PUBLICATIONS

2023

  1. Cryo-EM structure of hnRNPDL-2 fibrils, a functional amyloid associated with limb-girdle muscular dystrophy D3. Garcia-Pardo J, Bartolomé-Nafría A, Chaves-Sanjuan A, Gil-Garcia M, Visentin C, Bolognesi M, Ricagno S, Ventura S. Nat Commun. 2023 Jan 16;14(1):239. doi: 10.1038/s41467-023-35854-0.
  2. AA-amyloidosis in cats (Felis catus) housed in shelters. Ferri F, Ferro S, Porporato F, Callegari C, Guglielmetti C, Mazza M, Ferrero M, Crinò C, Gallo E, Drigo M, Coppola LM, Gerardi G, Schulte TP, Ricagno S, Vogel M, Storni F, Bachmann MF, Vogt AC, Caminito S, Mazzini G, Lavatelli F, Palladini G, Merlini G, Zini E. PLoS One. 2023 Mar 29;18(3):e0281822. doi: 10.1371/journal.pone.0281822.
  3. Autoantibodies neutralizing type I IFNs underlie West Nile virus encephalitis in ∼40% of patients. Gervais A, Rovida F, Avanzini MA, Croce S, Marchal A, Lin SC, Ferrari A, Thorball CW, Constant O, Le Voyer T, Philippot Q, Rosain J, Angelini M, Pérez Lorenzo M, Bizien L, Achille C, Trespidi F, Burdino E, Cassaniti I, Lilleri D, Fornara C, Sammartino JC, Cereda D, Marrocu C, Piralla A, Valsecchi C, Ricagno S, Cogo P, Neth O, Marín-Cruz I, Pacenti M, Sinigaglia A, Trevisan M, Volpe A, Marzollo A, Conti F, Lazzarotto T, Pession A, Viale P, Fellay J, Ghirardello S, Aubart M, Ghisetti V, Aiuti A, Jouanguy E, Bastard P, Percivalle E, Baldanti F, Puel A, MacDonald MR, Rice CM, Rossini G, Murray KO, Simonin Y, Nagy A, Barzon L, Abel L, Diamond MS, Cobat A, Zhang SY, Casanova JL, Borghesi A. J Exp Med. 2023 Sep 4;220(9):e20230661. doi: 10.1084/jem.20230661. 
  4. Nanobodies Counteract the Toxicity of an Amyloidogenic Light Chain by Stabilizing a Partially Open Dimeric Conformation. Broggini L, Barzago MM, Speranzini V, Schulte T, Sonzini F, Giono M, Romeo M, Milani P, Caminito S, Mazzini G, Rognoni P, Merlini G, Pappone C, Anastasia L, Nuvolone M, Palladini G, Diomede L, Ricagno S. J Mol Biol. 2023 Oct 20;435(24):168320. doi: 10.1016/j.jmb.2023.168320. 
  5. Unravelling Novel SCN5A Mutations Linked to Brugada Syndrome: Functional, Structural, and Genetic Insights. Frosio A, Micaglio E, Polsinelli I, Calamaio S, Melgari D, Prevostini R, Ghiroldi A, Binda A, Carrera P, Villa M, Mastrocinque F, Presi S, Salerno R, Boccellino A, Anastasia L, Ciconte G, Ricagno S, Pappone C, Rivolta I. Int J Mol Sci. 2023 Oct 11;24(20):15089. doi: 10.3390/ijms242015089.
  6. Histological evaluation of the distribution of systemic AA-amyloidosis in nine domestic shorthair cats. Moccia V, Vogt AC, Ricagno S, Callegari C, Vogel M, Zini E, Ferro S. PLoS One. 2023 Nov 2;18(11):e0293892. doi: 10.1371/journal.pone.0293892. 
  7. The Cryo-EM Structure of Renal Amyloid Fibril Suggests Structurally Homogeneous Multiorgan Aggregation in AL Amyloidosis. Puri S, Schulte T, Chaves-Sanjuan A, Mazzini G, Caminito S, Pappone C, Anastasia L, Milani P, Merlini G, Bolognesi M, Nuvolone M, Palladini G, Ricagno S. J Mol Biol. 2023 Sep 15;435(18):168215. doi: 10.1016/j.jmb.2023.168215.
  8. Renal amyloid-A amyloidosis in cats: Characterization of proteinuria and biomarker discovery, and associations with kidney histology. Palizzotto C, Ferri F, Callegari C, Rossi F, Manfredi M, Carcangiu L, Gerardi G, Ferro S, Cavicchioli L, Müller E, Weiss M, Vogt AC, Lavatelli F, Ricagno S, Hurley K, Zini E. J Vet Intern Med. 2023 Nov 22. doi: 10.1111/jvim.16920. 

2022


  1. Cu(II) Binding Increases the Soluble Toxicity of Amyloidogenic Light Chains. Russo R, Romeo M, Schulte T, Maritan M, Oberti L, Barzago MM, Barbiroli A, Pappone C, Anastasia L, Palladini G, Diomede L, Ricagno S. Int J Mol Sci. 2022 Jan 16;23(2):950. doi: 10.3390/ijms23020950
  2. L- to D-Amino Acid Substitution in the Immunodominant LCMV-Derived Epitope gp33 Highlights the Sensitivity of the TCR Recognition Mechanism for the MHC/Peptide Structure and Dynamics. F. Ballabio, L. Broggini, C. Paissoni, X. Han, K. Peqini, B.M. Sala, R. Sun, T. Sandalova, A. Barbiroli, S. Pellegrino, S. Ricagno, C. Camilloni. ACS Omega. 2022, 7, 11, 9622–9635. doi: 10.1021/acsomega.1c06964
  3. Apis mellifera RidA, a novel member of the canonical YigF/YER057c/UK114 imine deiminase superfamily of enzymes pre-empting metabolic damage. Visentin C, Rizzi G, Degani G, Digiovanni S, Robecchi G, Barbiroli A, Popolo L, Vanoni MA, Ricagno S. Biochem Biophys Res Commun. 2022 May 24;616:70-75. doi: 10.1016/j.bbrc.2022.05.062.
  4. An N-glycosylation hotspot in immunoglobulin κ light chains is associated with AL amyloidosis. Nevone A, Girelli M, Mangiacavalli S, Paiva B, Milani P, Cascino P, Piscitelli M, Speranzini V, Cartia CS, Benvenuti P, Goicoechea I, Fazio F, Basset M, Foli A, Nanci M, Mazzini G, Caminito S, Sesta MA, Casarini S, Rognoni P, Lavatelli F, Petrucci MT, Olimpieri PP, Ricagno S, Arcaini L, Merlini G, Palladini G, Nuvolone M. Leukemia. 2022 May 24. doi: 10.1038/s41375-022-01599-w.
  5. Cryo-EM structure of ex vivo fibrils associated with extreme AA amyloidosis prevalence in a cat shelter. Schulte T, Chaves-Sanjuan A, Mazzini G, Speranzini V, Lavatelli F, Ferri F, Palizzotto C, Mazza M, Milani P, Nuvolone M, Vogt AC, Palladini G, Merlini G, Bolognesi M, Ferro S, Zini E, Ricagno S. bioRxiv 2022.05.09.491126; doi: https://doi.org/10.1101/2022.05.09.491126
  6. AA-amyloidosis in cats (Felis catus) housed in shelters. Filippo Ferri, Silvia Ferro, Federico Porporato, Carolina Callegari, Chiara Guglielmetti, Maria Mazza, Marta Ferrero, Chiara Crinò, Enrico Gallo, Michele Drigo, Luigi M. Coppola, Gabriele Gerardi, Tim Paul Schulte, Stefano Ricagno, Monique Vogel, Federico Storni, Martin F. Bachmann, Anne-Cathrine Vogt, Serena Caminito, Giulia Mazzini, Francesca Lavatelli, Giovanni Palladini, Giampaolo Merlini, Eric Zini. bioRxiv 2022.05.04.490646; doi: https://doi.org/10.1101/2022.05.04.490646
  7. Multi-eGO: An in silico lens to look into protein aggregation kinetics at atomic resolution. Scalone E, Broggini L, Visentin C, Erba D, Bačić Toplek F, Peqini K, Pellegrino S, Ricagno S, Paissoni C, Camilloni C. Proc Natl Acad Sci U S A. 2022 Jun 28;119(26):e2203181119. doi: 10.1073/pnas.2203181119.
  8. Single-molecule real-time sequencing of the M protein: Toward personalized medicine in monoclonal gammopathies. Cascino P, Nevone A, Piscitelli M, Scopelliti C, Girelli M, Mazzini G, Caminito S, Russo G, Milani P, Basset M, Foli A, Fazio F, Casarini S, Massa M, Bozzola M, Ripepi J, Sesta MA, Acquafredda G, De Cicco M, Moretta A, Rognoni P, Milan E, Ricagno S, Lavatelli F, Petrucci MT, Miho E, Klersy C, Merlini G, Palladini G, Nuvolone M. Am J Hematol. 2022 Aug 9. doi: 10.1002/ajh.26684. 
  9.  Fragment-based computational design of antibodies targeting structured epitopes. Aguilar Rangel M, Bedwell A, Costanzi E, Taylor RJ, Russo R, Bernardes GJL, Ricagno S, Frydman J, Vendruscolo M, Sormanni P. Sci Adv. 2022 Nov 11;8(45):eabp9540. doi: 10.1126/sciadv.abp9540.
  10. Cryo-EM structure of ex vivo fibrils associated with extreme AA amyloidosis prevalence in a cat shelter. Schulte T, Chaves-Sanjuan A, Mazzini G, Speranzini V, Lavatelli F, Ferri F, Palizzotto C, Mazza M, Milani P, Nuvolone M, Vogt AC, Vogel M, Palladini G, Merlini G, Bolognesi M, Ferro S, Zini E, Ricagno S. Nat Commun. 2022 Nov 17;13(1):7041. doi: 10.1038/s41467-022-34743-2.

2021

  1. Fragment-based computational design of antibodies targeting structured epitopes. Aguilar Rangel M, Bedwell A, Costanzi E, Ricagno S, Frydman J, Vendruscolo M, Sormanni P. bioRxiv doi: https://doi.org/10.1101/2021.03.02.433360
  2. B2-microglobulin triggers NLRP3 inflammasome activation in tumor-associated macrophages to promote multiple myeloma progression. Hofbauer D, Mougiakakos D, Broggini L, Zaiss M, Buttner-Herold M, Bach C, Spriewald B, Neumann F, Bisht S, Nolting J, Zeiser R, Hamarsheh S, Eberhardt M, Vera J, Visentin C, De Luca CMG, Moda F, Haskamp S, Flamann C, Böttcher M, Bitterer K, Völkl S, Mackensen A, Ricagno S, Bruns H. Immunity. 2021 Jul 13:S1074-7613(21)00264-8. doi: 10.1016/j.immuni.2021.07.002.
  3. Protease-sensitive regions in amyloid light chains: what a common pattern of fragmentation across organs suggests about aggregation. Mazzini G, Ricagno S, Caminito S, Rognoni P, Milani P, Nuvolone M, Basset M, Foli A, Russo R, Merlini G, Palladini G, Lavatelli F. FEBS J. 2021 Sep 5. doi: 10.1111/febs.16182.
  4. Neuroserpin: structure, function, physiology and pathology. D'Acunto E, Fra A, Visentin C, Manno M, Ricagno S, Galliciotti G, Miranda E. Cell Mol Life Sci. 2021 Aug 17. doi: 10.1007/s00018-021-03907-6. Review.

2020

  1. Glycosylation Tunes Neuroserpin Physiological and Pathological Properties. Visentin C, Broggini L, Sala BM, Russo R, Barbiroli A, Santambrogio C, Nonnis S, Dubnovitsky A, Bolognesi M, Miranda E, Achour A, Ricagno S. Int J Mol Sci. 2020 May 3;21(9). doi: 10.3390/ijms21093235.
  2. Functionally Divergent Splicing Variants of the Rice AGAMOUS Ortholog OsMADS3 Are Evolutionary Conserved in Grasses. Dreni L, Ravasio A, Gonzalez-Schain N, Jacchia S, da Silva2 GJ, Ricagno S, Russo R, Caselli F, Gregis V, Kater M. Front. Plant Sci., 25 May 2020 | https://doi.org/10.3389/fpls.2020.00637.
  3. Two novel fish paralogs provide insights into the Rid family of imine deaminases active in pre-empting enamine/imine metabolic damage. Digiovanni S, Visentin C, Degani G, Barbiroli A, Chiara M, Regazzoni L, Di Pisa F, Borchert AJ, Downs DM, Ricagno S, Vanoni MA, Popolo L. Sci Rep. 2020 Jun 10:10135 doi: 10.1038/s41598-020-66663-w
  4. Embelin as Lead Compound for New Neuroserpin Polymerization Inhibitors. Visentin C, Musso L, Broggini L, Bonato F, Russo R, Moriconi C, Bolognesi M, Miranda E, Dallavalle S, Passarella D, Ricagno S. Life (Basel). 2020 Jul 11;10(7):E111. doi: 10.3390/life10070111.
  5. Conformational Stability and Dynamics in Crystals Recapitulate Protein Behavior in Solution. Sala BM, Le Marchand T, Pintacuda G, Camilloni C, Natalello A, Ricagno S. Biophys J. 2020 Jul 24:S0006-3495(20)30565-8. doi: 10.1016/j.bpj.2020.07.015.
  6. Mass spectrometry characterization of light chain fragmentation sites in cardiac AL amyloidosis:insights into the timing of proteolysis. Lavatelli F, Mazzini G, Ricagno S, Iavarone F, Rognoni P, Milani P, Nuvolone M, Swuec P, Caminito S, Tasaki M, Chaves-Sanjuan A, Urbani A, Merlini G, Palladini G. J Biol Chem. 2020 Sep 20:jbc.RA120.013461. doi: 10.1074/jbc.RA120.013461.

2019

  1. Investigating the Molecular Basis of the Aggregation Propensity of the Pathological D76N Mutant of Beta-2 Microglobulin: Role of the Denatured State. Visconti L, Malagrinò F, Broggini L, De Luca CMG, Moda F, Gianni S, Ricagno S, Toto A. Int J Mol Sci. 2019 Jan 18;20(2). doi: 10.3390/ijms20020396.
  2. Cryo-EM structure of cardiac amyloid fibrils from an immunoglobulin light chain AL amyloidosis patient. Swuec P, Lavatelli F, Tasaki M, Paissoni C, Rognoni P, Maritan M, Brambilla F, Milani P, Mauri P, Camilloni C, Palladini G, Merlini G, Ricagno S, Bolognesi M. Nat Commun. 2019 Mar 20;10(1):1269. doi: 10.1038/s41467-019-09133-w.
  3. Modulating the cardiotoxic behaviour of immunoglobulin light chain dimers through point mutations. Maritan M, Ambrosetti A, Oberti L, Barbiroli A, Diomede L, Romeo M, Lavatelli F, Sormanni P, Palladini G, Bolognesi M, Merlini G, Ricagno S. Amyloid. 2019;26(sup1):105-106. doi: 10.1080/13506129.2019.1583185.
  4. The concurrency of several biophysical traits links immunoglobulin light chains with toxicity in AL amyloidosis. Oberti L, Maritan M, Rognoni P, Barbiroli A, Lavatelli F, Russo R, Palladini G, Bolognesi M, Merlini G, Ricagno S. Amyloid. 2019;26(sup1):107-108. doi: 10.1080/13506129.2019.1583187.
  5. Biochemical and biophysical comparison of human and mouse beta-2 microglobulin reveals the molecular determinants of low amyloid propensity. Achour A, Broggini L, Han X, Sun R, Santambrogio C, Buratto J, Visentin C, Barbiroli A, De Luca CMG, Sormanni P, Moda F, De Simone A, Sandalova T, Grandori R, Camilloni C, Ricagno S. FEBS J. 2019 Aug 17. doi: 10.1111/febs.15046.
  6. Inherent Biophysical Properties Modulate the Toxicity of Soluble Amyloidogenic Light Chains. Maritan M, Romeo M, Oberti L, Sormanni P, Tasaki M, Russo R, Ambrosetti A, Motta P, Rognoni P, Mazzini G, Barbiroli A, Palladini G, Vendruscolo M, Diomede L, Bolognesi M, Merlini G, Lavatelli F, Ricagno S. J Mol Biol. 2019 Dec 24. pii: S0022-2836(19)30715-6. doi: 10.1016/j.jmb.2019.12.015.

2018

  1. Fragment-based computational design of antibodies targeting structured epitopes. Aguilar Rangel M, Bedwell A, Costanzi E, Ricagno S, Frydman J, Vendruscolo M, Sormanni P. bioRxiv doi: https://doi.org/10.1101/2021.03.02.433360
  2. B2-microglobulin triggers NLRP3 inflammasome activation in tumor-associated macrophages to promote multiple myeloma progression. Hofbauer D, Mougiakakos D, Broggini L, Zaiss M, Buttner-Herold M, Bach C, Spriewald B, Neumann F, Bisht S, Nolting J, Zeiser R, Hamarsheh S, Eberhardt M, Vera J, Visentin C, De Luca CMG, Moda F, Haskamp S, Flamann C, Böttcher M, Bitterer K, Völkl S, Mackensen A, Ricagno S, Bruns H. Immunity. 2021 Jul 13:S1074-7613(21)00264-8. doi: 10.1016/j.immuni.2021.07.002.
  3. Protease-sensitive regions in amyloid light chains: what a common pattern of fragmentation across organs suggests about aggregation. Mazzini G, Ricagno S, Caminito S, Rognoni P, Milani P, Nuvolone M, Basset M, Foli A, Russo R, Merlini G, Palladini G, Lavatelli F. FEBS J. 2021 Sep 5. doi: 10.1111/febs.16182.
  4. Neuroserpin: structure, function, physiology and pathology. D'Acunto E, Fra A, Visentin C, Manno M, Ricagno S, Galliciotti G, Miranda E. Cell Mol Life Sci. 2021 Aug 17. doi: 10.1007/s00018-021-03907-6. Review.

2017


  1. Concurrent structural and biophysical traits link with immunoglobulin light chains amyloid propensity. Oberti L, Rognoni P, Barbiroli A, Lavatelli F, Russo R, Maritan M, Palladini G, Bolognesi M, Merlini G, Ricagno S. Sci Rep. 2017 Dec 1;7(1):16809. doi: 10.1038/s41598-017-16953-7.
  2. FRET studies of various conformational states adopted by transthyretin. Ghadami SA, Bemporad F, Sala BM, Tiana G, Ricagno S., Chiti F. Cell Mol Life Sci. 2017 May 6. doi: 10.1007/s00018-017-2533-x.
  3. An Asp to Asn mutation is a toxic trigger in beta-2 microglobulin: structure and biophysics. de Rosa M, Halabelian L, Barbiroli A, Bolognesi M, Bellotti V, Ricagno S. Amyloid. 2017 Mar;24(sup1):15-16. doi: 10.1080/13506129.2016.1272450.
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