor's Degree + BSc programs] in Chemical and Pharmaceutical Technology (1984), a Master degree [3 years (FT) = MSc/MRes program] in Experimental Endocrinology (1987) and a Ph.D. [4 years (FT) program] degree in Endocrinological Sciences (1993) at the University of Milan, Italy. He spent a period of three years (1990-1992), at the Department of Cell Biology, Baylor College of Medicine, Houston, TX, USA, directect by Prof. Bert W. O'Malley, working under his supervision and with Nancy L. Weigel and William T. Schrader.
He is now working at the Dipartimento di Scienze Farmacologiche e Biomolecolari (DiSFeB) and Centre of Excellence on Neurodegenerative Diseases, where he directs the reserach laboratory of Experimental Biology and he also teaches 'Experimental Biology' and 'Cell Biology' at the Università degli Studi di Milano, Italy.
Current address:
Angelo Poletti Ph.D.
Dipartimento di Scienze Farmacologiche e Biomolecolari (DiSFeB)
Centre of Excellence on Neurodegenerative Diseases
Università degli Studi di Milano
via Balzaretti 9, 20133, Milano - ITALY
ph. (off.) +39-02-5031.8215 / (lab.) +39-02-5031.8227
fax +39-02-5031.8204
Researcher unique identifier: http://orcid.org/0000-0002-8883-0468
ORCID ID: 0000-0002-8883-0468
Researcher ID/Publons: A-9016-2011
Scopus Author ID: 7006039454
Loop profile: 107809
ALS Ice bucket challenge - Lab. Poletti
list of publications in PubMed (updated dec 2020)
"Who and Where" personal data in UNIMI
Principal areas of investigation: Dr. Angelo POLETTI is studying the effects of steroid hormones in the central nervous system. The main projects presently running in Dr. Poletti's laboratory are the following:
1) Motoneuronal degeneration in Spinal and Bulbar Muscular Atrophy (SBMA or Kennedy's disease). Determination of the neurotoxic effects induced by the mutation of the androgen receptor (elongation of the polyglutamic tract in the N-terminal transactivation domain of AR) in Kennedy's disease; preparation of cellular models of SBMA using immortalized motoneuronal cells transfected with the cDNAs coding for the mutated androgen receptors (more references)
2) Motoneuronal degeneration in Amyotrophic Lateral Sclerosis (ALS). Using cellular models similar to those described in point 1, but obtained with cDNA coding for the wt and mutated form of the Superoxyde dismutase (SOD1) responsible for a number of familiar ALS.
3) Androgenic and estrogenic control of prostate and breast cancer cell growth. Analysis of the mechanisms of action of the androgen and estrogens receptor in prostate and breast cancer cells.
4) Effects of gonadal steroids on motoneuronal functions. Characterization of androgen and estrogen receptors in cultured motoneuronal cells. Characterization of steroid-inducible genes (androgen or estrogen dependent) in motoneurons.
Research team:
Collaborators (Assistant Professor and Research Associate)
Rita Galbiati
Paola Rusmini
Valeria Crippa
Riccardo Cristofani
Margherita Piccolella
Post Docs & PhD Students
Veronica Ferrari
Barbara Tedesco
Elena Casarotto
Marta Chierichetti
Marta Cozzi
Francesco Mina
Students