________________________________________________________

IV Meeting on the

MOLECULAR MECHANISMS OF NEURODEGENERATION

Aula Magna, Universita' degli Studi di Milano

Via Festa del Perdono 7 - 20122 Milano (Italy)

May 8-10, 2009

 

 

FINAL PROGRAM

 

 

Friday, May 08, 2009 (Morning)

                           

09:30          Registration

 

10:00                   Satellite symposium on:

                        Molecular Mechanisms on Neurodevelopment

                        Axonal development and targeting

                  (no registration required for this symposium)

                  Chairpersons: Roberto Maggi (Italy), Ivan De Curtis (Italy)

 

Plenary Lecture

10:15-11:00 Patricia Salinas (UK)

                  "Wnt signaling in the regulation of synapse formation and maintenance"

Session

11:00-11:30 Ivan De Curtis (Italy)

                  "Essential role of Rac GTPases in neuronal development"

11:30-12:00 Flavia Valtorta (Italy)

                  "Membrane trafficking in axonal growth cones"

12:00-12:30 Giorgio Merlo (Italy)

                  "Transcription factor regulations of axon targeting: the olfactory system"

 

                  Closing remarks

 

 

Friday, May 08, 2009 (Afternoon)

 

Opening Session

14:00                   Introduction by the organizers

                  Angelo Poletti, Elena Cattaneo, Franco Taroni (Italy)

 

14:10-14:30 Gianpiero Sironi (Prorettore alla ricerca, Universita' di Milano)

                  Stefano Di Donato (Direttore Scientifico Emerito,

                                           Fondazione Istituto Neurologico "Carlo Besta" Milano)

 

Opening lecture

14:30-15:30 Aaron Ciechanover (Israel)

                  The Nobel Prize in Chemistry 2004

                  "The Ubiquitin Proteolytic System:  From Basic Mechanisms via Human Diseases and onto Drug Targeting"

                  Introduced by Ron R. Kopito (USA)

 

Session I: Cellular handling of aberrant neurotoxic proteins I

                  Chairpersons: Marcy McDonald (USA), Caterina Bendotti (Italy)

 

15:30-16:00 Ron Kopito (USA)

                  "Membrane penetration and prion-like propagation of amyloids"

16:00-16:30 Ana Maria Cuervo (USA)

                  "Degradation of misfolded proteins through the autophagic system in the central nervous system"

16:30-17:00 Francesco Fornai (Italy)

                  "The role of autophagy in selective neuronal degeneration: basic evidence and pharmacological manipulation"

 

17:00-17:30 Coffee break

 

Session II: Cellular handling of aberrant neurotoxic proteins II

                  Chairpersons: Piera Pasinelli, (USA), Mario Salmona (Italy)

 

17:30-18:00  Christopher E. Shaw (UK)

                  "TDP-43 mutations in familial and Sporadic Amyotrophic Lateral Sclerosis "

18:00-18. 30 J. Paul Taylor (USA)

                  "Insights into the pathogenesis of TDP-43-related disease from Drosophila models"

18:30-19:00 Erich E. Wanker (Germany)

                  "Modulation of amyloid formation pathways with chemical chaperones"

19:00-19:30 Gianluigi Forloni (Italy)

                  "Protein toxicity in AD and PD "

 

19:30           Welcome Party

 

 

Saturday, May 9, 2009 (Morning)

 

Session III: Mitochondria, oxidative stress, and genotoxicity I

                  Chairpersons: Silvia De Biasi (Italy), Massimo Stefani (Italy)

 

09:00-09:30 Eva-Maria Mandelkow (Germany)

                  "Modes of TAU toxicity and neuronal degeneration"

09:30-10:00 Paolo Bernardi (Italy)

                  "Toward a Mitochondrial Therapy of Collagen VI Muscular Dystrophies.""

10:00-10:30 Franco Taroni (Italy)

                  "Mitochondrial maintenance and spinocerebellar degeneration"

 

10:30-11:00 coffee break

 

Session IV: Mitochondria, oxidative stress, and genotoxicity II

                  Chairpersons: Armando Gennazzani (Italy), Davide Trotti (USA)

 

11:00-11:30  Robert H. Brown (USA)

                  "Genetic determinants of Amyotrophic Lateral Sclerosis"

11:30-12:00 Vittorio Calabrese (Italy)

                  "Nitric Oxide in the brain: neuroprotection versus neurotoxicity"

12:00-12:30 Keith W. Caldecott (UK)

                  "Chromosomal Single-strand break repair and neurological disease"

 

12:30-13:30 Lunch

 

Saturday, May 9, 2009 (Afternoon)

                    

13:30-15:00 Poster Session I (P01-P66)

 

Session V: Role of microRNAs in the neuronal functions and dysfunctions

                  Chairpersons: Robert M. Friedlander (USA), Robert G. Korneluk (Canada)

 

15:00-15:30 Asa Abeliovich (USA)

                  "A MicroRNA feedback circuit in midbrain dopamine neurons"

15:30-16:00 Carlo Cogoni (Italy)

                  "MicroRNA in the brain"

 

16:00-17:00  Selected Free Communication

                  Chairpersons: Franco Taroni (Italy), Giorgio Casari (Italy)

 

OC1 - Role of miRNAs regulation on CDK5R1 expression in Alzheimer's disease

         Moncini S, Zuccotti P, Venturin M, Salvi A, Sabelli C, De Petro G, Barlati S, Riva P. (Italy)

OC2 - Identifying genes that modify Huntington's disease in the N171-82Q mouse model.

         Corrochano-Sanchez S, Acevedo-Arozena A, Rubinsztein DC, Brown SDM (UK)

OC3 - Modifiers of aggregation in neurodegenerative diseases

         Holmberg M, van Ham TJ, Thijssen KL, van Rheenen J, van Veluw J, Hofstra RMW, Nollen EAA (The Netherland)

OC4 - Analysis of inducible mouse model of Huntington disease combined with ubiquitin-proteasome system reporter mice.

         Ortega Z, Maynard CJ,  Diaz-Hernandez M, Dantuma NP, Lucas JJ (Spain)

 

17:00-17:30 Coffee break

 

17:30-19:30  Selected Free Communication

                  Chairpersons: Franco Taroni (Italy), Giorgio Casari (Italy)

 

OC5 - Polyglutamine toxicity induces multiple photoreceptor degeneration pathways and complex retinal remodelling in a SCA7 mouse model

         Trottier Y, Messaddeq N, Jacquard C, Weber C, Karem A, Wolfrum U, Jonet L, Jeanny JC, Yefimova MG (France)

OC6 - AGLF2 mutations cause autosomal dominant ataxia and

         DiBella D, Lazzaro F, Brusco A, Battaglia G, Pastore A, Finardi A, Fracasso V, Magri S, Plumari M, Cagnoli C, Tempia F, Brussino A, Gellera C, Mariotti C, Plevani P, DiDonato S, Langer T, Muzi-Falconi M, Taroni F (Italy)

OC7 - Heat shock response and misfolded protein elimination associated with PHOX2B polyalanine expansion and GFAP mutations in congenital central hypoventilation syndrome and Alexander disease

         Bachetti T, Di Zanni E, Bocca P, Borghini S, Prigione I, Caroli F, Filocamo M, Balbi P, Biancheri R, Ravazzolo R, Ceccherini I (Italy)

OC8 - Molecular mechanism of the regulation of two ER stress-mediated degradation system, UPS and autophagy/lysosome, of the misfolded protein.

         Kouroku Y, Fujita E, Momo YM, Momoi T (Japan)

OC9 - Polyglutamine atrophin provokes autophagic neurodegeneration by repressing the tumour suppressor FAT

         Charroux B, Occhi S, Nisoli I, Napoletano F, Chauvin JP, Calamita P, Volpi VG, Zanin V, Fanto M (Italy)

OC10 - The nucleolus as source of oxidative damage and neurodegeneration.

         Parlato R, Rieker C, Kreiner, Engblom D, Bierhoff H, Grummt I, Schutz G (Germany)

OC11 - Aggresome-forming TTRAP mediates pro-apoptotic properties of ParkinsonŐs disease-associated DJ-1 missense mutations

         Zucchelli S, Vilotti S, Calligaris R, Lavina ZS, Biagioli M, Foti R, De Maso L, Pinto M, Gorza M, Speretta E, Casseler C, Tell G, Del Sal G, Gustincich S (Italy)

OC12 - Role of dopamine-induced calcium signalling in neurodegeneration of control and PINK1 knockout neurons and astrocytes.

         Vaarmann A, Abramov AY (UK)

 

20:30           Social Dinner

 

 

Sunday, May 10, 2009 (morning)

 

08:30-10.00 Selected Free Communications

                  Chairpersons: Angelo Poletti (Italy), Giorgio Battaglia (Italy)

 

OC13 - Role of PPP4R2 in apoptosis and neuritogenesis

         Bosio Y, Camera P, Berto G, Ambrogio C, Silengo L, Di Cunto F (Italy)

OC14 - The Zing Finger protein ZPR1 deficiency causes activation of the JNK signaling cascade and neuron degeneration

         Ahmad S, Gangwani L (USA)

OC15 - Influence of post-translational modifications on the androgen receptor in SBMA

         Jochum T, Ritz ME, Moss D, Cato ACB (Germany)

OC16 - Effect of selective androgen receptor modulators in SBMA experimental models.

         Bolzoni E, Orr CR, Liu Y, McDonnell D, Wilson E, Merry DE (USA).

OC17 - Disruption of dynein/dynactin function in neurons in vivo does not lead to motor abnormalities in transgenic mice and improves lifespan in the SOD1-ALS mouse model

         Teuling E, van Dis V, Wulf PS, Haasdijk ED, Akhmanova A, Hoogenraad CC, Jaarsma D (USA)

OC18 - Spinal cord from an animal model of ALS: a potential source of adult neural stem cells in response to neurodegeneration.

         Marcuzzo S, Preite L, Cappelletti C, Zingale A, Terragni B, Mantegazza M,  Bernasconi P, Mantegazza R (Italy)

 

10:00-10:30 coffee break

 

Session VI: Altered protein functions in neurodegenerative diseases  
Chairpersons: Marian Di Figlia (USA), Neil Aronin (USA)

 

10:30-11:00 Angelo Poletti (Italy)

                  "Clearance of misfolded proteins in SBMA and ALS"

11:00-11:30 Daniela Rossi (Italy)

                  "Role of astroglia on motor neuron cell survival and death in ALS"

11:30-12:00 Elena Cattaneo (Italy)

                  "BDNF, Huntingtin and neuronal cell death"

12:00­-12:30 Patrik Brundin (Sweden)

                  "Can Parkinson's Disease pathology be propagated from one neuron to another?"

 

12:30-13:30 Lunch

 

 

Sunday, May 10, 2009 (afternoon)

 

13:30-15:00 Poster Session II (67-133)

 

Session VI: Genetic determinants of Neurodegenerative diseases

                  Chairpersons: Elena Cattaneo (Italy), Stefano DiDonato (Italy)

 

15:00-15:30  Fabrizio Tagliavini (Italy)

                  "Good Gene, Bad Gene: New APP Variant May Be Both"

15:30-16:00 Piera Pasinelli (USA)

                  "Alteration of mitochondrial functions in amyotrophic lateral sclerosis"

16:00-16:30 James F. Gusella (USA)

                  "Modifier genes in Huntington's disease"

16:30-17:00 Michael R. Hayden (Canada)

                  "Bad Boys and the Pathogenesis of HD"

 

17:00           Closing Remarks

 

 

 

POSTERS

 

Poster Session I (P01-P66)

 

Saturday, May 9, 2009

from 13:30 to 15:00

 

________________________________________________________________________

 

P01 - ALS GENES: MUTATIONAL ANALYSIS IN A LARGE COHORT OF ITALIAN PATIENTS

            Gellera C*, Ticozzi N, Ratti A, Corrado L, Castellotti B, Colombrita C, Plumari M, Carlomagno Y, Bragato C, Mazzini L, Taroni F, Silani V

 

P02 - DOWN CRITICAL REGION-ENCODED PROTEIN TTC3 INHIBITS NEURONAL DIFFERENTIATION IN HIPPOCAMPAL NEURONS

            Berto G*, Camera P, Dotti CS, Di Cunto F

 

P03 - AN OLD PROTEIN IN UNEXPECTED PLACES: ALPHA- AND BETA- GLOBIN EXPRESSION IN MESENCEPHALIC DOPAMINERGIC NEURONS AND GLIAL CELLS

            Biagioli M*, Pinto M*, Cesselli D, Zaninello M, Lazarevic D, Simone R, Vlachouli C, Plessy C, Bertin N, Beltrami A, Kobayashi K, Gallo V, Santoro C, Ferrer I, Rivella S, Beltrami CA, Carninci P, Raviola E, Gustincich S

 

P04 - MUTATIONAL SCREENING AND FUNCTIONAL ANALYSES IN THE ZEBRAFISH MODEL OF GIGYF2 AS A CANDIDATE GENE FOR PARKINSON DISEASE

            Guella I*, Del Giacco L, Asselta R, Pistocchi A, Rimoldi V, Sironi F, Primignani P, Zini M, Pezzoli G, Duga S, Goldwurm S

 

P05 - FMR1 GENE TESTING IN THE FAMILY WITH ATAXIA AND TREMOR

            Rajkiewicz M, Kaca-Orynska M, Sulek-Piatkowska A, Krysa W, Koziorowski D, Friedman A

 

P06 - MODELING THE NEUROLOGICAL FEATURES OF TUBEROUS SCLEROSIS COMPLEX BY SELECTIVE TARGETING OF EMBRYONIC AND ADULT NEURAL STEM CELLS IN MICE

            Magri L, Galli R

 

P07 - RELATIONSHIP BETWEEN AF4 EXPRESSION LEVELS AND THE TIME FRAME/ONSET OF NEURODEGENERATION IN THE ROBOTIC MOUSE

            Mattia J Finelli*, Emmanuelle Bitoun, Sheena Lee, Peter L Oliver, Kay E Davies

 

P08 - A MODEL OF SPINOCEREBELLAR ATAXIA TYPE 2 (SCA2): THE (CAG)102-SCA2 KNOCK-IN MOUSE

            Damrath E*, Gispert S, Nonis FD, Lastres-Becker I, Nowock J, Auburger G

 

P09 - MUTATION ANALYSIS OF THE SPG11 AND SPG15 GENE IN ITALIAN PATIENTS WITH SPASTIC PARAPLEGIA AND THIN CORPUS CALLOSUM

            Castellotti B*, Mariotti C, Pensato V, Fancellu R, Salsano E, Gellera C, Pareyson D, Taroni F

 

P10 - ALPHA-SYNUCLEIN POINT MUTATION ANALYSIS IN ITALIAN PATIENTS WITH AUTOSOMAL DOMINANT PARKINSON DISEASE

            Francesca Sironi, Luca Trotta, Michela Zini, Silvana Tesei, Paola Primignani, Tiziana Brambilla, Domenico A Coviello, MD, Gianni Pezzoli, MD, Stefano Goldwurm

 

P11 - ALTERNATIVE SPLICING ENHANCES LYSINE SPECIFIC DEMETHYLASE 1 (LSD1) EPIGENETIC TUNEABILITY IN THE MAMMALIAN NERVOUS SYSTEM.

            Zibetti C*, Mattevi A, Sala C, Battaglioli E


P12 - INCREASED SUSCEPTIBILITY OF CORTICAL SPREADING DEPRESSION IN ATP1A2 KNOCK-IN MOUSE MODEL OF FAMILIAL HEMIPLEGIC MIGRAINE TYPE2

            Loredana Leo, Lisa Gherardini, Virginia Barone, Tommaso Pizzorusso, Giorgio Casari

 

P13 - HAPLOINSUFFICIENCY OF AFG3L2, THE GENE RESPONSIBLE FOR SPINOCEREBELLAR ATAXIA TYPE 28 (SCA28), CAUSES MITOCHONDRIAL-MEDIATED PURKINJE CELL DEGENERATION

            Maltecca F*, Magnoni R, Cox G, Quattrini A, Casari G

 

P14 - ROLES OF ERYTHROPOIETIN AND SONIC HEDGEHOG IN NEUROPROTECTIVE EFFECTS OF BRAIN-DERIVED NEUROTROPHIC FACTOR AGAINST MITOCHONDRIAL DYSFUNCTION

            Ding-I Yang*, Chia-Lin Wu

 

P15 - INTERPLAY BETWEEN GLUTAMINE AVAILABILITY, GLUTAMATE AND GLUTATHIONE IN A CELL MODEL FOR FAMILIAL FORMS OF AMYOTROPHIC LATERAL SCLEROSIS

            DŐAlessandro G*, Calcagno E, Tartari S, Rizzardini M, Invernizzi RW, Cantoni L

 

P16 - NEURAL TUBE DEFECTS

            Angeles Cavero

 

P17 - NITROPROTEOMICS OF PERIPHERAL BLOOD MONONUCLEAR CELLS FROM PATIENTS AND RAT MODEL OF ALS

            Pozzi S*, Nardo G, Lauranzano E, Mantovani S, Garbelli S, Marinou K, Basso M, Mora G, Bendotti C, Bonetto V

 

P18 - TOWARDS THE BIOCHEMICAL CHARACTERIZATION OF SELADIN-1/DHCR24: HETEROLOGOUS PRODUCTION OF THE HUMAN PROTEIN

            Zucchini D, Caprini G, Criaco L, Vanoni MA

 

P19 - MORPHOLOGICAL CHANGES IN HUNTINGTON'S DISEASE MITOCHONDRIA SUSTAIN THEIR INCREASED SUSCEPTIBILITY TO APOPTOTIC STIMULI

            Veronica Costa*, Dmitry Lim, Ernesto Carafoli, Mauro Piacentini, Walter Malorni, Luca Scorrano

 

P20 - STUDIES ON CONE CELL DEATH MECHANISMS IN THE CPFL1 MOUSE MODEL

            Trifunovic D*, Dengler K, Michalakis S, Biel M, Paquet-Durand F

 

P21 - APOPTOSIS INDUCED BY PLATINUM COMPOUNDS IN B50 CELLS

            Santin G*, Bottone MG, Piccolini VM, Veneroni P, De Pascali SA, Migoni D, Marsigliante S, Fanizzi FP, Bernocchi G

 

P22 - CISPLATIN ANALOGUES WITH NEW SUBCELLULAR TARGETS: A STRATEGY TO PREVENT NEUROTOXICITY INDUCED BY PLATINUM COMPOUNDS?

            Cerri S*, De Pascali SA, Migoni D, Marsigliante S, Fanizzi FP, Bernocchi G

 

P23 - IN VIVO CHARACTERIZATION OF HUMAN NEURAL STEM ECLLS IMMORTALIZED WITH v-MYC (IhNSC) BY TRANSPLANTATION INTO ISCHEMIC RAT BRAIN

            Lidia De Filippis, Laura Rota Nodari, Daniela Ferrari, Fabrizio Giani, Cristina Zalfa, Guido Santilli, Angelo Luigi Vescovi

 

P24 - ABETA AGGREGATE TOXICITY DEPENDS ON MEMBRANE CHOLESTEROL CONTENT IN FAMILIAL ALZHEIMER'S FIBROBLASTS

            Evangelisti E*, Zampagni M, Wright D, Liguri G, Puccetti B, Bagnoli S, Nacmias B, Sorbi S, Cecchi C

 

P25 - INVOLVMENT OF D-SERINE RACEMASE DURING NEURONAL CELL DEATH

            Nadia Canu, Fulvio Florenzano, Anna di Luzio, Tiziana Borsello, Maria Teresa Ciotti

 

P26 - MITOCHONDRIAL INVOLVEMENT IN CLN1 FIBROBLASTS

            Pezzini F*, Sembenini D, Vattemi G, Tonin P, Gismondi F, Marconi MG Carrozzo R, Santorelli FM, Simonati A

 

P27 - PINK1 AND MITOCHONDRIAL DYSFUNCTION IN NEURONS AND SKELETAL MUSCLE CELLS

            Zhi Yao, Sonia Gandhi, Iain Hargreaves, Helene Plun-Favreau, Andrey Y Abramov, Nicholas W Wood

 

P28 - CERULOPLASMIN DIFFERENTIAL EXPRESSION IN THE CEREBROSPINAL FLUID OF PARKINSON'S DISEASE REFLECTS OXIDATION AND FUNCTIONAL IMPAIRMENT FAVOURING INTRACELLULAR IRON OVERLOAD

            Olivieri S, Iannaccone S, Conti A, Cannistraci CV, Piccio L, Franciotta D, Cappa S, Alessio M

 

P29 - ANALYSIS OF IRON HOMEOSTASIS IN SKIN FIBROBLASTS FROM PANTOTHENATE KINASE ASSOCIATED NEURODEGENERATION PATIENTS

            Campanella A, Rovelli E, Garavaglia B, Levi S

 

P30 - BETA-AMYLOID ACTIVATES PARP THROUGH FREE RADICAL GENERATION BY THE NADPH OXIDASE

            Abeti R*, Abramov AY, Duchen MR

 

P31 - GENOPOLIS CONSORTIUM FOR FUNCTIONAL GENOMICS- THE CORE FOR EXPLOITING MICROARRAY THECNOLOGIES

            Biancolini D, Papagna A, Lenzken C, Bonanno D, Barabino SML, Castagnoli-Ricciardi P, Calogero RA, Zolezzi F*

 

P32 - MITOCHONDRIAL DYSFUNCTION IN EXPERIMENTAL CHARCOT-MARIE-TOOTH TYPE 1A (CMT1A) NEUROPATHY

            Lucilla Nobbio*, Fulvia Fiorese Valeria Prada, Silvia Ravera, Mariapaola Nitti, Angelo Schenone

 

P33 - AXONUCLEAR COMMUNICATION SYSTEM IS ALTERED IN MOTOR NEURONS OF RODENT MODELS OF FAMILIAL AMYOTROPHIC LATERAL SCLEROSIS

            Peviani M*, Spano G, Pagani A, Bendotti C

 

P34 - PURKINJE CELL AXONAL INJURY IN THE CEREBELLUM OF Ts65Dn MICE: ROLE OF BETA-AMYLOID OVERLOAD

            Lomoio S*, Necchi D, Scherini E

 

P35 - PENTAPEPTIDES DERIVED FROM A-BETA 1-42 PROTECT NEURONS FROM THE MODULATORY EFFECT OF A-BETA OLIGOMER IN VIVO ELECTROPHYSIOLOGICAL STUDIES

            Chiovini B*, Barkczi B, Juhsz G, FÄl†p L, Penke B, Szegedi V

 

P36 - SYNAPTIC PLASTICITY STUDIES IN APOB-100 TRANSGENIC MICE IN CORRELATE TO ALZHEIMERŐS DISEASE

            Chiovini B*, Barkczi B*, Juhsz G, Bereczki E, Sntha M, Penke B, Szegedi V

 

P37 - MUTANT PRION PROTEIN EXPRESSION IS ASSOCIATED TO AN ALTERATION OF THE RAB GDP DISSOCIATION INHIBITOR ALPHA(GDI)/RAB11 PATHWAY

            Massignan T, Biasini E, Salmona M, Harris DA, Chiesa R, and Bonetto V

 

P38 - CHARACTERIZATION OF DETERGENT-INSOLUBLE PROTEINS IN ALS MODELS AND PATIENTS INDICATES A POSSIBLE CAUSAL LINK BETWEEN NITRATIVE STRESS AND AGGREGATION IN PATHOGENESIS

            Manuela Basso, Giuseppina Samengo, Giovanni Nardo, Tania Massignan, Giuseppina DŐAlessandro, Silvia Tartari, Lavinia Cantoni, Marianna Marino, Cristina Cheroni, Silvia De Biasi, Mario Salmona, Caterina Bendotti, Valentina Bonetto*

 

P39 - THE ACTIVITY OF NMDA RECEPTOR IS ENHANCED BY THE FIBRILLAR A-BETA 1-42 VIA THE INTEGRIN RECEPTOR PATHWAY

            Barkczi B*, Chiovini B, Juhsz G, FÄl†p L, Penke B, Szegedi V

 

P40 - ALPHA-SYNUCLEIN IS AN ACTIN BINDING PROTEIN AND ITS A30P MUTANT AFFECTS THE CYTOSKELETON STRUCTURE AND DYNAMICS

            Bellani S*, Sousa VL, Giannandrea M, Meldolesi J, Valtorta F, Chieregatti E

 

P41 - ACUTE OR CHRONIC CO-TREATMENT WITH 1-METHYL-4-PHENYLPYRIDINIUM (MPP+) AND EPOXOMICIN IN ORGANOTYPIC CULTURES OF MOUSE MESENCEPHALON: SYNERGISTIC TOXICITY OR ALPHA-SYNUCLEIN AGGREGATES?

            Rossen S, Larsen TR, Gramsbergen JB

 

P42 - MIS-SPLICING OF MICROTUBULE-ASSOCIATED TAU IN MYOTONIC DYSTROPHY TYPE: IMPLICATION OF CUGBP1 AND MBNL1

            Dhaenens CM, Tran H, Schraen-Maschke, Sistiaga, A, Goicoechea M, Obriot H, Ghanem D, Van Brussel E, Gavaert MH, Maurage CA, Buae L, Sablonniare B, Lopez de Munain A, Caillet-Boudin ML, Sergeant N

 

P43 - ATAXIN-3 BINDS TUBULIN WITH HIGH AFFINITY

            Mazzucchelli S*, De Palma A, DŐurzo A, Pozzi C, Pastori V, Comelli F, Fusi P, Vanoni M, Tortora P, Mauri PL, Regonesi ME

 

P44 - EXPERIMENTAL MODELS: TOWARD STUDYING MECHANISMS OF NEUROFIBRILLARY DEGENERATION

            Hamdane M*, Desmerciares J, Burnouf S, Bouafia H, Belarbi K, Troquier L, Demeyer D, Grosjean ME, Caillierez R, Barbot B, Brion I, Fernandez Gomez FJ, Humez S, Sergeant N, Blum D, Buae L

 

P45 - INHIBITION OF CALPAINS PREVENTS TRANSLOCATION OF MUTANT ATAXIN-3 TO THE NUCLEUS AND REDUCES NEURODEGENERATION IN A LENTIVIRAL MOUSE MODEL OF MACHADO-JOSEPH DISEASE

            Simoes AT*, Goncalves N, Nbrega C, Deglon N, Bandeira Duarte C, Kugler S, Pereira de Almeida L

 

P46 - ADENOSINE A2A RECEPTORS ANTAGONISM DELAYS NEURODEGENERATION IN A LENTIVIRAL MOUSE MODEL OF MACHADO JOSEPH DISEASE

            Goncalves N*, Simoes AT Cunha R, Pereira de Almeida L

 

P47 - COMPARATIVE ANALYSIS OF STRUCTURAL AND FUNCTIONAL PROPERTIES OF BETA-AMYLOID AGGREGATED SPECIES

            Denise Ferrera*, Claudio Canale, Fabio Benfenati, Laura Gasparini

 

P48 - SIMILAR OLIGOMERS OF HYPF-N SHOW DIFFERENT CYTOTOXIC EFFECTS

            Zampagni M*, Becatti M, Wright D, Campioni S, Mannini B, Cascella R, Chiti F, Stefani M, Cecchi C

 

P49 - CELL DAMAGE INDUCED BY EXPANDED ATAXIN-1 INVOLVES MECHANICAL INSTABILITY OF NUCLEAR MEMBRANE

            Averaimo S, Canale C, Pesci D, Fortunati V, Paulis D, Gliozzi A, Relini A, Mazzanti M, Jodice C*

 

P50 - PORCINE NEURONAL MODELS THAT RECAPITULATE HD PATHOGENESIS IN VITRO

            Hruska-Plochan M*, Vodicka P, Lackova M, Usvald D, Juhas S, Hrdlickova R, Miyanohara A, Marsala M, Motlik J

 

P51 - NEW INSIGHTS INTO THE FIBRILLOGENESIS PROCESS OF ATAXIN-3, A MODEL PROTEIN FOR STUDIES ON POLYQ DISEASES

            Invernizzi G, Frana AM, Aprile FA, Natalello A, Relini A, Doglia SM, Tortora P, Regonesi ME

 

P52 - ATAXIN-3 PROTEIN CONTEXT AND CELL-SPECIFIC FACTORS MODULATE POLYQ-MEDIATED NEURONAL AGGREGATION IN A C ELEGANS MODEL OF MACHADO-JOSEPH DISEASE

            Andreia Teixeira-Castro, Richard Morimoto, Patricia Maciel

 

P53 - EFFECT OF SOD1 EXPRESSION IN A MUSCLE CELL MODEL OF FAMILIAL AMYOTROPHIC LATERAL SCLEROSIS

            Onesto E, Galbiati M, Zito A, Sau D, Crippa V, Poletti A

 

P54 - ROLE OF JNK IN EXCITOTOXIC CELL DEATH FOLLOWING SEIZURE ACTIVITY

            *G Spigolon, C Veronesi, T Herdegen, C Bonny, A F Vercelli

 

P55 - VEGF PROTECTS MOTOR NEURONS AGAINST EXCITOTOXICITY BY UPREGULATION OF GLUR2

            Elke Bogert*, Philip Van Damme, Koen Poesen, Joke Dhondt, Nicole Hersmus, Dora Kiraly, Wendy Scheveneels, Wim Robberecht & Ludo Van Den Bosch

 

P56 - ROLE OF JNK IN EXCITOTOXIC CELL DEATH FOLLOWING SEIZURE ACTIVITY

            *G Spigolon, C Veronesi, T Herdegen, Y Zhao, C Bonny, A E Vercelli

 

P57 - LOSS OF PARKIN PROTEIN CAUSES ABNORMAL INTRACELLULAR CALCIUM LEVELS UPON GLUTAMATERGIC STIMULATION IN NEURONAL CELLS

            Sassone J,Ascardi C,Zippel R,Colciago C, Tiloca C, Silani V, Ciammola A

 

P58 - RETINOIC ACID INHIBITS P38-PHOSPHORYLATION AND PROTECTS AGAINST PREFIBRILLAR BETA-AMYLOID AND GLUTAMATE TOXICITY

            Zoia CP*, Riva C, Proserpio P, Salerno D, Tremolizzo L, Ferrarese C

 

P59 - CEFTRIAXONE TREATMENT IMPROVES PHENOTYPE IN A MURINE MODEL OF SPINAL MUSCULAR ATROPHY

            D Ronchi*, M Nizzardo, M Nardini, S Salani, C Simone, M Falcone, C Donadoni, NBresolin, GP Comi, S Corti,

 

P60 - HIGH AFFINITY GLUTAMATE TRANSPORTERS GLAST AND EAAC1 ARE PRESENT IN SCHWANN CELLS

            Magnaghi V, Di Cairano ES, Ballabio M, Perego C

 

P61 - MUSCLE-RESTRICTED OVEREXPRESSION OF IGF-1 ATTENUATES DISEASE IN A MOUSE MODEL OF SPINAL AND BULBAR MUSCULAR ATROPHY

            Pennuto M, Palazzolo I, Kong L, Sumner C, Hadachi H, Katsuno M, Sobue G, Taylor JP, Fischbeck K

 

P62 - PROTEOMIC PROFILING OF PRP27-30-ENRICHED PREPARATIONS EXTRACTED FROM THE BRAIN OF HAMSTERS WITH EXPERIMENTAL SCRAPIE

            Giorgi A, Di Francesco L, Principe S, Mignogna G, Sennels L, Mancone C, Alonzi T, Sbriccoli M, De Pascalis A, Rappsilber J, Cardone F, Pocchiari M, Maras M, Schinine ME*

 

P63 - CHARACTERIZATION OF THE MOLECULAR DIVERSITY OF PRION PROTEIN AGGREGATES

            E Biasini, L Tapella, R Chiesa

 

P64 - A NEW TRANSGENIC MOUSE MODEL OF INHERITED PRION DISEASE

            Dossena S, Imeri L, Mangieri M, Garofoli A, Ferrari L, Senatore A, Restelli E, Balducci C, Fiordaliso F, Salio M, Bianchi S, Fioriti L, Morbin M, Pincherle A, Marcon G, Villani F, Carli M, Tagliavini F, Forloni G, Chiesa R

 

P65 - RRS1 IS INVOLVED IN ENDOPLASMIC RETICULUM STRESS RESPONSE IN HUNTINGTON'S DISEASE

            Carnemolla A*, Fossale E*, Agostoni E, Michelazzi S, Calligaris R, De Maso L, Del Sal G, MacDonald ME, Persichetti F

 

P66 - MUTANT PRION PROTEIN EXPRESSION CAUSES IMPAIRMENT OF VOLTAGE-GATED CALCIUM CHANNELS IN A TRANSGENIC MOUSE MODEL

            Senatore A, Colleoni S, Verderio C, Restelli E, Mantovani S, Condliffe S, Congi L, Prestori F, Forloni G, DŐAngelo E, Matteoli M, Gobbi M, Chiesa R


 

Poster Session I (P67-P133)

 

Sunday, May 10, 2009

from 13:30 to 15:00

 

________________________________________________________________

 

P67 - MOLECULAR AND FUNCTIONAL ANALYSIS OF PARAPLEGIN GENE (SPG7) MUTATIONS IN PATIENTS WITH FAMILIAL AND SPORADIC SPASTIC PARAPLEGIA

            D DiBella*, M Plumari, S Magri, V Fracasso, F Lazzaro, M Muzi-Falconi, R Fancellu, S DiDonato, D Pareyson, C Gellera, C Mariotti, S Baratta, F Taroni

 

P68 - EXPRESSION MODULATION OF A SMALL HEAT SHOCK PROTEIN INVOLVED IN NEURODEGENERATIVE DISEASES

            Crippa V*, Boncoraglio A, Simonini F, Rusmini P, Poletti A

 

P69 - ROLE OF ALTERED PROTEOLYSIS IN THE DEGENERATION OF MOTOR NEURONS IN IN VIVO MODELS OF FAMILIAL AMYOTROPHIC LATERAL SCLEROSIS INVOLVEMENT OF CONSTITUTIVE AND IMMUNO PROTEASOMES

            Fontana E*, Vitellaro-Zuccarello L, Cheroni C, Marino M, De Biasi S, Bendotti C

 

P70 - TDP-43 REDISTRIBUTION IS AN EARLY EVENT IN SPORADIC AMYOTROPHIC LATERAL SCLEROSIS

            Giordana MT,Piccinini M,Grifoni S*, De Marco G, Vercellino M,Magistrello M, Pellerino A, Buccinn B, Lupino E, Rinaudo MT

 

P71 - AUTOPHAGIC CLEARANCE OF THE PARKINSON'S DISEASE-ASSOCIATED GPR37 RECEPTOR

            Di Pietro C, Marazziti D, Golini E, Mandillo S, Matteoni R, Tocchini-Valentini GP

 

P72 - GEC1 : A NEW AUTOPHAGY EFFECTOR HIGHLY EXPRESSED IN THE SNC

            Chakrama FZ*, Seguin S, Fraichard A, Delage-Mourroux R, Jouvenot M, Boyer-Guittaut M

 

P73 - GREY-LETHAL MOUSE: A MURINE MODEL FOR MALIGNANT OSTEOPETROSIS AND A NEW NEURONAL LYSOSOMAL STORAGE DISEASE

            Frattini A, De Biasi S, Strina D, Vitellaro Zuccarello L, Fontana E, Gioria M, Valnegri P, Sala C, Costantino-Ceccarini E

 

P74 - BRAIN NEURODEGENERATION AND INTERFERON GENE EXPRESSION ANALYSIS IN THE CEREBRO-SPINAL FLUID OF AICARDI-GOUTIRES PATIENTS

            Izzotti A, Cartiglia C, Longobardi M, Pulliero A

 

P75 - TRANSCRIPTIONAL SIGNATURES IN NEURODEGENERATIVE DISEASES

            Daniela Diamanti*, Pollio Giuseppe, Tarditi Alessia, Remelli Rosaria, Caricasole Andrea

 

P76 - THE EXPRESSION OF THE STEROIDOGENIC ACUTE REGULATORY PROTEIN (STAR) IS INCREASED IN THE DEGENERATING TRAIT OF SPINAL CORD OF WOBBLER MICE

            Tartari S*, Bigini P, Orly J, Mennini T, Cantoni L

 

P77 - REST, THE TRANSCRIPTION REPRESSOR THAT GOVERNS NEUROSECRETION EXPRESSION, APPEARS TO HAVE A ROLE ALSO IN THE EXPRESSION OF GLIOSECRETION

            Prada I*, DŐAlessandro R, Stucchi L, Meldolesi J

 

P78 - PARK2 PATIENT FIBROBLASTS TRANSCRIPTOME ANALYSES INDICATE A ROLE OF PARKIN IN ENDOCYTOSIS

            Klinkenberg M*, Gispert S, Morales-Gordo B, Walter M, Auburger G

 

P79 - AMYOTROPHIC LATERAL SCLEROSIS: A HIGH THROUGHPUT ANALYSIS USING PHARMACOLOGICAL AND GENETICALLY MODIFIED CELLULAR MODELS

            Lenzken SC*, Della Beffa C, Bonanno D, Zolezzi F, Vivarelli S, Carri' MT, Calogero R, Barabino SML

 

P80 - TNF-ALPHA mRNA AND PROTEIN EXPRESSION IN SPORADIC ALS PATIENTS

            Guareschi S, Cova E, Baiocchi C, Milani O, Federici Canova D, Cuccia M, Ceroni M, Cereda C*

 

P81 - REGULATION OF MRNA STABILITY BY THE RNA BINDING PROTEIN TNRC4 IN NEURONAL DIFFERENTIATION

            Viero G*, Vessey J, Savino M, DŐApolito M, Grifa A, Macchi P ,Quattrone A

 

P82 - TRANSCRIPTIONAL REGULATION OF GLYCOSPHINGOLIPIDS DEGRADING ENZYMES

            Urbanelli L, Trivelli F, Magini A, Tancini B, Ciccarone V, Polidoro M, Emiliani C*

 

P83 - PATHOGENETIC MECHANISMS IN THE CONGENITAL CENTRAL HYPOVENTILATION SYNDROME (CCHS)

            Benfante R*, Di Lascio S, Bachetti T, Ceccherini I, Fornasari D

 

P84 - TRANSCRIPTIONAL CHANGES IN A CELLULAR MODEL OF HUNTINGTONŐS DISEASE

            Rosenstock TR*, Oliveira CR, Rego AC

 

P85 - MICROARRAY ANALYSIS UNVEILS THE INVOLVEMENT OF ADDITIONAL PATHWAYS IN DJ-1 MEDIATED NEURODEGENERATION

            Foti R, Zucchelli S, Biagioli M, Roncaglia P, Pinto M, Carrieri C, Vilotti S, Krmac H, Calligaris R, Gustincich S

 

P86 - GENE DYSREGULATION IN FRAGILE X-ASSOCIATED TREMOR/ATAXIA SYNDROME

            F Tassone F, Garcia-Arocena D, Iwahashi C, Greco C, Hagerman RJ, PJ Hagerman PJ

 

P87 - STUDIES ON THE PATHOPHYSIOLOGY OF NEUROLOGICAL INVOLVEMENT IN A MUCOPOLYSACCHARIDOSIS TYPE I MOUSE MODEL

            Marika Salvalaio, Rosella Tomanin, Elisa Legnini, Francesca DŐAvanzo, Antonello DŐArrigo, Alberta Leon, Maurizio Scarpa

 

P88 - OXIDATIVE AND ANTIOXIDANT MARKERS IN PATIENTS WITH NEURODEGENERATIVE DISEASES: A PILOT STUDY TO ESTIMATE RISK AND PROTECTIVE FACTORS

            Gironi Russo Bianchi Angelini Martinelli-Boneschi Cursano MarianiBonalumi KulmannCeresa Farina, Alberoni Nemni

 

P89 - EFFECTS OF BEE VENOM ON SYMPTOMATIC AMYOTROPHIC LATERAL SCLEROSIS MODEL

            Eun Jin Yang, Jing Hua Jiang, Hye Suk Hwang, Myeong Soo Lee, Sun Mi Choi

 

P90 - POSTTRAUMATIC GABA(A)-MEDIATED [Ca2+]I INCREASE IS ESSENTIAL FOR THE INDUCTION OF BDNF-DEPENDENT SURVIVAL OF MATURE CENTRAL NEURONS

            Shulga A*, Thomas-Crusells J, Sigl T, Blaesse A, Mestres P, Meyer M, Yan Q, Kaila K, Saarma M, Rivera C, Giehl KM

 

P91 - ACETYLCHOLINE INDUCES CHANGES IN PROTEIN FOLDING REGIMEN AND CYTOSKELETON ORGANIZATION

            Lombardi B, Giorgi A, Mignogna G, Orlando V, Biagioni S, Augusti-Tocco G, Schinine ME*

 

P92 - CHRONIC TREATMENT WITH AMYLOID beta1-42 CHANGES AGONIST BINDING AT M1 AND M3 MUSCARINIC RECEPTORS EXPRESSED IN cho CELLS

            Smyckova H, Jakubik J, Dolezal V

 

P93 - THE GTPase AND THE KINASE DOMAINS OF THE PARKINSON'S DISEASE ASSOCIATED LRRK2: A CLOSE RELATIONSHIP

            Greggio E, Taymans J-M, Beilina A, Vancraenenbroeck R, Baekelandt V, Cookson MR

 

P94 - ROLE OF ATAXIN-3 PHOSPHORYLATION IN SPINOCEREBELLAR ATAXIA TYPE 3 (SCA3) PATHOGENESIS

            Pastori V, Sangalli E, Nonnis S, Tedeschi G, Coccetti P, Fusi P

 

P95 - ANTIBODIES AGAINST NEURONAL NICOTINIC ACETYLCHOLINE RECEPTORS: POTENTIAL ROLE IN NEURODEGENERATION

            Lykhmus OYu, Koval LM, Gergalova GL, Cloez-Tayarani I, Tzartos SJ, Tsetlin VI, Bachinskaya NYu, Skok MV*

 

P96 - GENETIC REPROGRAMMING OF DISEASE-SPECIFIC FIBROBLASTS

            Ungaro F, Loponte S, Laterza C, Di Stefano B and Broccoli V

 

P97 - FUNCTIONAL CONSEQUENCES OF WASH-RESISTANT XANOMELINE BINDING AT M2 AND M4 MUSCARINIC RECEPTORS

            Machova E, Jakubik J, El-Fakahany EE, Dolezal V

 

P98 - INFLUENCE OF ALCURONIUM ON ACTIVATION OF M1-M4 MUSCARINIC RECEPTORS SIGNALLING BY CARBACHOL

            Randakova A, Jakubik J, El-Fakahany EE, Dolezal V

 

P99 - MATHEMATICAL MODELING AND SIMULATION OF NEURO-CHIPS

            Sacco R

 

P100 - INFLUENCE OF MEMBRANE CHOLESTEROL CONTENT ON MUSCARINIC RECEPTOR STIMULATION OF GQ/11 G-PROTEIN SIGNALING

            Michal P, Rudajev V, El-Fakahany EE, Dolezal V

 

P101 - CEREBELLAR IMMUNOLOCALIZATION OF THE GUANINE EXCHANGE FACTOR RASGRF1 AND CHANGES IN THE PROTEOME PROFILE INDUCED BY ITS GENETIC DELETION IN MICE

            Rusconi F*, Colombo G, Fontana E, Bachi A, Vitellaro-Zuccarello L, Zippel R, De Biasi S

 

P102 - 17-(ALLYLAMINO)-17-DEMETHOXYGELDANAMYCIN (17-AAG) A PHARMACOLOGICAL APPROACH TO INDUCE DEGRADATION OF MISFOLDED PROTEINS

            Rusmini P, Crippa V, Simonini F, Bolzoni E, Poletti A

 

P103 - MOLECULAR BIOMARKER/S OF HUNTINGTON'S DISEASE PATHOGENESIS IN HUMAN PERIPHERAL BLOOD AND CLONALLY STRIATA-DERIVED RAT CELLS

            Bregant E, Temil L, Marcuzzi F, Passon N,Siciliano G, Ceravolo R,Unti E, Damante G, and IR Lonigro*

 

P104 - THE ROLE OF REST AND ITS ASSOCIATED COFACTOR BHC80 IN MODULATING NEURONAL FUNCTIONS

            Klajn A, Ferrai C, Stucchi L, Prada I, Meldolesi J, DŐAlessandro R*

 

P105 - WALLERIAN-LIKE DISTAL AXONAL DEGENERATION FOLLOWING LOCAL AXOTOMY IN A NOVEL MICROFLUIDIC CULTURE SYSTEM

            Kilinc D*, Peyrin JM, Saias L, Soubeyre V, Viovy JL, and Brugg B

 

P106 - SOD1 EFFECT ON CELL CYCLE PROGRESSION IN AN ALS MODEL

            Ghiroldi A, Bianchi M, Mazzini G, Guareschi S, Ceroni M, Cereda C*, Cova E

 

P107 - TEMPORAL EVOLUTION OF SPINAL NETWORK ACTIVITY IN WILD TYPE AND G93A MUTANT MOUSE ORGANOTYPIC CULTURES

            Rancic V, Villari A, Ballerini L

 

P108 - PROTEINS RELATED TO NEURODEGENERATION ARE DIFFERENTIALLY EXPRESSED IN FIBROBLASTS FROM FAMILIAL ALZHEIMER'S DISEASE MUTATION CARRIERS, BOTH SYMPTOMATIC AND PRE-SYMPTOMATIC

            Magini A, Ciccarone V, Tancini B, Urbanelli L, Trivelli F, Polidoro M, Sorbi S, Zolla L, Emiliani C*

 

P109 - 9,10-ANTHRAQUINONE INTERFERES WITH Abeta-PEPTIDE AGGREGATION: MECHANISM OF ACTION

            Convertino M*, Pellarin R, Catto M, Carotti A, Caflisch A

 

P110 - ALTERED AXONAL GROWTH OF CULTURED SYMPATHETIC NEURONS FROM DYSTROPHIC MDX MICE

            Lombardi L*, De Stefano ME, Hoogenraad CC, Paggi P

 

P111 - ECTOPIC ATP SYNTHESIS: A NEW CORRELATION BETWEEN MITOCHONDRIAL DISORDERS AND NEURODEGENERATIVE DISEASES

            Ravera S, Calzia D, Bianchini P, Aluigi MG, Diaspro A, Mancardi G, Morelli A, Pepe IM, Panfoli I*

 

P112 - EFFECT OF GABA-A RECEPTOR SIGNALLING MODULATION ON NEURAL PRECURSORS

            Fila T, Ciccolini F

 

P113 - PHENOTYPICAL CHARACTERIZATION OF THIRD TRIMESTER HUMAN AMNIOTIC FLUID CELLS WITH POTENTIAL FOR THERAPY IN NEURODEGENERATIVE DISORDERS

            Cigognini D*, Nicora E, Ripamonti E, Adami R, Abrignani S, Moro M, Rebulla P, Di Giulio AM, Bottai D, Gorio A

 

P114 - MOTONEURON TRANSPLANTATION RESCUE THE PHENOTYPE OF SPINAL MUSCULAR ATROPHY WITH RESPIRATORY DISTRESS TYPE 1 (SMARD1)

            Monica Nizzardo*, Stefania Corti, Martina Nardini, Chiara Donadoni, Sabrina Salani, Dario Ronchi, Roberto Del Bo, Dimitra Papadimitriou, Federica Locatelli, Nereo Bresolin, Giacomo P Comi,

 

P115 - NEURAL STEM CELLS DERIVED FROM GENETICALLY ENGINEERED, LINEAGE-SELECTABLE ES CELLS IMPROVES THE PHENOTYPE OF A MOUSE MODEL OF SPINAL MUSCULAR ATROPHY

            C Simone*, S Corti, M Nizzardo, S Salani, M Nardini, C Donadoni, D Ronchi, M Falcone, N Bresolin, GP Comi,

 

P116 - MATRIX METALLOPROTEINASE-9 INCREASES IN THE STRIATUM AND SUBSTANTIA NIGRA OF A MOUSE MODEL OF PARKINSONISM: AN mRNA EXPRESSION, PROTEIN LEVEL AND IMMUNOLOCALIZATION STUDY        

            Annese V, Barcia C, Ros Bernal F, Paggi P, Herrero MT and De Stefano ME*

 

P117 - AN IN VITRO MODEL OF GLIA ACTIVATION TO DISSECT THE SPECIFIC ROLES OF ASTROCYTES AND MICROGLIA IN NEURODEGENERATIVE DISEASES

            Consonni A, Macco R, Pelizzoni I, Bettegazzi B, Vitali I, Morini M, Rossi FM, Codazzi F, Grohovaz F, Zacchetti D

 

P118 - NERVE GROWTH FACTOR (NGF) RESTORES NEURONAL AND GLIAL FUNCTION IN THE SPARED NERVE INJURY (SNI) MODEL OF NEUROPATHIC PAIN

            Cirillo G, Bianco MR, Colangelo AM*, Cavaliere C, De Luca D, Viggiani S, Fragni M, Alberghina L, Papa M

 

P119 - IS MICROTUBULE DYNAMICS IMBALANCE AN EARLY EVENT IN MPTP-INDUCED NEUROGENERATION?

            Cartelli D*, Molinaro G, Busceti CL, Battaglia G, Giavini E, and Cappelletti G

 

P120 - THE MODULATION OF D-SERINE CONCENTRATION IN THE BRAIN AS A MOLECULAR MECHANISM IN SCHIZOPHRENIA SUSCEPTIBILITY

            Sacchi S*, Cappelletti P, Caldinelli L, Martineau M, Mothet JP, Molla G, Pollegioni L

 

P121 - NEUROMYELITIS OPTICA AUTOANTIBODIES SELECTIVELY RECOGNIZE AQUAPORIN-4 ORTHOGONAL ARRAYS OF PARTICLES

            Pisani F*, Nicchia GP, Mastrototaro M, Rossi A, Tortorella C, Ruggieri M, Lia A, Trojano M, Frigeri A, Svelto M

 

P122 - SOLIDITY OF THE REDUCTION OF THE CHOLESTEROL BIOSYNTHESIS PATHWAY IN HD AND POTENTIAL REGULATORY ROLE OF NORMAL HUNTINGTIN

            Petricca L*, Valenza M, Leoni V, Pouladi MA, Carroll J, Fossale E, Nguyen HP, Riess O, MacDonald M, Hayden M, DiDonato S, Cattaneo E

 

P123 - ROLE OF IGF-1 AUTOCRINE SECRETION AND SIRTUINS REDISTRIBUTION IN THE RESISTANCE OF NEURONAL DIFFERENTIATED CELLS TO STS-INDUCED CELL DEATH

            Tafani M*, Indelicato M, Aventaggiato M, Reali V, Marfe G, Rosa R, Pucci B, Russo MA

 

P124 - FETAL-DERIVED NEURAL STEM (NS) CELLS RETAIN THE IN VIVO POSITIONAL INFORMATION CODE AND DIFFERENTIATE IN APPROPRIATE NEURONAL LINEAGES

            Onorati M*, Conti L, Binetti M, Camnasio S, Calabrese G, Consalez GG, Cattaneo E

 

P125 - A NEW SYSTEMATIC APPROACH TO DETECT BDNF MRNA IN HUMAN BLOOD SAMPLES

            Marullo M, Zuccato C, Di Donato S, Mariotti C, Vandesompele J, Cattaneo E

 

P126 - AN EVOLUTIONARY APPROACH TO THE STUDY OF HUNTINGTIN, THE PROTEIN CAUSING HUNTINGTON'S DISEASE

            Lo Sardo Valentina, Zuccato Chiara, Ramos Catarina, Tartari Marzia, Cattaneo Elena

 

P127 - ASTROCYTES DERIVED FROM NEURAL PRECURSOR CELLS OF WOBBLER MICE INDUCE APOPTOTIC DEATH OF MOTOR NEURONS THROUGH REDUCED GLUTAMATE TRANSPORT

            Diana V, Ottolina A, Botti F, Fumagalli E, Calcagno E, De Paola M, Cagnotto A, Invernici G, Parati E, Curti D, Mennini T

 

P128 - GENERATION OF iPS CELLS FOR MECHANISTICS STUDIES IN HUNTINGTON'S DISEASE

            Christelle Rochon*, Valentina Castiglioni, Alessia Delli Carri, Luciano Conti, Caterina Mariotti, Stefano DiDonato, Marisa Jaconi, Outi Hovatta, Anis Feki, Elena Cattaneo

 

P129 - THE DIVERSITY OF LIFE: AN APPROACH

            Garzn L, Cavero A

 

P130 - GENETIC INTERACTION BETWEEN THE m-AAA PROTEASE ISOENZYME REVEALS NOVEL ROLES IN NEURODEGENERATION

            Martinelli P*, La Mattina V, Bernacchia A, Magnoni R, Cerri F, Cox G, Casari G, Quattrini A, Rugarli EI

 

P131 - SPASTIN:A BRIDGE BETWEEN CYTOSKELETAL REMODELING AND MEMBRANE TRAFFICKING VIA PROTRUDIN-RAB11 PATHWAY

            Martignoni M, Rugarli EI

 

P132 - ROLE OF THE AXONAL-SMN (a-SMN) PROTEIN IN AXON GROWTH AND SPINAL MUSCULAR ATROPHY (SMA) PATHOGENESIS

            Locatelli D*, D'Errico P, Terao M, Capra S, Regano D, Garattini E, Battaglia G.

 

P133 - SELADIN-1 AND BETA-AMYLOID TOXICITY ARE MODULATED BY GnRH.

            Zito A, Cariboni A, Piva F, Maggi R, Galbiati M